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Adjustable spectrum gold nanoshell preparation method

A gold nanoshell and spectrum technology, applied in the field of gold nanoshell preparation, can solve the problems of harsh synthesis conditions, unstable particles, cumbersome steps, etc., and achieve fast response, simple operation, and good repeatability

Inactive Publication Date: 2015-04-29
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The synthetic conditions of this gold nanoshell particle method are relatively harsh, and the steps are relatively cumbersome, and the synthesized particles are unstable in acidic conditions and physiological environments.

Method used

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  • Adjustable spectrum gold nanoshell preparation method
  • Adjustable spectrum gold nanoshell preparation method
  • Adjustable spectrum gold nanoshell preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Add 0.01mL (42.7×10 -3 mmol) aminopropyltriethoxysilane, stirred for 10 s, then added 0.1 mL of 25 mM tetrachloroauric acid aqueous solution, stirred for 20 s, added 0.4 mL of 0.1 M fresh sodium borohydride aqueous solution at 4 °C, and then added 0.4 Bovine serum albumin with a mL concentration of 0.1 mM is used as a stabilizer to obtain gold nanoshell particles with an average particle diameter of 37 nm and a particle surface plasmon resonance absorption peak at 657 nm.

Embodiment 2

[0029] Add 0.01mL of aminopropyltriethoxysilane to 4.8mL of water, stir for 10s, then add 0.2mL of 25mM tetrachloroauric acid aqueous solution, stir for 20s, add 0.4mL of 0.1M fresh sodium borohydride at 4°C aqueous solution, and then add 0.4mL bovine serum albumin with a concentration of 0.1mM as a stabilizer to obtain gold nanoshell particles with an average particle diameter of 42nm and a particle surface plasmon resonance absorption peak at 720nm.

Embodiment 3

[0031] Add 0.01mL of aminopropyltriethoxysilane to 4.7mL of water, stir for 10s, then add 0.3mL of 25mM tetrachloroauric acid aqueous solution, stir for 20s, add 0.4mL of 0.1M fresh sodium borohydride at 4°C aqueous solution, and then add 0.4 mL of bovine serum albumin with a concentration of 0.1 mM as a stabilizer to obtain gold nanoshell particles with an average particle diameter of 61 nm and a particle surface plasmon resonance absorption peak at 755 nm.

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Abstract

The invention provides an adjustable spectrum gold nanoshell preparation method, and belongs to the technical field of preparation of nanometer materials. The method comprises the steps of dispersing aminopropyltriethoxysilane into a solvent and agitating round intensely, wherein the solvent is water or the mixed solvent of alcohol and water; then quickly adding a chloroauric acid hydrated aqueous solution; adding a reducing agent while agitating round intensely; then adding a stabilizer to obtain nanoshell particle sol; the reducing agent is sodium borohydride; the stabilizer is bovine serum albumin. According to the method, the dosage of chloroauric acid hydrated or the alcohol and water ratio in the system can be adjusted to adjust the core and shell ratio of the gold nanoshell, and therefore, the position of plasma resonance-absorption peak of a product can be adjusted. The method has the advantages of being simple to operate, fast to react, mild in reaction, high in repeatability, and low in cost.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, in particular to a method for preparing a gold nanoshell with adjustable spectrum. Background technique [0002] Gold nanoshell particles synthesized from tetrachloroauric acid under aqueous conditions by template method can be applied to tumor photothermal therapy due to their good chemical stability, biocompatibility, and unique optical and photothermal conversion properties. In biological applications, compared with visible light, near-infrared has better penetration; since the optical properties of gold nanoshell particles depend on their core-shell size ratio, by properly adjusting the core-shell ratio, synthesized gold nanoshell particles with plasmon resonance absorption Gold nanoshell particles with peaks in the near-infrared region will be more conducive to their application in photothermal therapy. [0003] At present, the most classic method for synthesizing gold nano...

Claims

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Application Information

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IPC IPC(8): B22F9/24
Inventor 管亚男梁经纶薛峥庄家骐杨文胜
Owner JILIN UNIV