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High-strength antimicrobial nanometer composite cation double-network hydrogel and preparation method thereof

A nano-composite, hydrogel technology, applied in the fields of botanical equipment and methods, chemicals for biological control, biocides, etc. The effect of improving mechanical properties

Active Publication Date: 2015-01-07
广州慈康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical properties of this type of gel have not been able to meet the ideal standard for use.

Method used

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  • High-strength antimicrobial nanometer composite cation double-network hydrogel and preparation method thereof
  • High-strength antimicrobial nanometer composite cation double-network hydrogel and preparation method thereof
  • High-strength antimicrobial nanometer composite cation double-network hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Weigh 2.7934g (0.01mol) of (3-acrylamidopropyl) trimethyl quaternary ammonium salt, 0.0617g (5×10 -4 mol), 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure2959) 0.0112g (5×10 -5 mol), add 10ml of deionized water, mix evenly, pour the solution into the self-made silicone rubber template, 400W ultraviolet light is cross-linked for 1 hour, and the first network hydrogel is obtained;

[0031] Then weigh 14.216g (0.2mol) of acrylamide, 0.015g (1×10 -4 mol), initiator potassium persulfate 0.054g (2×10 -4 mol), add 100ml deionized water, dissolve evenly, put the first network into the solution, fully swell, react at 60°C for 10 hours, and obtain high-strength antibacterial cationic double network hydrogel; according to QB / T2591-2003 Standard, carry out bacteriostasis test of Gram-positive bacteria-Staphylococcus aureus and negative bacteria-Escherichia coli to the sample, the results are as follows: figure 1 , 2 and shown in Table 1.

[0032] As can be seen f...

Embodiment 2

[0035] Weigh 0.0103 g of nano-montmorillonite, add 10 ml of deionized water, ultrasonicate for 1 h, and then mechanically stir for 24 h. Then weigh (3-acrylamidopropyl) trimethyl quaternary ammonium salt 2.7934g (0.01mol), crosslinking agent N,N'-methylenebisacrylamide 0.0617g (5 × 10 -4mol), 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure2959) 0.0112g (5×10 -5 mol), after mixing evenly, the solution was poured into a self-made silicone rubber template, and 400W ultraviolet light was crosslinked for 1 hour to obtain the first network hydrogel;

[0036] Then weigh 14.216g (0.2mol) of acrylamide, 0.015g (1×10 -4 mol), initiator potassium persulfate 0.054g (2×10 -4 mol), add 100ml deionized water, dissolve evenly, put the first network into the solution, fully swell, and react at 60°C for 10 hours to obtain a high-strength antibacterial nanocomposite cationic double network hydrogel.

[0037] The gained hydrogel is cut into long 50mm with a cutting knife, wide 10...

Embodiment 3

[0039] The preparation method is the same as in Example 2, except that the dosage of nano-montmorillonite is 0.0206 g; the test results of the mechanical properties of the prepared hydrogel are listed in Table 2.

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Abstract

The invention discloses a high-strength antimicrobial nanometer composite cation double-network hydrogel and a preparation method thereof. The hydrogel comprises a first network hydrogel and a second network hydrogel. The preparation method comprises the steps of dissolving a quaternary ammonium monomer, a crosslinking agent and an initiator for the first network hydrogel in an aqueous dispersion containing nanometer montmorillonite, uniformly mixing, and curing and crosslinking under ultraviolet light to obtain the first network hydrogel; dissolving a polymerizable monomer, a crosslinking agent and an initiator in water and then adding the first network hydrogel, fully swelling and reacting to obtain the high-strength antimicrobial nanometer composite cation double-network hydrogel. The preparation method disclosed by the invention has the advantages of simple process and high reaction speed and the hydrogel has excellent mechanical properties and also has antibacterial effect; the material is expected to be widely used in fields such as chemical industry, agriculture and bio-medicines.

Description

technical field [0001] The invention relates to the technical field of nanocomposite hydrogel preparation, in particular to a high-strength cationic double network hydrogel with antibacterial effect composed of inorganic nanoparticles-montmorillonite and hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a gel with water as the dispersion medium. It is a polymer network system. It is soft in nature and can absorb a large amount of water, but it is insoluble in water and can maintain a certain shape. It can maintain a certain shape in water. A certain amount of external force will restore it to its original state. The hydrogel has good permeability to low molecular substances, has excellent biocompatibility, and has drug sustained release performance. Therefore, hydrogels can be developed not only as sensors, artificial muscles, enzymes, cell immobilization and memory materials, but also as drug carriers, tissue engineering matrix materials ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/26C08L33/24C08J3/075C08F220/60C08F222/38C08F220/56C08F2/44C08K3/34A01N37/20A01P1/00
Inventor 东为富李婷陈明清马丕明
Owner 广州慈康生物科技有限公司
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