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American ginseng conversion saponin, traditional Chinese medicine mouth care composition thereof and preparation method and application

A technology for converting saponins and oral care, applied in the field of oral hygiene products, can solve the problems of human body and environmental hazards, safety and environmental pollution, unstable product output, etc., and achieve the effect of obvious effect and difficult recurrence.

Inactive Publication Date: 2015-02-04
任贵兴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, high-temperature acid treatment or alkaline treatment requires the application of acid and alkali, which itself has problems such as safety and environmental pollution; although microbial degradation treatment and enzyme treatment have mild conditions, the product output is unstable; chemical chromatography often uses organic solvents , more harmful to the human body and the environment to be eliminated

Method used

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  • American ginseng conversion saponin, traditional Chinese medicine mouth care composition thereof and preparation method and application
  • American ginseng conversion saponin, traditional Chinese medicine mouth care composition thereof and preparation method and application
  • American ginseng conversion saponin, traditional Chinese medicine mouth care composition thereof and preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] likefigure 1 The reaction formula of American ginseng transformed saponin shown, the preparation method of described American ginseng transformed saponin:

[0036] (1) Weigh 150g of American ginseng leaf crude saponin and add 1000ml of water to dissolve it, add 1g of catalyst A, and heat it in an autoclave for 2 hours at a temperature of 120°C;

[0037] (2) Rotary evaporation temperature is 50°C, vacuum degree is 0.02MPa, and the converted product is concentrated to 200ml;

[0038] (3) Purification and enrichment by AB-8 macroporous resin, eluting with water, 30%, 60%, 80%, 95% ethanol water, and the elution volume is 1 column volume;

[0039] (4) Collect 60% and 80% ethanol eluted components, remove the solvent to obtain 60% and 80% ethanol water eluted solid component powders.

[0040] (5) American ginseng transformed saponins obtained through technological treatment: the contents of rare saponins such as Rg2 25%, Rg3 20.1%, Rg6 36%, Rh4(S) 4.1%, C-k3.0% are greatly ...

Embodiment 2

[0042] The preparation method of American ginseng transformation saponin:

[0043] (1) Weigh 250g of American ginseng leaf crude saponin and add 2000ml of water to dissolve it, add 4g of catalyst A, and heat it in an autoclave for 5 hours at a temperature of 140°C;

[0044] (2) Rotary steaming temperature is 80°C, vacuum degree is 0.1MPa, and the converted product is concentrated to 600ml;

[0045] (3) Purify and enrich by AB-8 macroporous resin, elute with water, 30%, 60%, 80%, 95% ethanol water, and the elution volume is 5 column volumes;

[0046] (4) Collect 60% and 80% ethanol eluted components, remove the solvent to obtain 60% and 80% ethanol water eluted solid component powders.

[0047] (5) American ginseng transformed saponins obtained through technological treatment: the contents of rare saponins such as Rg2 25%, Rg3 20.1%, Rg6 36%, Rh4(S) 4.1%, C-k3.0% are greatly improved, and the transformed Rare ginsenoside content is above 95%.

Embodiment 3

[0049] The preparation method of American ginseng transformation saponin:

[0050] (1) Weigh 200g of American ginseng leaf crude saponins and add 1400ml of water to dissolve, add 2g of catalyst A, and heat-treat in an autoclave for 3 hours at a temperature of 140°C;

[0051] (2) Rotary evaporation temperature is 65°C, vacuum degree is 0.06MPa, and the converted product is concentrated to 400ml;

[0052] (3) Purification and enrichment by AB-8 macroporous resin, eluting with water, 30%, 60%, 80%, 95% ethanol water, and the elution volume is 3 column volumes;

[0053] (4) Collect 60% and 80% ethanol eluted components, remove the solvent to obtain 60% and 80% ethanol water eluted solid component powders.

[0054] (5) American ginseng transformed saponins obtained through technological treatment: the contents of rare saponins such as Rg2 25%, Rg3 20.1%, Rg6 36%, Rh4(S) 4.1%, C-k3.0% are greatly improved, and the transformed Rare ginsenoside content is above 95%.

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Abstract

The invention discloses an American ginseng conversion saponin, a traditional Chinese medicine mouth care composition thereof and a preparation method and application, relating to the field of oral hygiene products. The method for preparing the American ginseng conversion saponin mainly comprises the following steps: dissolving in water, performing high temperature treatment, performing rotary evaporation, performing macroporous resin purification and enrichment and eluting. The traditional Chinese medicine mouth care composition comprises the following components in parts by weight: 0.5-50 parts of American ginseng conversion saponin and 50-99.5 parts of conventional pharmaceutical adjuvants or nursing auxiliary materials. The American ginseng conversion saponin has good effects of inhibiting and killing bacteria, deodorizing and preventing tooth decay. The mouth care product fundamentally kills oral pathogenic germs, has obvious curative effects on oral problems such as ozostomia, decayed tooth and dental ulcer caused by bacteria and is a pure traditional Chinese medicine mouth care product which is safe and does not have any toxic or side effect.

Description

technical field [0001] The invention relates to the field of oral hygiene products, in particular to American ginseng converted saponins, a traditional Chinese medicine oral care composition and a preparation method and application thereof. Background technique [0002] The common oral diseases of mankind have dental caries, periodontitis and bad breath, and wherein bad breath is the most unbearable of people. At present, it is believed that the main cause of oral diseases, including oral ulcers and bad breath, is caused by the normal flora in the oral cavity under the condition of oral dysbiosis, which belongs to endogenous infectious diseases. Among them, Candida albicans (ATCC10231) is the primary culprit that causes oral thrush; Porphyromonas gingivalis (ATCC33277), Fusobacterium nucleatum (ATCC10953), etc. are the main causes of dental plaque, and the bacteria in dental plaque Toxins and other harmful substances produced by bacteria can cause host inflammation, increas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K8/97A61Q11/00A61P1/02
CPCA61K36/258A61K8/97A61Q11/00
Inventor 任贵兴薛鹏么杨杨修仕
Owner 任贵兴
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