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A sea cucumber flower extract for promoting postpartum uterine contraction

A technology of uterine contraction and sea cucumber flower is applied in the directions of echinoderms-derived medical raw materials, drug combination, capsule delivery, etc., and can solve problems such as unreported uterine contraction.

Inactive Publication Date: 2018-10-02
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sea cucumber flowers are mostly discarded as waste during sea cucumber processing. The inventors separated and extracted sea cucumber flowers and found that the extracts have multiple activities. Sea cucumber flower extracts have been reported in the prevention and treatment of ovarian aging (see ZL201310280021.9). Uterine contraction has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1. Preparation of sea cucumber flower extract with effect of promoting postpartum uterine contraction:

[0011] Sea Cucumber Flower (Fresh and Frozen) provided by Dalian Bangchuidao Seafood Co., Ltd.

[0012] (1) An appropriate amount of sea cucumber flower tissue, homogenized;

[0013] (2) Add 1.5 times the volume of distilled water, and ultrasonically assist extraction at 30°C for 25 minutes;

[0014] (3) Stir and extract in a water bath at 30°C for 2h, centrifuge at 4000r / min for 5min, take the supernatant, repeat the above operation for the residue, combine the filtrate, concentrate under reduced pressure to 1 / 3 volume, freeze-dry to obtain the sea cucumber flower extract.

Embodiment 2

[0015] Example 2: Effect of Sea Cucumber Flower Extract on Uterine Contraction in Isolated Mice

[0016] Preparation of isolated mouse uterus: non-pregnant female mice received intraperitoneal injection of estradiol valerate every day 2 days before the experiment to increase the sensitivity of the uterus to the drug; the mice were quickly killed by cervical dislocation, and the uterus was taken out by laparotomy to make a long uterus 1.0cm uterine smooth muscle strip. Put the uterus ligated with silk thread into a 20ml McDonald’s bath, fix one end of the uterus ligated silk thread on the specimen fixing hook in the bath, and connect the other end to the tension transducer to give the uterus a load of 1g. After the uterine contraction is stable, start to record the normal contraction curve. For each group, add 1 drop of motherwort water solution (as a control) and various concentrations of sea cucumber flower extract. After the uterine contraction is stable, use Biolap420E + The...

Embodiment 3

[0019] Example 3: Preparation of sea cucumber flower extract tablets

[0020] prescription:

[0021] Sea Cucumber Flower Extract 100mg

[0022] Lactose 100mg

[0023] Starch 295mg

[0024] Magnesium stearate 5mg

[0025] Total 500mg

[0026] Weigh out the main ingredients, mix the sea cucumber flower extract through 80 mesh sieve powder, lactose, starch, wet granulation, drying, after integration, mixing with magnesium stearate, pressing, and compressing each tablet to 500mg tablet.

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PUM

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Abstract

The invention discloses a sea cucumber flower extractive used for promoting postpartum uterus contraction; the sea cucumber flower extractive is the water-soluble matter extracted from the sea cucumber flower, which is the sea cucumber processing waste. The sea cucumber flower extractive has the function of contracting uterus and is used for treating postpartum hemorrhage and incomplete restoration of uterus after medical abortion operation and induced abortion operation.

Description

Technical field [0001] The present invention relates to a new application of sea cucumber flower extract, which is a marine active substance, in preparing medicine for uterine contraction. Background technique [0002] Sea cucumbers belong to the class of Holothurioidea. Modern research shows that sea cucumbers can improve memory, delay gonadal aging, prevent arteriosclerosis, diabetes, and anti-tumor. The sea cucumber flower is the reproductive system of the sea cucumber. The sea cucumber flower not only contains the same abundant active substances as the sea cucumber body wall, but also contains many precious key nutrients, such as polysaccharides, vanadium, nucleic acid, arginine, etc. In addition, sea cucumber flowers are also rich in visceral pigments that have special effects on the human body, also called gonadal pigments. Sea cucumber flowers are mostly discarded as waste during sea cucumber work. The inventors separated and extracted sea cucumber flowers and found that ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/616A61P15/04
CPCA61K9/205A61K9/4866A61K35/616
Inventor 石振艳刘坤高华张惠芳朱兆明
Owner QINGDAO UNIV
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