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Medical stainless steel material and preparation method thereof

A technology of stainless steel and adhesion layer, which is applied in the field of surface modification of biomedical materials, can solve the problems of not being able to provide fixation and growth of osteoblasts, and achieve the effects of being conducive to fixation and growth, improving anti-bacterial adhesion ability, and preventing detachment

Active Publication Date: 2015-01-07
东营慧达科技创业服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But neither of these methods provided fixation and growth of osteoblasts on the surface of the material

Method used

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  • Medical stainless steel material and preparation method thereof

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preparation example Construction

[0041] A kind of preparation method of medical stainless steel material, wherein, described comprises the following steps:

[0042] Step 1. Pretreatment: The surface of the stainless steel sheet is sequentially polished with silicon carbide sandpaper No. 400 to No. 1000, then ultrasonicated with acetone, ethanol and distilled water for 30 minutes, vacuum-dried at 80°C, and then the titanium sheet is soaked in a 5% volume fraction of 3-(Methacryloyloxy)propyltrimethoxysilane ethanol solution, soaked for 1 hour, washed with distilled water, and dried to obtain product 1;

[0043] Step 2, molecular imprinting method combined with surface-initiated atom transfer radical polymerization method for surface modification: 2-(2-methoxyethoxy) ethyl methacrylate and ethylene glycol dimethacrylate were added to water and In ethanol, stir evenly, add osteoblasts, stir evenly; adding area is 1×1cm 2For product 1, add CuBr and methyl α-bromophenylacetate, and react at 100°C for 30 minutes u...

Embodiment 1

[0051] 1. Product preparation

[0052] The surface of the stainless steel sheet was sequentially polished with silicon carbide sandpaper No. 400 to No. 1000, then ultrasonically used for 30 minutes with acetone, ethanol and distilled water, dried in vacuum at 80°C, and then the titanium sheet was soaked in 5% 3-(methacrylic acid) Acyloxy)propyltrimethoxysilane ethanol solution, soaked for 1 hour, washed with distilled water, and dried to obtain product 1; 1.8mol 2-(2-methoxyethoxy)ethyl methacrylate, 0.3 mol of ethylene glycol dimethacrylate was added to 50ml of water and 15ml of ethanol, stirred evenly, and the density was 2×10 after adding 1mL 4 / ml of osteoblasts, stir evenly; adding area is 1×1cm 2 For product 1, add 0.05mol CuBr, 0.01mol α-bromophenylacetic acid methyl ester, and react at 100°C for 30 minutes under the protection of nitrogen to obtain product 2; add product 2 to the aqueous solution of silver nanoparticles, soak for 30-60 minutes, and wash with distilled...

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Abstract

The invention discloses a medical stainless steel material and a preparation method thereof. The medical stainless steel material has the functions of bacterial adhesion resistance, sterilization and promotion of osteoblast growth and comprises a medical stainless steel matrix, a first adhesive layer and a second adhesive layer, wherein the first adhesive layer is a 3-(trifluoromethyl)benzyl mercaptan adhesive layer; the second adhesive layer is a polyethylene glycol compound adhesive layer; the surface of the second adhesive layer adsorbs silver nanoparticles. The medical stainless steel material disclosed by the invention can improve the adhesive capability of the polyethylene glycol compound on the surface of the stainless steel to prevent falling off; furthermore, the polyethylene glycol compound is utilized to improve the bacterial adhesion resistance of the stainless steel, so as to avoid that the bacteria are adhered and proliferate on the surface of the stainless steel; in addition, the silver nanoparticles are utilized to improve the bactericidal ability of the stainless steel. According to the invention, a molecular imprinting method is utilized during the process that the polyethylene glycol compound adhesive layer is introduced, so as to enable the stainless steel material to achieve a function of effectively identifying the osteoblast molecules and help the osteoblast to be fixed and grow on the surface of the material.

Description

technical field [0001] The invention relates to the field of surface modification of biomedical materials, in particular to a medical stainless steel material and a preparation method thereof. technical background [0002] Medical stainless steel has high hardness, moderate weight, cheap price, and is easy to make. However, stainless steel itself has no antibacterial and sterilizing capabilities, so when medical stainless steel is used for dental implants and bone implants, infection is easy to occur, and it will endanger human life in severe cases. Therefore, it is necessary to improve the antibacterial performance and bactericidal ability of stainless steel. [0003] The growth of bacteria on the surface of materials can be divided into three steps: first, the adhesion of bacteria on the surface of materials, then the reproduction of bacteria, and finally the formation of a stable biofilm. Therefore, materials with anti-bacterial adhesion function and bactericidal ability...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/28A61L27/04A61L27/54A61L27/50A61L27/56C23C22/02
Inventor 李培源苏炜霍丽妮陈睿
Owner 东营慧达科技创业服务有限公司
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