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External spray resistant to skin itch

A technology of skin itching and spray, which is applied in the field of medicine to achieve simple preparation process, fast transdermal absorption, and remarkable anti-itching effect

Inactive Publication Date: 2015-04-22
李健
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Amoxetine is a structurally new 5-HT / NE dual reuptake inhibitor, which has been developed into an oral pharmaceutical preparation. There is no literature reporting that it has the biological activity of topical pruritus

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Preparation of Amoxetine Spray

[0025] Amoxetine 0.5g

[0026] Benzophenone 2g

[0027] Sodium chloride 0.9g

[0028] Ethanol 15ml

[0029] Sodium Benzoate 0.1g

[0030] Distilled water to 100ml

[0031] Preparation:

[0032] (1) At normal temperature and pressure, weigh 0.5g of amoxetine, dissolve it in 80mL of distilled water, add 0.9g of sodium chloride and 0.1g of sodium benzoate, stir to dissolve, and set aside;

[0033] (2) Weigh 2g of benzophenone, dissolve it in 15ml of ethanol, and set aside;

[0034] (3) Add the solution prepared in step (2) to the solution in step (1), stir to mix evenly, add distilled water dropwise to make up to 100ml, mix well, put in a canned sprayer, seal, and inspect to get the finished product.

Embodiment 2

[0035] Embodiment 2 Preparation of Amoxetine Spray

[0036] Amoxetine 1g

[0037] Benzophenone 5g

[0038] Sodium chloride 0.9g

[0039] Ethanol 38ml

[0040] Sodium Benzoate 0.1g

[0041] Distilled water to 100ml

[0042] Preparation:

[0043] (1) At normal temperature and pressure, weigh 1 g of amoxetine, dissolve it in 55 mL of distilled water, add 0.9 g of sodium chloride and 0.1 g of sodium benzoate, stir to dissolve, and set aside;

[0044] (2) Weigh 5g of benzophenone, dissolve it in 38ml of ethanol, and set aside;

[0045] (3) Add the solution prepared in step (2) to the solution in step (1), stir to mix evenly, add distilled water dropwise to make up to 100ml, mix well, put in a canned sprayer, seal, and inspect to get the finished product.

Embodiment 3

[0056] Example 3 Experimental Research of Amoxetine Spray in Resisting Skin Itching in Mice

[0057] 48 Kunming mice, weighing 20-25g, were randomly divided into the following four groups: normal control group, model control group, high-dose and low-dose amoxetine groups, 12 in each group, half male and half male. All mice were depilated with 8% sodium sulfide on the back of the neck, and the depilatory area was 1.5cm×2cm, and then the corresponding external drug of each group (0.05ml) was sprayed on the fixed part (1.5cm×2cm) of the depilatory area on the back of the mouse. 2cm), the low-dose and high-dose groups of amoxetine sprayed the blank spray prepared according to the prescription process of the above-mentioned embodiment 1 and embodiment 2 respectively; the normal control group and the model control group sprayed the blank spray prepared according to the above-mentioned comparative prescription spray. After 45 minutes, all mice except the normal control group were su...

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PUM

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Abstract

The invention discloses external spray resistant to skin itch. The external spray resistant to skin itch is prepared from the following components in percentage by weight: 0.5-1.0% of ammuxetine, 1-5% of diphenyl ketone, 0.6-1.0% of sodium chloride, 10-32% of ethyl alcohol, 0.05-0.20% of sodium benzoate and the balance of distilled water. The external spray resistant to skin itch can be rapidly percutaneously absorbed, is almost non-irritant to skin, has an obvious curative effect in resistance to skin itch caused by non histamine and is easy to use; meanwhile, a preparation process is simple.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an external spray for anti-itching skin. Background technique [0002] Pruritus is a common unpleasant sensation often accompanied by scratching. It is the main symptom of many systemic diseases and skin diseases, which can seriously affect the physical and mental health of patients and reduce the quality of life. Pruritus can be directly caused by chemical mediators of the skin, or it can be caused by changes in physical factors (such as temperature), which in turn can cause reactions in peripheral nerve fibers or even the central nervous system. The more recognized neurobiological mechanism pathway is that exogenous or endogenous itch-causing factors (local neuropeptides such as substance P, etc.) activate mast cells directly or through cytokines, mast cells degranulate, and release histamine-specific NK1 receptors , TNF-α and other substances, directly or indire...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/381A61P17/04
Inventor 李健
Owner 李健
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