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Gegen Qinlian oral liquid and preparation method thereof

A technology of Gegen Qinlian and oral liquid, applied in the preparation of Gegen Qinlian oral liquid, the field of Gegen Qinlian oral liquid, can solve the problems of reducing the content of baicalin, affecting the content, affecting the efficacy and the like, and achieving fast onset and absorption Complete, easy-to-use results

Active Publication Date: 2018-02-16
江西心正药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The paper "Study on the Compatibility of Gegen Qinlian Decoction" (Luo Jiabo et al. Chinese Herbal Medicine, No. 4, 2005, 512-518) pointed out that Pueraria lobata and Coptis chinensis reduce the content of baicalin, Coptis chinensis reduces the content of glycyrrhizic acid, Pueraria baicalensis, Scutellaria baicalensis and licorice make The content of berberine decreases, that is, the different compatibility of the four traditional Chinese medicines of Pueraria baicalensis, Scutellaria baicalensis, Coptis chinensis, and Zhigancao will affect the content of active ingredients such as baicalin, glycyrrhizic acid, and berberine in Gegen Qinlian formula, thereby affecting the efficacy of the medicine

Method used

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  • Gegen Qinlian oral liquid and preparation method thereof
  • Gegen Qinlian oral liquid and preparation method thereof
  • Gegen Qinlian oral liquid and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023] In this example, the Gegen Qinlian oral liquid is prepared from the following raw materials in parts by weight: 50 parts of Pueraria root, 18.75 parts of Scutellaria baicalensis, 18.75 parts of Coptidis rhizome, and 12.5 parts of roasted licorice. Prepared as follows:

[0024] (1) Weigh 500g of kudzu root, 187.5g of Scutellaria baicalensis, 187.5g of Coptis chinensis, and 125g of roasted licorice, add water to decoct twice, 1 hour each time, add 8 times the quality water for the first time, add 6.5 times the quality water for the second time, and combine Decoction, filtered;

[0025] (2) Take the filtrate and concentrate to a relative density of 1.10-1.25g / cm 3 Between (80 ℃), cooled to room temperature (can be natural cooling, also can use cooling circulating water to cool), add ethanol to make the alcohol content reach 40%, add sodium hydroxide to adjust the pH to the range of 7.5-9.0, let stand 24 hours;

[0026] (3) Take the supernatant, add ethanol until the alc...

Embodiment 2

[0031] In this example, the Gegen Qinlian oral liquid is prepared from the following raw materials in parts by weight: 60 parts of Pueraria root, 25 parts of Scutellaria baicalensis, 25 parts of Coptidis rhizoma, and 20 parts of roasted licorice. Weigh 600 g of kudzu root, 250 g of scutellaria baicalensis, 250 g of coptis chinensis, and 200 g of roasted licorice, and prepare 1000 mL of kudzu root qinlian oral liquid. The preparation method is the same as in Example 1.

Embodiment 3

[0033] In this example, the Gegen Qinlian oral liquid is prepared from the following raw materials in parts by weight: 40 parts of Pueraria root, 15 parts of Scutellaria baicalensis, 15 parts of Coptidis rhizoma, and 10 parts of roasted licorice. Weigh 400 g of kudzu root, 150 g of scutellaria baicalensis, 150 g of coptis chinensis, and 100 g of roasted licorice, and prepare 1000 mL of kudzu root qinlian oral liquid. The preparation method is the same as in Example 1.

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Abstract

The invention provides a radix puerariae, astragalus membranaceus and coptis chinensis oral solution which is prepared from the following raw medicines in parts by weight: 40-60 parts of radix puerariae, 15-25 parts of astragalus membranaceus, 15-25 parts of coptis chinensis and 10-20 parts of honey-fried licorice root. A preparation method of the oral solution comprises the following steps: adding water, decocting twice, mixing decoction solutions and filtering; concentrating the filtrate until the density is 1.10g / cm<3> to 1.25g / cm<3>, performing gradient alcohol precipitation until the alcohol contents are respectively 30% to 55% and 60% to 85%; taking the liquid supernatant, adding a preparation amount of stevioside, sodium benzoate, ethylparaben, EDTA-2Na and honey, adding a proper amount of water, regulating the pH to 2.0-5.0 and standing still; adding a proper amount of water into the liquid supernatant, regulating the pH to 5.5-7.0 and standing; taking the liquid supernatant, adding the preparation amount of 0.05%-0.15% sodium pyrosulfite, uniformly mixing, filling and sterilizing. The radix puerariae, astragalus membranaceus and coptis chinensis oral solution disclosed by the invention has the main effects of relieving muscles, clearing away heat and relieving diarrhea and dysentery, and is used for treating the dysentery, body fever, polydipsia and dirty diarrhea.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine oral preparations, in particular to a Gegen Qinlian oral liquid and a preparation method of the Gegen Qinlian oral liquid. Background technique [0002] Gegen Qinlian Decoction was first recorded in Zhang Zhongjing's "Treatise on Febrile Diseases". It is composed of four traditional Chinese medicines. Gegen is the king, Qin, Lian, and Gancao are the assistants. It is a classic prescription of traditional Chinese medicine to solve both the exterior and the interior. Gegen Qinlian Tablets and Gegen Qinlian Oral Liquid are different dosage forms of Gegen Qinlian Decoction, which are also recorded in the Chinese Pharmacopoeia. [0003] The paper "Study on the Compatibility of Gegen Qinlian Decoction" (Luo Jiabo et al. Chinese Herbal Medicine, No. 4, 2005, 512-518) pointed out that Pueraria lobata and Coptis chinensis reduce the content of baicalin, Coptis chinensis reduces the co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61K9/08A61P1/12
CPCA61K9/0053A61K9/0095A61K9/08A61K36/481A61K36/484A61K36/488A61K36/718A61K47/46A61K2236/331A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 周伟祥
Owner 江西心正药业有限责任公司