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Traditional Chinese medicine for treating or preventing radiographic contrast nephropathy for imaging department and preparation method

A technology of contrast agent nephropathy and traditional Chinese medicine, which is applied in the direction of medical formulas, medical preparations containing active ingredients, and drug combinations. strong effect

Inactive Publication Date: 2015-03-25
康静霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in a group of retrospective multiple myeloma observations after receiving contrast agents, the incidence of CAN was only 0.6% to 1.25%.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0043] When the dosage form of any one of the above-mentioned Chinese medicines is a powder, its preparation method may further comprise the steps:

[0044] In the first step, the raw medicinal materials are mixed in proportion and pulverized into powder;

[0045] In the second step, add the powder obtained in the first step into cold water and soak for 6 to 12 hours, decoct with a slow fire for 3 to 5 hours, filter the decoction to obtain the first filtrate, the quality of the added water It is 4 to 8 times the mass of the powder obtained in the first step;

[0046] In the third step, add the filter residue obtained from the second step of filtration into cold water again, decoct with a slow fire for 2 to 4 hours, and filter to obtain the second filtrate. The quality of the added water is 3 to 5 times the quality of the filter residue obtained in the second step. times;

[0047] In the fourth step, the first filtrate obtained in the second step is mixed with the second filt...

Embodiment 1

[0053] Embodiment 1: Powder

[0054] Take 40 parts of nephronitis grass, 260g of corn silk, 170g of mulberry octopus, 240g of zedoary, 210g of dried rehmannia, 130g of Chuanketong, 290g of yew, 160g of root of Gewang, 230g of awn flower, 320g of stephenia vine, 120g of Buddha nail, sunflower 270g of root, 250g of Shichancao and 190g of fake tea spicy.

[0055] Its preparation method comprises the following steps:

[0056] In the first step, the raw medicinal materials are mixed in proportion and pulverized into powder;

[0057] In the second step, add the powder obtained in the first step to soak in cold water for 10 hours, decoct with a slow fire for 5 hours, filter the decoction to obtain the first filtrate, the quality of the added water is the first step 7 times the mass of the powder obtained;

[0058] In the third step, the filter residue obtained by filtering in the second step is added to cold water again, decocted with a slow fire for 3 hours, and filtered to obtai...

Embodiment 2

[0061] Embodiment 2: Granules

[0062] Take 370g of nephritis grass, 280g of corn silk, 160g of mulberry octopus, 220g of zedoary, 240g of dried rehmannia, 110g of Chuanketong, 270g of yew, 190g of root of gegewang, 210g of awn flower, 330g of stephenia vine, 140g of Buddha nail, and sunflower root 250g, Shichancao 230g and fake tea spicy 180g.

[0063] Its preparation method comprises the following steps:

[0064]Step 1: Mix the raw medicinal materials according to the stated ratio, add ethanol with an alcohol concentration 7 times that of the mixture and 95% ethanol, heat to boiling and reflux for 5 hours, filter, and use the percolation method at a rate of 2ml per minute. Percolation, collecting the percolation liquid, then concentrating under reduced pressure at 0.08Mpa to a paste with a relative density of 1.09 at 60°C, spray drying, the inlet air temperature of the spray dryer is 175°C, and the outlet air temperature is 85°C, and then Pulverized into a particle size of...

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Abstract

The invention provides a traditional Chinese medicine for treating or preventing radiographic contrast nephropathy for imaging department and a preparation method. The traditional Chinese medicine consists of the following medicinal raw materials: obovate ainsliaea, corn stigma, ovum of mantis, curcuma zedoary, dried rehmannia, caulis clematidis armandii, taxad, Indian stringbush root, hypericum uralum, Japanese stephania root, manystem stonecrop leaf, sunflower root, dindygulen peperomia herb and rauwolfia. The traditional Chinese medicine disclosed by the invention has the following beneficial effects: in treating or preventing radiographic contrast nephropathy, the traditional Chinese medicine has the advantages of being strong in pertinency, concrete in curative effect, rapid to take effect, low in toxic and side effect and low in recurrence rate.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine for treating or preventing contrast medium nephropathy and its preparation method in the imaging department. Background technique [0002] With the widespread development of modern imaging techniques, contrast associated nephropathy (CAN) has drawn increasing attention from nephrologists. CAN refers to a sudden decrease in renal function caused by contrast media. Commonly used contrast agents are generally hypertonic, with iodine content as high as 37%. In the body, they are filtered by the glomeruli in their original form and not absorbed by the renal tubules. When dehydrated, the concentration of the drug in the kidney increases, which can cause kidney damage. Acute renal failure occurs. Reports of acute renal failure caused by contrast agents are increasing day by day, and even its incidence...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P13/12A61K35/64
CPCA61K9/146A61K9/1652A61K36/13A61K36/185A61K36/28A61K36/41A61K36/58A61K36/59A61K36/67A61K36/716A61K36/804A61K36/83A61K36/899A61K36/9066A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 康静霞朱明
Owner 康静霞
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