Softening technology and equipment for polysaccharides lyophilized sponge dressing

Abstract

The invention provides a softening technology for polysaccharides lyophilized sponge dressing. The softening technology comprises the following steps: by adopting an ultrasonic energy transduction oscillator, the stored liquid to be atomized is prepared into fine liquid fogdrops by utilizing the physical action of high-frequency oscillation, the fine liquid fogdrops are released into the connected atomization chamber at certain speed by means of wind power, and a sponge block is placed into fog, fully contacts the fog, and gradually imbibes fog so that softening treatment is realized. The invention further provides softening equipment correspondingly, which comprises a liquid storage cavity and the atomization chamber that are communicated with each other, as well as an ultrasonic atomizer and a clamp, wherein the ultrasonic atomizer is arranged at the bottom of the liquid storage cavity and used for atomizing liquid, and the clamp is arranged in the atomization chamber, and used for clamping the sponge block. The softening technology is adopted for softening lyophilized sponge, so that the sponge dressing which is high in density, small in porosity, large in specific surface area and good in wet-state stability, and has excellent resilience and elasticity can be obtained, the equipment is simple in structure, and the pass percent of the produced finished products is high.

Description

technical field [0001] The invention relates to a softening process and equipment for a polysaccharide freeze-dried sponge dressing, belonging to the technical field of medical sponge production and processing. Background technique [0002] At present, in the field of medical technology, whether it is hemostasis and cleaning operations in surgical operations, or postoperative wound healing or other wound healing care, etc., it is still inseparable from the participation of various medical dressings, and the further development of modern medical technology. Higher requirements are put forward for the physical, chemical or biological performance of medical dressings. [0003] Polysaccharide sponge materials have a series of advantages such as easy-to-obtain raw material sources, good biocompatibility, strong liquid absorption capacity, and convenient molding and processing, which provide the possibility for their application in new high-performance medical dressings. Such pro...

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Problems solved by technology

[0004] However, sponge materials traditionally used for dressings are usually prepared by cross-linking foaming, primary or secondary freeze-drying methods, and polysaccharide sponges obtained by such methods have low density, poor compliance, and lack of elasticity , part of the texture is hard and lacks elasticity, and the resulting problem is that sponges with low density generally have large pore sizes, poor water absorption and water retention, and small specific surface area, which is difficult to be used in medical dressings with special requirements for specific surface area. Fields, such as hemostasis (generally, the higher the specific surface area, the better the hemostatic effect); however, the density of the sponge is higher, the hardness is correspondingly higher, and the compliance is poor, especially in the field of medical dressings, it is difficult to fit the wound skin well, especially some Joint active parts

[0005] The above problems have not been solved, and a medical hemostatic polysaccharide freeze-dried sponge (CN201210545888: a preparation method for a hemostatic sponge used in dressings) appears on the market. The sponge has high density, small pores and large specific surface area. , to solve the problem of small density of dressing sponge, but the resulting sponge is hard, poor in resilience, and poor in compliance. When applied to wound hemostasis, it is prone to breakage, which limits its application range

[0006] In order to prepare a dressing sponge with a large specific surface area and good elasticity, some manufacturers add softening additives to the initial formula of the sponge, and the produced dressing sponge has good compliance, but the biocompatibility of the dressing sponge is affected due to the addition of the softening additive sex, thus limiting its clinical use

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