Nanometer microcrystalline cellulose reinforcing polylactic acid glycolic acid electrospun membrane, preparation method thereof and application

A polylactic acid glycolic acid electrospinning film, polylactic acid glycolic acid technology, applied in the field of biomedicine, can solve problems such as co-spun film without polylactic acid glycolic acid and cellulose, achieve clean and environmentally friendly preparation process, make up for limitations, Simple preparation method

Inactive Publication Date: 2015-04-22
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is currently no co-spun membrane of PLAG and cellulose

Method used

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  • Nanometer microcrystalline cellulose reinforcing polylactic acid glycolic acid electrospun membrane, preparation method thereof and application
  • Nanometer microcrystalline cellulose reinforcing polylactic acid glycolic acid electrospun membrane, preparation method thereof and application
  • Nanometer microcrystalline cellulose reinforcing polylactic acid glycolic acid electrospun membrane, preparation method thereof and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0043] (1) Preparation of nanocrystalline cellulose

[0044] Weigh 15g of microcrystalline cellulose powder, add it to 140mL of 65wt% concentrated sulfuric acid, and mechanically stir it in a water bath at 40°C for 6 hours. Ultrasonic dispersion, followed by repeated dialysis with water three times until the pH value is stable, the dialyzed sample was placed in a refrigerator at 4°C overnight, and then freeze-dried at -60°C to obtain white nanocrystalline cellulose.

[0045] (2) Preparation of polylactic-glycolic acid (PLGA) solution

[0046] Draw 5mL of hexafluoroisopropanol solution and pour it into a container containing 0.75g of polylactic-glycolic acid (PLGA, LA / GA=75 / 25, Mv=5000), quickly close the bottle cap, and place it on a magnetic stirrer Stir until the polylactic glycolic acid (PLGA) in the container is completely dissolved, and the solution is transparent and clear;

[0047] (3) Preparation of electrostatic spinning emulsion dispersion

[0048] Add 0.0225g nan...

Embodiment 3

[0052] (1) Preparation of nanocrystalline cellulose

[0053] Weigh 15g of microcrystalline cellulose powder, add it to 140mL of 65wt% concentrated sulfuric acid, and mechanically stir it in a water bath at 40°C for 6 hours. Ultrasonic dispersion, followed by repeated dialysis with water three times until the pH value is stable, the dialyzed sample was placed in a refrigerator at 4°C overnight, and then freeze-dried at -60°C to obtain white nanocrystalline cellulose.

[0054] (2) Preparation of polylactic-glycolic acid (PLGA) solution

[0055] Draw 5mL of hexafluoroisopropanol solution and pour it into a container containing 1.0g of polylactic-glycolic acid (PLGA, LA / GA=75 / 25, Mv=5000), quickly close the bottle cap, and place it on a magnetic stirrer Stir until the polylactic glycolic acid (PLGA) in the container is completely dissolved, and the solution is transparent and clear;

[0056] (3) Preparation of electrostatic spinning emulsion dispersion

[0057] Add 0.05g of nan...

Embodiment 4

[0061] (1) Preparation of nanocrystalline cellulose

[0062] Weigh 15g of microcrystalline cellulose powder, add it to 140mL of 65wt% concentrated sulfuric acid, and mechanically stir it in a water bath at 40°C for 6 hours. Ultrasonic dispersion, followed by repeated dialysis with water three times until the pH value is stable, the dialyzed sample was placed in a refrigerator at 4°C overnight, and then freeze-dried at -60°C to obtain white nanocrystalline cellulose.

[0063] (2) Preparation of polylactic-glycolic acid (PLGA) solution

[0064] Draw 5 mL of hexafluoroisopropanol solution and pour it into a container containing 1.25 g of polylactic-glycolic acid (PLGA, LA / GA=75 / 25, Mv=5000), quickly close the bottle cap, and place it on a magnetic stirrer Stir until the polylactic glycolic acid (PLGA) in the container is completely dissolved, and the solution is transparent and clear;

[0065] (3) Preparation of electrostatic spinning emulsion dispersion

[0066] Add 0.0875g o...

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Abstract

The invention discloses a nanometer microcrystalline cellulose reinforcing polylactic acid glycolic acid electrospun membrane, a preparation method thereof and application and relates to the field of biomedicine. Two natural organic polymer materials of PLGA and CNCs are composited, the method of preparing the electrospun film through electrospinning can effectively enhance the strength and the bioactivity of the materials, give full play to the biological nanometer effect and effectively compensate for the limitation of pure PLGA in biomedical application, and wound healing is well facilitated. In addition, the CNCs reinforcing PLGA electrospun membrane prepared through the method can also be used in fields of medicine controlled slow-release, repair of organs, such as skin, nerve and heart, tissue regeneration and the like.

Description

technical field [0001] In the field of biomedicine, the invention specifically relates to a nano-microcrystalline cellulose-reinforced poly(lactic-co-glycolic acid) electrospun membrane, a preparation method thereof, and an application thereof. Background technique [0002] Cellulose is the most abundant renewable resource in nature. It mainly exists in various plants and other agricultural by-products. It is a kind of cheap and sustainable polymer material. In today's world where the environment is deteriorating, it is of great significance to develop and use biodegradable cellulose resources. Historically, cellulose was the main research object during the birth and development of polymer chemistry. The results of cellulose research have made important contributions to the establishment and development of polymer science. In particular, the properties of cellulose that can be processed and modified into materials for different applications are well understood. Nowadays, c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D01D5/00
CPCD04H1/728D01D5/00D01D5/0007D01D5/0015
Inventor 郭瑞熊胜全
Owner BEOGENE BIOTECH GUANGZHOU
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