Carbocisteine composition freeze-drying tablet and preparation method thereof
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A technology of carbocisteine and a composition is applied in the field of carbocisteine composition freeze-dried tablet and preparation thereof, and achieves the effects of ensuring curative effect and safety, large dissolution rate and high bioavailability
Inactive Publication Date: 2015-04-29
HAINAN WEI KANG PHARMA QIANSHAN
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[0008] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on the production of carbocisteine freeze-dried tablets by freeze-drying process
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Embodiment 1
[0027]
[0028] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V ) of cornstarch solution.
[0029] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.
[0030] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.
[0031] D. Weigh 100 g of carbocisteine, add it into 1 L of corn-sucrose solution, and stir for 30 minutes.
[0032] E. After measuring the content of carbocisteine in the medicina...
Embodiment 2
[0035]
[0036] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 13% (W / V) cornstarch solution.
[0037] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.
[0038] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.
[0039] D, take by weighing 100 grams of carbocisteine (calculated as 1000 tablets), add 1L of corn-sucrose solution, and stir for 30 minutes.
[0040] E. After measuring the content ...
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Abstract
The invention provides a carbocisteine composition freeze-drying tablet and a preparation method thereof, and relates to technical fields of medicines and medicine production. The carbocisteine composition freeze-drying tablet comprises carbocisteine, starch and cane sugar, wherein the starch and cane sugar are taken as auxiliary materials; by performing heating technology processing on the common corn starch, the binding effect and disintegration effect of the starch in the tablet can be improved, the formability of the tablet can be improved, and the carbocisteine composition freeze-drying tablet only requires two auxiliary materials, namely starch and cane sugar. The carbocisteine composition freeze-drying tablet adopts a freeze-drying technology of twice cooling and twice heating up which can ensure that the formability of the tablet is better, and improves the dissolution rate of the tablet, so that the bioavailability of the tablet is improved; the tablet overcomes the disadvantage of the common carbocisteine tablet, reduces the variety and the use level of the auxiliary materials in the carbocisteine tablet, is high in dissolution rate and high in bioavailability, and guarantees the curative effect and safety of clinical medication.
Description
technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a carbocisteine composition freeze-dried tablet and a preparation method thereof. Background technique [0002] Carbocisteine is used for the treatment of diseases such as thick sputum, difficulty in coughing up sputum, and phlegm blocking the airway caused by chronic bronchitis, bronchial asthma and other diseases. As a mucus regulator, it mainly acts on the secretion of bronchial glands, increasing the secretion of low-viscosity salivary mucin and reducing the production of high-viscosity fucoidal mucin, thus reducing the viscosity of sputum and making it easier to cough up. [0003] structural formula [0004] Molecular weight: 179.19 [0005] Ordinary carbocisteine tablets contain many types and quantities of excipients. Generally, fillers, lubricants, disintegrants, binders, flavoring agents, etc. are used. According to the second volume of...
Claims
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