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Medical hemostatic plugging dressing and preparation method thereof

A technology of chitosan and tilapia, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of hemostasis speed and hemostasis volume cannot meet the requirements of emergency treatment, so as to promote wound healing, and the raw materials are cheap and easy to obtain. , the effect of low cost

Inactive Publication Date: 2015-04-01
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hemostasis speed and hemostasis volume of the current chitosan hemostatic products still cannot meet the requirements of emergency treatment for a large amount of rapid bleeding

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A medical hemostatic occlusive dressing, comprising the following components in parts by weight: 24 parts of chitosan, 4 parts of jellyfish collagen, 16 parts of tilapia scale collagen, 0.1 part of aloin, 5 parts of sodium hyaluronate, nano silver 1 part of inorganic antibacterial agent, 5 parts of starch.

[0021] The preparation method is as follows:

[0022] (1) Mix chitosan, jellyfish collagen and tilapia scale collagen evenly, freeze at -20°C for 48 hours, and then freeze-dry at the same temperature for 24 hours to obtain a chitosan freeze-dried film;

[0023] (2) pressurize the freeze-dried film prepared in step (1) at 40° C. to obtain a chitosan film;

[0024] (3) The chitosan film prepared in step (2) is adhered to the base cloth to obtain a medical hemostatic occlusion dressing.

Embodiment 2

[0026] A medical hemostatic occlusive dressing, comprising the following components in parts by weight: 30 parts of chitosan, 7 parts of jellyfish collagen, 13 parts of tilapia scale collagen, 3 parts of aloin, 4 parts of sodium hyaluronate, nano-oxidized 2 parts of zinc, 8 parts of starch.

[0027] The preparation method is as follows:

[0028] (1) Mix chitosan, jellyfish collagen and tilapia scale collagen evenly, freeze at -50°C for 32 hours, and then freeze-dry at the same temperature for 32 hours to obtain a chitosan freeze-dried film;

[0029] (2) pressurize the freeze-dried film prepared in step (1) at 40° C. to obtain a chitosan film;

[0030] (3) The chitosan film prepared in step (2) is adhered to the base cloth to obtain a medical hemostatic occlusion dressing.

Embodiment 3

[0032] A medical hemostatic occlusive dressing, comprising the following components in parts by weight: 36 parts of chitosan, 10 parts of jellyfish collagen, 10 parts of tilapia scale collagen, 5 parts of aloin, 3 parts of sodium hyaluronate, nano silver 3 parts of inorganic antibacterial agent, 10 parts of starch.

[0033] The preparation method is as follows:

[0034] (1) Mix chitosan, jellyfish collagen and tilapia scale collagen evenly, freeze at -70°C for 26 hours, and then freeze-dry at the same temperature for 26 hours to obtain a chitosan freeze-dried film;

[0035] (2) pressurize the freeze-dried film prepared in step (1) at 50° C. to obtain a chitosan film;

[0036] (3) The chitosan film prepared in step (2) is adhered to the base cloth to obtain a medical hemostatic occlusion dressing.

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Abstract

The invention provides a medical hemostatic plugging dressing and a preparation method thereof. The medical hemostatic plugging dressing is prepared from the following components in parts by weight: 24-46 parts of chitosan, 4-16 parts of jellyfish collagen, 4-16 parts of tilapia scale collagen, 0.1-10 parts of aloin, 1-5 parts of sodium hyaluronate, 1-5 parts of an antibacterial agent and 5-15 parts of an adhesive. The preparation method comprises the following steps: uniformly mixing chitosan, jellyfish collagen and tilapia scale collagen, freezing for 24-48h at the temperature ranging from 20 DEG C below zero to 100 DEG C below zero, and then carrying out freeze-drying for 24-48h at the same temperature to obtain a chitosan freeze-dried membrane; carrying out pressurization treatment on the freeze-dried membrane at the temperature of 40-60 DEG C to obtain a chitosan membrane; and adhering the chitosan membrane to base cloth to obtain the medical hemostatic plugging dressing. The medical hemostatic plugging dressing is high in hemostatic speed and is capable of promoting wound healing; the preparation method has the advantages of simple process, low requirement on equipment and use of low-price and easily available raw materials and can be put into industrial production easily.

Description

technical field [0001] The invention relates to the field of medical dressings, in particular to a medical hemostatic blocking dressing and a preparation method thereof. Background technique [0002] Blood loss is one of the important reasons for the death of the wounded. For the hemorrhage and oozing of a large area of ​​soft tissue injury, severe blood loss can also occur if it is not treated in time. Among military training injuries, soft tissue injuries and muscle injuries accounted for 62.5%, and skin injuries accounted for 37.5%. Traditionally, the first aid methods for massive bleeding are all through physical compression, such as bandages, gauze, rubber strips, etc., with limited effects. [0003] Chitosan is the only cationic polysaccharide in nature. It is hypoallergenic, natural antibacterial, and can stop bleeding quickly, so it is especially suitable for first aid; in addition, chitosan is also biocompatible and can be degraded and absorbed in the body. Promote...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/32A61L15/40A61L15/44A61L15/18
Inventor 李苏杨徐勤霞
Owner SUZHOU BEC BIOLOGICAL TECH
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