Drug composition of oral rehydration salt and preparation method of drug composition

A technology of composition and rehydration salt, which is applied in the field of medicine and can solve unsatisfactory problems

Inactive Publication Date: 2015-01-07
AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventor of the present invention thinks that the new generation of electrolyte balance liquid containing antibiotics, amino acids and other components is not very ideal

Method used

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  • Drug composition of oral rehydration salt and preparation method of drug composition
  • Drug composition of oral rehydration salt and preparation method of drug composition
  • Drug composition of oral rehydration salt and preparation method of drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Effect of the oral rehydration salt composition of the present invention on castor oil-induced diarrhea in mice. 30 mice were randomly divided into 3 groups, respectively: blank group, rehydration salt III group, oral rehydration salt composition group of the present invention, the dosage was 1g / kg, 10 mice in each group, and castor oil 0.1 After 1 ml / 10g, the drug was given by intragastric administration, and then the mice were individually placed in a mouse cage with absorbent paper, and the paper was changed every 1 hour. Diarrhea frequency (loose stool points).

[0035] Table 1: Effect of oral rehydration salt composition of the present invention on castor oil-induced diarrhea in mice

[0036]

[0037] The results show that the oral rehydration salt composition of the present invention can obviously resist castor oil-induced diarrhea in mice.

Embodiment 2

[0039] 1) Prescription (1)

[0040]

[0041] 2) Prescription (1) Preparation process:

[0042] ① Raw material pretreatment:

[0043] Sodium chloride, potassium chloride, sodium citrate, zinc gluconate, protein tannin, anhydrous glucose, and sucralose are crushed through an 80-mesh sieve, carmine pigment is passed through an 80-mesh sieve, strawberry essence is passed through a 60-mesh sieve, Anhydrous glucose is passed through a 40-mesh sieve for later use.

[0044] ②Mix:

[0045] Mix 25g of sucralose with 25g of strawberry essence for 2 minutes to obtain mixture A;

[0046] Mix 1.5 g of carmine and 1.5 g of zinc gluconate for 1 minute, add 3 g of zinc gluconate and mix for 2 minutes, add 6 g of zinc gluconate and mix for 2 minutes, add the remaining zinc gluconate and mix for 2 minutes to obtain mixture B;

[0047] Add mixture A and mix for 2 minutes, add sodium citrate and mix for 2 minutes, then add anhydrous citric acid, potassium chloride, and sodium chloride and m...

Embodiment 3

[0059] 1) Prescription (2)

[0060]

[0061] 2) Prescription (2) Preparation process:

[0062] ① Raw material pretreatment:

[0063]Sodium chloride, potassium chloride, sodium citrate, zinc gluconate, protein tannin, anhydrous glucose, and sucralose are crushed through an 80-mesh sieve, carmine pigment is passed through an 80-mesh sieve, strawberry essence is passed through a 60-mesh sieve, Anhydrous glucose is passed through a 40-mesh sieve for later use.

[0064] ②Mix:

[0065] Mix 25g of sucralose with 25g of strawberry essence for 2 minutes to obtain mixture A;

[0066] Mix 1.5 g of carmine and 1.5 g of zinc gluconate for 1 minute, add 3 g of zinc gluconate and mix for 2 minutes, add 6 g of zinc gluconate and mix for 2 minutes, add the remaining zinc gluconate and mix for 2 minutes to obtain mixture B;

[0067] Add mixture A and mix for 2 minutes, add sodium citrate and mix for 2 minutes, then add anhydrous citric acid, potassium chloride, and sodium chloride and mi...

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Abstract

The invention provides drug composition of oral rehydration salt and a preparation method of the drug composition. The composition comprises main components including sodium chloride, potassium chloride or potassium citrate, sodium citrate, zinc gluconate, albumin tannate and anhydrous glucose. The drug composition of oral rehydration salt can be used for protecting and repairing intestinal mucosa, promoting regeneration of intestinal epithelial cells and reducing secretion of water and electrolyte by the intestinal mucosa, exudation is reduced, and stimulation and intestine peristalsis are relieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition of oral rehydration salt and a preparation method thereof. Background technique [0002] Diarrhea is a common and frequently-occurring disease in children. The main clinical features are: vomiting first followed by diarrhea, accompanied by fever, watery or egg-shaped stools, self-limiting course, and no specific medicine for treatment. If the diarrhea is very severe and the fluid replacement is not timely, dehydration, electrolyte imbalance, and nutrient absorption disorder are prone to occur, which can lead to malnutrition, growth and development disorders, and even death in the long run. [0003] Oral rehydration salts are the drugs recommended by the World Health Organization for the treatment of acute diarrhea and dehydration. The prescription of these drugs is reasonable, cheap and easy to obtain, convenient and efficient, and the sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00A61P3/12A61P1/12A61K33/14A61K31/7004A61K31/7135
Inventor 许馨文
Owner AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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