Integron In1069

An integron, EC6335 technology, used in DNA preparation, introduction of foreign genetic material and microorganisms using vectors, etc., can solve problems such as multi-drug resistance, animal husbandry and human health hazards, and achieve the effect of preventing outbreaks and reducing selection pressure.
CN104450765AInactive Publication Date: 2015-03-25王冬国
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
王冬国
Publication Date
2015-03-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an integron In1069 with a sequence as shown in SEQ ID NO.1. The integron is found in a genome of drug-resistant Escherichia coli EC6335. The integron contains a plurality of drug-resistant gene cassettes. Therefore, due to the discovery of the integron disclosed by the invention, a certain guiding effect is provided for clinical medication, some clinically-used antibacterial agents can be favorably reduced, the selective pressure for horizontal transfer of the drug-resistant gene cassettes is reduced, and the outbreak of drug-resistant bacteria is avoided.
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Description

technical field

[0001] The invention belongs to the field of molecular biology technology and drug-resistant bacteria monitoring, and relates to a newly discovered integron In1069 closely related to drug resistance of Escherichia coli. Background technique

[0002] Escherichia coli is a typical Gram-negative bacillus, and colibacillosis caused by it is a common disease. The main prevention and control measures for colibacillosis are the application of vaccines and antibiotics. However, with the widespread, continuous and improper application of antibiotics, the drug resistance spectrum of Escherichia coli continues to expand and the level of drug resistance continues to increase. The phenomenon of drug resistance and multi-drug resistance of E. hazards.

[0003] Integron (integron) is a recombinant expression system that can recognize, capture, integrate or cut extracellular episomal genes or gene fragments through its own encoded integrase, and transform them into functio...

Claims

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