Production method of sugar-reducing polysaccharide granules with coprinus comatus

A technology of Coprinus comatus polysaccharides and granules, which is applied in polysaccharide/gum-containing food ingredients, pharmaceutical formulas, and functions of food ingredients. It can solve the problems of cumbersome administration, inconvenient operation, and large body irritation, and achieve stable drug content. , Less hygroscopicity, easy to use

Inactive Publication Date: 2015-04-29
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of the above Coprinus comatus polysaccharide dosage form has certain limitations, such as the oral liquid dosage form is cumbersome to administer, the operation is inconvenient, and the injection dosage form is highly irritating to the body, etc.

Method used

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  • Production method of sugar-reducing polysaccharide granules with coprinus comatus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 Coprinus comatus polysaccharide granule

[0026] Prepare as follows:

[0027] (1) Coprinus comatus polysaccharide (purchased from Hangzhou Zhonggu Shannian Biotechnology Co., Ltd., the specification is 10g / bag, the same below), sugar powder (purchased from Tianjin Bodi Chemical Co., Ltd., the specification is 25kg / bag, the same below) , hydroxypropylmethylcellulose (purchased from Anhuishanhe Pharmaceutical Excipients Co., Ltd., the specification is 25kg / bag), etc. are dried and pulverized respectively; Coprinus comatus polysaccharide is passed through a 100-mesh sieve, and sugar powder and hypromellose are passed through a 100-mesh sieve. 80 mesh sieve for standby.

[0028] (2) Put 60g of Coprinus comatus polysaccharide and 720g of powdered sugar in a mixer, then gradually add 360g of hydroxypropyl methylcellulose and 60g of water, and mix well to make soft material; pass the soft material through a 16-mesh sieve to make wet granules ,...

Embodiment 2

[0029] The preparation of embodiment 2 Coprinus comatus polysaccharide granules

[0030] Prepare as follows:

[0031] (1) Coprinus comatus polysaccharide, mannitol (purchased from Henan Huasen Biotechnology Co., Ltd., the specification is 25kg / bag), dextrin (purchased from Shanxi Xiwang Sugar Co., Ltd., the specification is 25kg / bag) etc. are dried separately , crushed; Coprinus comatus polysaccharide passed through a 100-mesh sieve, dextrin and mannitol passed through an 80-mesh sieve for later use;

[0032] (2) Put 50g of Coprinus comatus polysaccharide and 1250g of mannitol in a mixer, gradually add 300g of dextrin and 40g of water, and mix well to make a soft material; pass the material through a 16-mesh sieve to make wet granules, and then drum at 60°C After air-drying, use 20 meshes to granulate, then subpackage, seal, and pack to obtain Coprinus comatus polysaccharide granules.

Embodiment 3

[0033] The preparation of embodiment 3 Coprinus comatus polysaccharide granules

[0034] (1) Coprinus comatus polysaccharide, powdered sugar, povidone K30 (purchased from Xi'an Yuelai Pharmaceutical Technology Co., Ltd., specification: 25kg / barrel) were dried and crushed respectively; Coprinus comatus polysaccharide was passed through a 100-mesh sieve, powdered sugar, poly Pass Vitone K30 through an 80-mesh sieve for later use;

[0035] (2) Put 30g of Coprinus comatus polysaccharide and 420g of powdered sugar in a mixer, gradually add 120g of povidone K30 and 30g of water, and mix well to make a soft material; pass the soft material through a 16-mesh sieve to make wet granules, and then 60°C After blasting and drying, granulate with 20 meshes, then subpackage, seal and pack to obtain Coprinus comatus polysaccharide granules.

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Abstract

The invention discloses polysaccharide granules with coprinus comatus and a preparation method thereof. The polysaccharide granules with the coprinus comatus are prepared by adopting the coprinus comatus produced on the market and adopting other auxiliary materials. The proportion of all the components is shown in the specification. The polysaccharide granules and the preparation method disclosed by the invention have the advantages that the developed polysaccharide granules with the coprinus comatus are convenient in use and can be taken by adding water; the produced polysaccharide with the coprinus comatus has obvious activity of reducing the blood sugar; the components of the polysaccharide with the coprinus comatus act on the blood sugar directly, can not generate influence on the pancreatic function of a human body, so that the effect for 1-type diabetes needing to injection of insulin is bad, but after a patient with early stage of 2-type diabetes or maintenance of higher blood sugar eats for 1-3 days continuously, the sugar-reducing effect is obvious; and a product developed by utilizing the polysaccharide has obvious health-care function and also has extremely-large development space.

Description

technical field [0001] The invention relates to a health food and a preparation method thereof, in particular to a Chinese medicine formula granule health food. Background technique [0002] Coprinus comatus scientific name Coprinus comatus, also known as Coprinus comatus, belongs to the phylum Fungi, Basidiomycotina, Phytomycetes, Agaricaceae, Coprinus family, Coprinus genus. It is named after its shape like a chicken leg, and its meat tastes like chicken shreds. It is a rare edible fungus with commercial potential developed and produced artificially in recent years. It has been identified by the World Health Organization and the Food and Agriculture Organization of the United Nations as a collection of "natural, nutritious, It is one of the 16 rare edible fungi with three functions in one, and it is recommended for vigorous promotion. Because Coprinus comatus has the characteristics of high protein, low fat, and a complete range of amino acids, it is known as a "rookie of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/09A23L1/28A61K9/16A61K31/715A61P3/10A23L29/30A23L31/00
CPCA23L29/30A23V2002/00A23V2250/208A23V2250/51A23V2200/328
Inventor 韩春超王伟马艳妮
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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