A polylactic acid composite material for promoting bone growth and biocompatibility and its preparation method

A technology of biocompatibility and composite materials, applied in the field of polylactic acid composite materials and preparations that promote bone growth and biocompatibility, can solve the problem that the stability is not enough to alleviate the acidic environment of PLA, unfavorable cell growth and adhesion, Low cytocompatibility and other issues, to achieve considerable economic benefits, reduce the cost of bone repair, and good biocompatibility

Active Publication Date: 2017-01-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Coupling agents can be used to increase the degradation rate of PLA, so in "Materials science & engineering C, Materials for biological applications, 2012, 32(6): 1428-36", PLA / HA composites are prepared after pretreatment of HA with coupling agents, but Shows low cytocompatibility, which is attributed to the generation of acidic and toxic small molecules after PLA degradation, which is not conducive to cell growth and adhesion locally
In addition, the very high stability of HA is not enough to alleviate the acidic environment caused by PLA

Method used

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  • A polylactic acid composite material for promoting bone growth and biocompatibility and its preparation method
  • A polylactic acid composite material for promoting bone growth and biocompatibility and its preparation method
  • A polylactic acid composite material for promoting bone growth and biocompatibility and its preparation method

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Effect test

Embodiment 1

[0035] A method for preparing a polylactic acid composite material that promotes bone growth and biocompatibility, comprising:

[0036] (1) Surface activation treatment of pearl powder

[0037] Pearl powder with a particle size of 100nm is added to deionized water, and polyethylene glycol powder with a degree of polymerization of 4000Da is added at the same time. The mass ratio of polyethylene glycol to pearl powder is 2:98. The mass of the two is equal to the mass of deionized water. The ratio is 1:10. After stirring and ultrasonication, freeze at -15°C for 12h, wherein the stirring rate is 1000rpm, the ultrasonic power is 50KHz, and the time is 0.5h each, and then freeze-dry at -55°C for 20h to obtain polyethylene oxide. Diol surface modified pearl powder;

[0038] (2) Preparation of polylactic acid composite material;

[0039] Polylactic acid with a weight-average molecular weight of 70,000 is dissolved in chloroform solvent to form a solution with a mass fraction of 5 wt...

Embodiment 2

[0042] A method for preparing a polylactic acid composite material that promotes bone growth and biocompatibility, comprising:

[0043] (1) Surface activation treatment of pearl powder

[0044] Pearl powder with a particle size of 400nm is added to deionized water, and polyethylene glycol powder with a degree of polymerization of 10000Da is added at the same time. The mass ratio of polyethylene glycol to pearl powder is 5:95. The mass of the two is equal to the mass of deionized water. The ratio is 1:20. After stirring and ultrasonication, freeze at -20°C for 15h, wherein the stirring rate is 500rpm, the ultrasonic power is 40KHz, and the time is 1h each, and then freeze-dry at -45°C for 24h to obtain polyethylene glycol. Alcohol surface modified pearl powder;

[0045] (2) Preparation of polylactic acid composite material;

[0046] Polylactic acid with a weight-average molecular weight of 200,000 is dissolved in 1,4-dioxane solvent to form a solution with a mass fraction of ...

Embodiment 3

[0049] A method for preparing a polylactic acid composite material that promotes bone growth and biocompatibility, comprising:

[0050] (1) Surface activation treatment of pearl powder

[0051] Pearl powder with a particle size of 300nm is added to deionized water, and polyethylene glycol powder with a degree of polymerization of 5000Da is added at the same time. The mass ratio of polyethylene glycol to pearl powder is 2:98. The mass of the two and the mass of deionized water The ratio is 1:18. After stirring and ultrasonication, freeze at -16°C for 12h, wherein, the stirring rate is 600rpm, the ultrasonic power is 45KHz, and the time is 0.6h each, and then freeze-dry at -50°C for 22h to obtain polyethylene oxide. Diol surface modified pearl powder;

[0052] (2) Preparation of polylactic acid composite material;

[0053] Polylactic acid with a weight-average molecular weight of 150,000 was dissolved in 1,4-dioxane solvent to form a solution with a mass fraction of 8 wt%, and...

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Abstract

The invention relates to a polylactic acid composite material for promoting bone growth and biocompatibility and a preparation method of the polylactic acid composite material. The preparation method comprises the following steps: by adopting polylactic acid and pearl powder as raw materials, dissolving by a solvent, and carrying out magnetic stirring, ultrasonic dispersion, solvent evaporation and solvent desorption to obtain the pearl-powder-containing modified polylactic acid composite material. The material is soaked in a simulated body fluid (SBF); by adopting a biomimetic mineralization technology, hydroxyapatite (HA) grows on the material. Result shows that the material product has favorable stability and uniformity; due to the presence of the pearl powder, the growth velocity of the HA is remarkably improved; along with the content addition of the pearl powder, the mineralization speed of the HA is continuously improved. A test through an MTT method proves that the biocompatibility and the cell relative growth rate of the material is improved to a large extent on the basis of pure polylactic acid due to the presence of the pearl powder; and the enhancing effect of the composite material with high pearl powder content is more considerable. The composite material shows bright prospect as a bone repair material.

Description

technical field [0001] The invention belongs to the technical field of composite materials, and relates to a polylactic acid composite material for promoting bone growth and biocompatibility and a preparation method thereof, in particular to a polylactic acid compound compounded with pearl powder and polylactic acid, which has the ability to induce hydroxyapatite growth and biocompatibility. Compatibility improved double-effect polylactic acid composite material and its preparation method, specifically, a polylactic acid dispersed with polyethylene glycol surface-modified pearl powder with the ability to induce hydroxyapatite growth and biocompatibility Performance-improving dual-function polylactic acid composite material and its preparation method. Background technique [0002] With the continuous development of material science, more and more materials have entered the medical field as biomedical materials to repair defects in various parts of the human body, and bone rep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04C08K9/04C08K3/34C09C1/28C09C3/10C09C3/04A61L27/44A61L27/54A61L27/58
Inventor 李光戴家木白敬敬邓研辉金俊弘杨胜林江建明
Owner DONGHUA UNIV
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