Preparation method of ethionamide tablet

A technology of ethionamide tablets and ethionamide, which is applied in the directions of pharmaceutical formulations, antibacterial drugs, active ingredients of heterocyclic compounds, etc. and other problems, to achieve the effect of quick onset, beneficial to the body's absorption and bioavailability, and avoiding cumbersome processes

Active Publication Date: 2015-04-01
CANSINO BIOLOGICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor compliance of long-term standardized treatment for tuberculosis patients in my country, drug-resistant and multidrug-resistant tuberculosis are prone to occur.

Method used

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  • Preparation method of ethionamide tablet
  • Preparation method of ethionamide tablet
  • Preparation method of ethionamide tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] For every 1,000 ethionamide tablets, weigh the materials according to the following formula:

[0049] Tablet core prescription:

[0050]

[0051] Coating liquid prescription:

[0052] Opadry 8.0g

[0053] 95% ethanol 100mL

[0054] Make about 100mL and add water to dilute to 8% solution

[0055] Preparation Process:

[0056] 1. After pulverizing the ethionicotinamide solid dispersion, pass through a 60-mesh sieve, and pass the microcrystalline cellulose, povidone, and croscarmellose sodium through an 80-mesh sieve for use;

[0057] 2. Weigh the prescription amount of ethionicotinamide solid dispersion and croscarmellose sodium, add them to the V-type mixer and mix for 5 minutes, then add the prescription amount of microcrystalline cellulose and povidone and mix for 5 minutes;

[0058] 3. Add the mixture of step 2 to the dry granulator, adjust the pressure of the hydraulic wheel to 1.8MPa and the speed of 10r / min to press it into a thin strip of 3mm thick, which is crushed into small ...

Embodiment 2

[0064] For every 1000 ethionamide tablets, weigh the materials according to the following formula:

[0065] Tablet core prescription:

[0066]

[0067] Coating liquid prescription:

[0068] Opadry 8.0g

[0069] 95% ethanol 100mL

[0070] Make about 100mL and add water to dilute to 8% solution

[0071] Preparation Process:

[0072] 1. After crushing the ethionicotinamide solid dispersion, pass it through a 60-mesh sieve, and pass the microcrystalline cellulose, Ludipress LCE, and cross-linked polyvinylpyrrolidone through an 80-mesh sieve, respectively, for use;

[0073] 2. Weigh the prescription amount of ethionicotinamide solid dispersion and micronized silica gel, add them to the V-type mixer and mix for 5 minutes, then add the prescription amount of microcrystalline cellulose, Ludipress LCE, and cross-linked polyvinylpyrrolidone and mix for 5 minutes;

[0074] 3. Add the mixture of step 2 to the dry granulator, adjust the pressure of the hydraulic wheel to 1.5MPa and the speed of 12r / min ...

Embodiment 3

[0080] For every 1000 ethionamide tablets, weigh the materials according to the following formula:

[0081] Tablet core prescription:

[0082]

[0083]

[0084] Coating liquid prescription:

[0085] Opadry 8.0g

[0086] 95% ethanol 100mL

[0087] Make about 100mL and add water to dilute to 8% solution

[0088] Preparation Process:

[0089] 1. After crushing the ethionicotinamide solid dispersion, pass it through a 40-mesh sieve, and pass the microcrystalline cellulose, povidone and sodium carboxymethyl starch through a 60-mesh sieve for use;

[0090] 2. Weigh the prescription amount of ethionicotinamide solid dispersion and sodium carboxymethyl starch, add to the V-type mixer and mix for 5 minutes, then add the prescription amount of microcrystalline cellulose and povidone, and mix for 5 minutes; add 1 / 2 The prescription amount of magnesium stearate is mixed for 3 minutes;

[0091] 3. Add the mixture of step 3 to the dry granulator, adjust the pressure of the hydraulic wheel to 1.7MPa and...

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Abstract

The invention provides a preparation method of an ethionamide tablet, which comprises the following steps: preparing a solid dispersion, and preparing the ethionamide tablet by a dry granulation / tabletting process or powder direct tabletting process. The dissolution test on the ethionamide tablet indicates that more than 75% of ethionamide can be dissolved out within 45 minutes, and thus, the ethionamide tablet is beneficial to absorption and bioavailability of the organisms and can enhance the antiphthisic treatment effect.

Description

Technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of ethionamide tablets. Background technique [0002] Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, which can invade many organs. The most common form of pulmonary tuberculosis is lung involvement. It is estimated that 8.6 million people worldwide suffered from tuberculosis in 2012, and 1.3 million people died of tuberculosis (including 320,000 HIV-positive people). The 2013 WHO Global Tuberculosis Report pointed out that tuberculosis is still a major global health problem. [0003] It is worth noting that 90% of tuberculosis patients worldwide are in developing countries. China is one of the 22 countries with the heaviest tuberculosis epidemic burden in the world, and it is also one of the 27 countries in the world where multidrug-resistant tuberculosis is severely endemic. The number of tuberculosis patients is seco...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K31/44A61P31/06
Inventor 毛慧华郝桂桐王月然邱东旭
Owner CANSINO BIOLOGICS INC
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