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Preparation method of pH-sensitive coaxial drug-loading nanometer fiber membrane

A nano-drug-loading and sensitive technology is applied in the directions of pharmaceutical formulations, fiber processing, and medical preparations with inactive ingredients, which can solve the problem of high cost and achieve the effects of low cost, good application prospects and simple process.

Inactive Publication Date: 2015-02-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pH-sensitive materials used mainly include polyacrylic acid, an enteric coating agent, but the cost is relatively high

Method used

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  • Preparation method of pH-sensitive coaxial drug-loading nanometer fiber membrane
  • Preparation method of pH-sensitive coaxial drug-loading nanometer fiber membrane
  • Preparation method of pH-sensitive coaxial drug-loading nanometer fiber membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 3g of shellac, dissolve it in 5ml of ethanol solution, rotate and shake at a speed of 200rpm on a shaker at 40°C for 4 hours, and obtain a brown transparent solution as the shell solution; weigh 1g of PVA, and dissolve it In 10ml of water, stirred in a water bath at 65°C for 1 hour to obtain a transparent solution. After cooling, add 0.1 g of omeprazole, and rotate and shake at a speed of 100 rpm on a shaker at 37°C for 0.5 hours to obtain a core layer solution.

[0028] Put the prepared two spinning solutions into 5mL syringes respectively, use the coaxial spinning head as the injection tube, connect the negative electrode of the high-voltage power supply, connect the aluminum foil fiber receiving plate to the positive electrode, and adjust the syringe pump to control the amount of solution ejection. Adjust the advancing speed of the shell layer solution to 2ml / h, adjust the advancing speed of the core layer solution to 1ml / h, adjust the receiving distance to 15c...

Embodiment 2

[0030] Weigh 3g shellac, dissolve it in 5ml ethanol solution, rotate and shake at a speed of 200rpm on a shaker at 40°C for 4 hours to obtain a brown transparent shell solution; weigh another 1g PVA, dissolve it in 10ml In water, stir in a water bath at 65°C for 1 hour, take out the transparent solution, and after cooling, add 0.1 g of aspirin, rotate and shake at a speed of 100 rpm on a shaker at 37°C for 0.5 hour to obtain a core layer solution.

[0031] Add the prepared two spinning solutions into 5mL syringes respectively, use the coaxial spinning head as the injection tube, connect the negative electrode of the high-voltage power supply, connect the aluminum foil fiber receiving plate to the positive electrode, and adjust the syringe pump to control the amount of solution ejection. Adjust the advancing speed of the shell solution to 3ml / h, adjust the advancing speed of the core solution to 1.5ml / h, and adjust the receiving distance to 15cm. Then start the high voltage pow...

Embodiment 3

[0033] Weigh 3g shellac, dissolve it in 5ml ethanol solution, rotate and shake at a speed of 200rpm on a shaker at 40°C for 4 hours to obtain a brown transparent shell solution; weigh another 1g PVP, dissolve it in 10ml ethanol , stirred in a 65°C water bath for 1 hour. The transparent solution was taken out, after cooling, 0.1 g of ketoprofen was added, and the solution was rotated and shaken at 100 rpm on a shaker at 37° C. for 0.5 hours to obtain a core layer solution.

[0034] Inject the prepared two spinning solutions into 5mL syringes respectively, use the coaxial spinning head as the injection tube, connect the negative electrode of the high-voltage power supply, connect the aluminum foil fiber receiving plate to the positive electrode, and adjust the syringe pump to control the spray volume of the solution. Adjust the advancing speed of the shell solution to 2ml / h, adjust the advancing speed of the core solution to 1ml / h, adjust the receiving distance to 15cm, then sta...

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Abstract

The invention relates to a preparation method of a pH-sensitive coaxial drug-loading nanometer fiber membrane. The method comprises the following steps: dissolving a high polymer material with pH-sensitivity into ethanol to obtain a transparent and clear high polymer solution serving as a shell material; and in addition, dissolving a medicine and a high polymer material into ethanol or a water solution, and mixing evenly to obtain a core liquid; and pouring the obtained spinning solution into an injection propeller, and spinning by using a coaxial electrostatic spinning method to obtain the drug-loading nanometer fiber membrane. The method is simple in process, and low in cost; a pH-sensitive material is applied to a shell layer in coaxial fibers; and the material with good drug compatibility is applied to a drug-loading core layer, so that the drug burst effect can be effectively avoided; and the prepared nanometer fiber membrane can achieve pH-response drug release, and has a relatively good application prospect in targeted drug delivery of gastrointestinal tracts.

Description

technical field [0001] The invention belongs to the field of preparation of medicinal materials, in particular to a preparation method of a pH-sensitive coaxial drug-loaded nanofiber membrane. Background technique [0002] Oral administration is a common way of administration. Different from other drug delivery methods, oral drug delivery is the preferred drug delivery route for disease treatment because of its good safety and good human compliance. In addition to common tablets and capsules, oral preparations also include a series of preparation forms such as suspensions, powders, sustained-release osmotic pumps, and dropping pills. These preparations solve the problems of absorption and sustained release of drugs after they are taken orally into the human body to varying degrees, and have achieved good curative effects. For example, through powder granules and suspensions, traditional Chinese medicine decoctions can be converted into convenient granules, and some insolub...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/34A61K47/32A61K31/4439A61K31/616A61K31/192D01D5/00
Inventor 何创龙聂伟仇可新冯炜
Owner DONGHUA UNIV
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