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Pharmaceutical composition used for protecting liver and preparation method thereof

A composition and drug technology, applied in the directions of drug combination, drug formulation, drug delivery, etc., can solve the problems of disappointment in curative effect, obvious adverse reactions, deterioration, etc.

Active Publication Date: 2015-01-14
广东南方医大科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, interferon is commonly used clinically to treat chronic hepatitis B. Although it is widely used, the curative effect is more and more disappointing. At the same time, interferon has indications and obvious adverse reactions in the treatment of hepatitis B, which is inconsistent with the characteristics of liver diseases in my country; another The commonly used drug lamivudine is favored by doctors and patients in the early stage of its application because of its rapid virus suppression, high hepatitis B virus DNA conversion rate, mild and less adverse reactions, and relatively low price. Prolonged, problems gradually emerged; such as inducing the mutation of hepatitis B virus, the reality of being happy before worrying, narrow indications, limited therapeutic effect, long-term treatment course, "rebound" after drug withdrawal, and may make the disease worse. Significantly worsened, or even worsened
[0004] my country is a country with a high incidence of hepatitis, and there are more than 200 million patients with various types of liver diseases. Most of them need drugs with liver protection effects. The research on liver injury in modern medicine is relatively in-depth. The mechanism of liver injury has been discussed from many aspects, and the development of A variety of liver-protecting drugs have been developed, but the curative effect is still unsatisfactory; Chinese medicine has the characteristics of multi-target and multi-link comprehensive effects, and has unique advantages in the treatment of liver injury

Method used

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Experimental program
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Effect test

Embodiment Construction

[0011] Preparation of pharmaceutical preparations: take 20 kg of Ligustrum lucidum, 10 kg of Schisandra, 13 kg of Epimedium, 25 kg of Polygonum cuspidatum, 13 kg of Ziheche, 15 kg of Acanthopanax, 13 kg of Astragalus, 15 kg of paeonol, and 15 kg of Radix Isatidis , Scutellaria baicalensis 11 kg, Sangji 11 kg, Bupleurum 10 kg. According to the following process, the four traditional Chinese medicines of Ligustrum lucidum, Schisandra, Polygonum cuspidatum, and Scutellaria baicalensis are mixed and extracted twice with ethanol, each time adding 6 times the amount of 70% ethanol for reflux extraction for 1 hour, and obtaining extract A after recovering ethanol; Acanthopanax, Radix Astragali, Banlangen, Sangji, Bupleurum, and Ziheche 7 traditional Chinese medicines were extracted twice by decocting, adding 10 times of water each time to extract twice, and the extract was concentrated into an infusion with a relative density of about 1.20. After the paste, add ethanol until the alco...

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PUM

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Abstract

The invention relates to a pharmaceutical composition used for protecting liver. The pharmaceutical composition comprises active ingredients and pharmaceutically acceptable auxiliary materials. The pharmaceutical composition is characterized in that the active ingredients are prepared from the following raw medicinal materials in parts by weight: 1.5-2.5 parts of glossy privet fruit, 0.5-1.5 parts of schisandra chinensis, 1-1.5 parts of herba epimedii, 2-3 parts of polygonum cuspidatum, 1-1.5 parts of human placenta, 1-2 parts of manyprickle acanthopanax root, 1-1.5 parts of astragalus, 1-2 parts of cortex moutan, 1-2 parts of isatis root, 0.5-1.5 parts of scutellaria baicalensis, 0.5-1.5 parts of herba taxilli and 0.5-1.5 parts of radix bupleuri. The pharmaceutical composition used for protecting liver has the functions of nourishing liver and kidney, clearing away heat and toxic materials and regulating qi and blood; meanwhile the pharmaceutical composition has an inhibiting effect on hepatitis B virus and can be used for reducing aminotransferase and enhancing body immunologic function; the pharmaceutical composition has extremely small toxic and side effects and obvious treatment effect, and an ideal medicine is provided for a patient suffering from liver damage.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a Chinese patent medicine prepared from traditional Chinese medicines. Background technique [0002] Chronic hepatitis B is a common and frequently-occurring disease in my country, which endangers the health of people of all ages. During liver disease, liver function is damaged to varying degrees, liver detoxification, excretion function, reserve and regeneration ability are reduced, liver blood flow is reduced, and various enter Drugs in the liver aggravate the metabolic load, resulting in internal environment disturbance, which in turn causes liver damage. Long-term liver damage can lead to liver cirrhosis and even liver cancer. [0003] At present, interferon is commonly used clinically to treat chronic hepatitis B. Although it is widely used, the curative effect is more and more disappointing. At the same time, interferon has indications and obvious adverse reactions in the treatment o...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/71A61P1/16
CPCA61K9/0053A61K9/2059A61K9/4866A61K35/50A61K36/185A61K36/195A61K36/233A61K36/254A61K36/296A61K36/315A61K36/481A61K36/539A61K36/57A61K36/638A61K36/704A61K36/71A61K36/79A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 魏凤环沈群贺松其陈达理
Owner 广东南方医大科技开发有限公司