The controlled releasing method by using active pearl material instead of bone growth factors in the bone restoration

A technology of bone growth factors and active substances, which is applied in the field of controlled release of bone growth factors replaced by pearl active substances in bone repair, can solve the problems of reduced activity of pearls, and achieve scale, simple production process, and wide sources Effect
CN100438930CInactive Publication Date: 2008-12-03TSINGHUA UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TSINGHUA UNIV
Publication Date
2008-12-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the biomedical materials technology, especially relates to a controlled release method to replace bone growth factor with pearl active substances in bone repair. By means of the pure pearl active substance extraction contained within bone material and different dissolution rate with different grain size and content of pearl powder in the body, the material degradation in different stages in bone repair: at the early stage, rapidly activate the bone system as a start-up factor and accelerator in bone repair; subsequently, the pearl powder start to dissolve, but small particles pearl powder dissolve faster, consumed earlier, and the large particles of pearl powder dissolve slowly, consumed after that, in this way, pearl powder with different granularities degrade at different stages in bone repair, thus the pearl active substances can be continuous released in bone repair process, and can be control to release through active substance of pearl extraction and regulation of content and particle size of pearl powder. The screened and packed pearl powder and its combination are of simple production technology, easy to enlarge scale by the invention.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical materials, in particular to a controlled release method for replacing bone growth factors with pearl active substances in bone repair. Background technique

[0002] Bone aging and accidental damage are often inevitable, and the diseased bone will eventually be replaced. Bone implant repair is a human tissue transplant second only to blood transfusion. At present, various artificial bone repair substitute materials emerge in endlessly, but they mainly function as bone scaffolds and do not have the unique osteoinductive activity of bone growth factors. Liu Zhiqiang, Zhou Dongfeng, Zhou Lei, etc. reported in the "Research and Progress of Bone Defect Repair" on "Guangdong Dental Disease Prevention and Treatment, 2004, 12(1): 73-75". In fact, the bone repair process that people expect is : A variety of growth factors and activators are released in a controlled manner at the site to be repaired, ind...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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