Method for carrying out solvent-out crystallization on allopurinol

A technology of dissolution crystallization and allopurinol, which is applied in the fields of medicine and chemical industry, can solve the problems that the product department is easy to meet the requirements of medicine, low equipment production efficiency, and high organic residue, so as to achieve less solvent residue, good product quality, and increase production Effect
CN104447754AInactive Publication Date: 2015-03-25CHONGQING KANGLE PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING KANGLE PHARMA
Publication Date
2015-03-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for carrying out solvent-out crystallization on allopurinol. The method comprises the following steps: (1) dissolving a crude allopurinol product into a sulfones solvent at the temperature of 98-148 DEG C; (2) adding a solution obtained from the step (1) to an antisolvent for crystallization, and separating to obtain the allopurinol. The finished allopurinol product obtained through the method provided by the invention can achieve the yield as high as 95% or more than 95% and achieve the purity more than 99.88% of the purity achieved through an HPLC normalization method. The method provided by the invention has the advantages of simple process, small occupied equipment size, output increase of equipment with same size, solvent recycling, environmental pollution reduction and suitability for industrialized production.
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Description

technical field

[0001] The invention belongs to the technical fields of medicine and chemical industry, and in particular relates to a method for dissolution and crystallization of allopurinol. Background technique

[0002] Allopurinol is also known as allopurinol, aropurine, allopurinol, cyloryl, hydroxypyrazole pyrimidine, the English name is Allopurinol, and the chemical name is 1H-pyrazolo[3,4-d]pyrimidine-4 -alcohol, the chemical structural formula is as follows:

[0003]

[0004] Allopurinol is a xanthine oxidase inhibitor, suitable for various diseases with primary or secondary serum uric acid increase, such as gout, acute or chronic leukemia, polycythemia vera, multiple myeloma and other malignant Hyperuricemia caused by massive necrosis of tumor cells during chemotherapy or radiotherapy can prevent and treat urate nephropathy, etc., with remarkable curative effect and minimal side effects, so it is widely used clinically.

[0005] The preparation method of the ...

Claims

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