Synthesis method of D-dibenzoyl tartaric acid

A technology of dibenzoyl tartaric acid and dibenzoyl tartaric anhydride is applied in the field of chemical synthesis of chiral resolution reagents, which can solve the problems of low utilization rate of raw materials, inability to recycle, large production pollution, etc., and achieve convenient operation, The effect of low cost, improved product yield and product quality
CN104529779AInactive Publication Date: 2015-04-22濮阳天健生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
濮阳天健生物科技有限公司
Publication Date
2015-04-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a synthesis method of D-dibenzoyl tartaric acid. The synthesis method comprises the following steps: reacting by taking D-tartaric acid and benzoyl chloride as raw materials, taking copper sulfate as a catalyst and taking toluene as a solvent to prepare D-dibenzoyl tartaric acid anhydride, adding an equal amount of water, and performing hydrolysis with toluene to obtain D-dibenzoyl tartaric acid, wherein the solvent, namely toluene, and the water and toluene in the hydrolysis step can be recycled. The method provided by the invention has the advantages of simple process, safety, easiness in operation and high process yield of above 95%; and simultaneously, the cost of the raw materials is relatively low, part of the raw materials can be recycled, the purity of a finished product is relatively high, and the chiral separation performance is excellent.
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Description

technical field

[0001] The invention relates to the technical field of a chemical synthesis method of a chiral resolution reagent, in particular to a synthesis method of D-dibenzoyltartaric acid. Background technique

[0002] D-Dibenzoyltartaric acid is a white crystalline powder. It is widely used as an intermediate of the anthelmintic drug levamisole and chiral resolution of amine compounds. And because of its low price, stable properties, and easy recycling, it has good industrial application value. Its molecular formula is as follows:

[0003]

[0004] The defect of common synthetic method is: 1. raw material has strong irritation, strong corrosiveness, hypertoxicity, is difficult for handling. ② The utilization rate of raw materials is low, they cannot be recycled, and the production pollution is relatively large. ③The process yield is low, about 40%, the product purity is lower, and the production cost is higher. Contents of the invention

[0005] The technic...

Claims

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