Compound Chansu injection and preparation method thereof

A technology for injection and toad flakes, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as the lack of antiviral drugs, and achieve improved immunity and good health. , the effect of improving immunity

Active Publication Date: 2018-02-02
河南天纳图实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition, since 2006, the Ministry of Agriculture has issued a document to completely prohibit the use of antiviral drugs such as amantadine and ribavirin in veterinary drugs, resulting in the lack of antiviral drugs that can be used in veterinary drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A compound toad venom injection, made from the following raw materials in weight percentage: 1.1% of toad venom (dry product), 10% of acidified distillate of compound Beibupleurum and Asarum, 1.5% of sodium γ-hydroxybutyrate, polysorbate Ester-80 0.5%, sodium chloride 0.8%, propylene glycol 1%, anhydrous sodium sulfite 0.2%, benzyl alcohol 1%, edetate disodium 0.5%, and the balance is water (water for injection).

[0031] Carry out relevant test to present embodiment's compound toad venom injection as follows:

[0032] (1) Temperature acceleration test:

[0033] Test method: This experiment studies the accelerated experiment (6 months) of Compound Chansu Injection at 50°C. The compound Chansu injection (3 batches) was packaged according to the market, placed in a closed desiccator filled with saturated sodium chloride solution (relative humidity was about 75%), and then the desiccator was placed in a water-proof electric heating constant temperature incubator maintain...

Embodiment 2

[0049] A compound toad venom injection, made from the following raw materials in weight percentage: 1.0% of toad venom, 8% of acidified distillate of compound Bei Bupleurum and Asarum, 1.4% of sodium γ-hydroxybutyrate, 0.3% of polysorbate-80 %, sodium chloride 0.5%, propylene glycol 0.8%, anhydrous sodium sulfite 0.15%, benzyl alcohol 0.8%, edetate disodium 0.4%, and the balance is water (water for injection).

[0050] The toad venom is a dry product; the water is water for injection; the acidified distillate of the compound Bupleuri and Asarum is the same as in Example 1.

Embodiment 3

[0052] A compound toad venom injection, made from the following raw materials in weight percentage: 1.3% of toad venom, 12% of acidified distillate of compound Beibupleuri and Asarum, 1.6% of sodium γ-hydroxybutyrate, 0.6% of polysorbate-80 %, sodium chloride 1.0%, propylene glycol 1.2%, anhydrous sodium sulfite 0.25%, benzyl alcohol 1.2%, edetate disodium 0.7%, and the balance is water.

[0053] The toad venom is a dry product; the water is water for injection; the acidified distillate of the compound Bupleuri and Asarum is the same as in Example 1.

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PUM

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Abstract

The invention belongs to the field of veterinary medicines, in particular relates to a composite venenum bufonis injection and a preparation method thereof, and mainly aims at treating diseases caused by virus, bacteria and mycoplasma infection of livestock. The composite venenum bufonis injection is prepared from the following raw materials in percentage by weight: 1.0-1.3% of venenum bufonis, 8-12% of acidification distillate of composite bupleurumchinense and asarum sieboldi, 1.4-1.6% of gamma-sodium hydroxybutyrate, 0.3-0.6% of polysorbate-80, 0.5-1.0% of sodium chloride, 0.8-1.2% of propylene glycol, 0.15-0.25% of anhydrous sodium sulfite, 0.8-1.2% of benzyl alcohol, 0.4-0.7% of ethylenediamine tetraacetic acid and the balance of water. The composite venenum bufonis injection can be used as a special medicine preparation with double effects of acid antiviral property and immunity improvement, and is very large in market demand, safe and free of residue, and remarkable in social benefit; due to the preparation method, the process is simplified, and the use method, the dosage and the treatment effect are ensured.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and in particular relates to a compound toad venom injection and a preparation method thereof, which are mainly used for treating diseases caused by infection of viruses, bacteria and mycoplasma in livestock and poultry. Background technique [0002] According to the "Regulations on the Administration of Veterinary Drugs", the state encourages the development of new veterinary drugs to ensure food safety, reduce and eliminate the harm of drug residues to human health, and adhere to the development direction of veterinary drug manufacturers with high starting point, high technology and high quality. However, the current veterinary drug production field has low product safety, simple preparation process, and low technological content, and a large number of companies compete at a low level. Therefore, it is necessary to gradually eliminate veterinary drug products with backward production technolo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/264A61P31/04A61P31/12A61P37/04A61P29/00A61P9/04A61P11/06A61P11/04A61P11/14A61P35/00A61K36/233A61K35/65
CPCA61K9/0019A61K9/08A61K35/65A61K36/233A61K36/268A61K47/10A61K47/183A61K47/20A61K47/26A61K2300/00Y02A40/70
Inventor 沈永恕唐光武吴玉臣陈益曹素芳杨荣恩郭素琴娄飞蒋增海
Owner 河南天纳图实业有限公司
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