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Pharmaceutical composition for treating duodenal ulcer

A duodenal ulcer and composition technology, applied in the field of traditional Chinese medicine, can solve the problems of increased plasma gastrin, toxic and side effects, easy recurrence, etc., achieve the effect of alleviating abdominal pain, low production cost, and good ulcer healing effect

Inactive Publication Date: 2015-03-04
青岛申达高新技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these western medicines are effective in treating the disease, they are expensive, easy to relapse, and have certain toxic and side effects. It has been confirmed that long-term use of omeprazole can cause a feedback reversible increase in plasma gastrin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 Chinese medicine granules

[0015] Weigh 1.30kg of pumpkin silk, 1.0kg of white leaves, 1.10kg of bellflower, 1.75kg of chestnut shell, 1.75kg of cucumber vine, 0.75kg of Sichuan Phellodendron, 1.05kg of glutinous rice root, 0.40kg of rose, 0.3kg of impatiens and vine vine 0.75kg, combined, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal material, decoct for 2 hours, add water for the second time to 8 times the weight of the medicinal material, decoct for 1.5h, combine the decoction, 0.08 MPa, 70°C, concentrated under reduced pressure to 70°C, the relative density is about 1.15, add 95% (v / v) ethanol to make the alcohol content reach 75% (v / v), stir, stand overnight, filter, and the filtrate is in Concentrate under reduced pressure at 0.08MPa and 65°C to obtain an extract with a relative density of about 1.15 at 65°C, place the extract in a stainless steel pan, dry it in vacuum (below 60°C) ...

Embodiment 2

[0016] The preparation of embodiment 2 Chinese medicine oral liquid

[0017] Weigh 0.30kg of pumpkin silk, 0.20kg of white leaves, 0.20kg of platycodon, 0.40kg of chestnut shell, 0.30kg of cucumber vine, 0.20kg of Sichuan Phellodendron, 0.15kg of glutinous rice root, 0.06kg of rose, 0.06kg of impatiens and vine 0.11kg, combined, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 2 hours, add water for the second time to 8 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoction, 0.08 MPa, 70 DEG C, concentrated under reduced pressure to 70 DEG C, the relative density is about 1.15, add 95% (v / v) ethanol to make the alcohol content reach 80% (v / v), stir, stand overnight, filter, the filtrate is in Concentrate under reduced pressure at 0.08MPa and 65°C to a relative density of about 1.15 at 65°C, add water and sucrose to prepare oral liquid.

Embodiment 3

[0018] The preparation of embodiment 3 Chinese medicine oral liquid

[0019] Weigh 1.5kg of pumpkin silk, 1.0kg of white leaves, 1.0kg of bellflower, 2.0kg of chestnut shell, 1.5kg of cucumber vine, 1.0kg of Sichuan Phellodendron, 0.75kg of glutinous rice root, 0.3kg of rose, 0.3kg of impatiens and vine vine 0.55kg, combined, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal material, decoct for 2 hours, add water for the second time to 8 times the weight of the medicinal material, decoct for 1.5h, combine the decoction, 0.08 MPa, 70 DEG C, concentrated under reduced pressure to 70 DEG C, the relative density is about 1.18, add 95% (v / v) ethanol to make the alcohol content reach 78% (v / v), stir, stand overnight, filter, the filtrate is in Concentrate under reduced pressure at 0.08MPa and 65°C to a relative density of about 1.15 at 65°C, add water and sucrose to prepare oral liquid.

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Abstract

The invention discloses a pharmaceutical composition for treating duodenal ulcer. The pharmaceutical composition is prepared from the following Chinese herbal medicine raw materials and pharmaceutically acceptable auxiliary materials, wherein the Chinese herbal medicine raw materials comprise the following raw materials in parts by weight: 22-30 parts of cushaw tendril, 18-23 parts of shiny cinquefoil root, 18-25 parts of platycodon grandiflorum, 30-42 parts of chestnut shell, 30-42 parts of cucumber stem, 11-20 parts of golden cypress, 15-25 parts of glutinosae rice root, 6-10 parts of rose, 4-7 parts of impatiens balsamina and 11-20 parts of fructus viticis. The pharmaceutical composition disclosed by the invention used for promoting the restoration of colonic mucosa and quickly relieving a stomachache (the effect can reach 62.2% during the first week) by improving microcirculation; the healing rate of the duodenal ulcer after treatment of four weeks can reach 86.7%; and the pharmaceutical composition has a relatively good ulcer healing effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating duodenal ulcer and a preparation method thereof. Background technique [0002] Duodenal ulcer is a tissue injury beyond the muscularis mucosa caused by the intestinal mucosa being digested by the digestive juice itself. It is more common in young adults and is mainly diagnosed by gastroscopy. The symptoms are: burning pain, dull pain, distending pain or severe pain in the upper abdomen. In mild cases, there is only dull pain and discomfort when hungry. In severe cases, mild or moderate persistent pain under the xiphoid process, and some even midnight pain. The patient often wakes up with pain. Most patients' pain is rhythmic, and most of the pain lasts for several weeks and gradually relieves, and then reappears after several months. Duodenal ulcer is one of the common and frequently-occurring diseases a...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P1/04A61P1/00A61P29/00
CPCA61K36/42A61K9/0053A61K9/08A61K9/1652A61K36/185A61K36/34A61K36/73A61K36/738A61K36/756A61K36/85A61K36/899A61K2300/00
Inventor 不公告发明人
Owner 青岛申达高新技术开发有限公司
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