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The controlled releasing method by using active pearl material instead of bone growth factors in the bone restoration

A technology of bone growth factors and active substances, which is applied in the field of controlled release of bone growth factors replaced by pearl active substances in bone repair, can solve the problems of reduced activity of pearls, and achieve scale, simple production process, and wide sources Effect

Inactive Publication Date: 2008-12-03
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dissolution of pearls generally uses chemical reagents such as weak acids and enzymes to dissolve calcium carbonate, so that although the organic components of pearls can be exposed to the maximum, the activity of pearls will inevitably be greatly reduced.

Method used

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  • The controlled releasing method by using active pearl material instead of bone growth factors in the bone restoration
  • The controlled releasing method by using active pearl material instead of bone growth factors in the bone restoration
  • The controlled releasing method by using active pearl material instead of bone growth factors in the bone restoration

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the natural degradation of pearl powder

[0029] Once the pearl powder is nano-sized, its degradation speed and degradation degree will be greatly improved. Obviously, the degradation of pearl powder must be closely related to its unique nano-organic-inorganic hierarchical structure, which is similar to that of pure CaCO 3 In contrast, the degradation of pearl powder must have its particularity, and the degradation of pearl powder will also have size dependence. The present invention is to nanopearl powder (NPP, main particle diameter is about 50-150nm, micron pearl powder (MPP, main particle diameter is about 1-5 μm) and pure CaCO 3 Reagent powder (MCP, about 1 μm in size) was subjected to degradation experiments in flowing deionized water, and the experimental equipment was as follows: figure 1 shown. The original forms of the three powders are as figure 2 shown. The pearl powder used is the product of Zhejiang Changshengniao Pharmaceutical Co., Lt...

Embodiment 2

[0039] The superfine pearl powder product (component I) and nano pearl powder product (component II) of Changshengniao Pharmaceutical Co., Ltd. were vacuum-dried at 60°C for 3 hours, wherein the main particle size of the superfine pearl powder was about 1- 5 μ m, the main particle diameter of nano pearl powder is about 50-150nm, component I and component II get 4 grams (40%wt.%) and 6 grams (60%wt.%) respectively, and then they are placed together in agate Mix in a mortar for 1 hour to obtain a composition of the two, and vacuum-dry the composition at 60° C. for 2 hours, and finally pack and sterilize the composition for use.

Embodiment 3

[0041] Common micron pearl powder purchased in the market was vacuum-dried at 60°C for 3 hours, then sieved with a vibrating sieve at -100 mesh and +120 mesh to obtain pearl powder (component I) with a diameter of 132 μm to 154 μm, and then Sieve -120 mesh pearl powder -325 mesh and +350 mesh to obtain pearl powder (component II) with a diameter of 48 μm ~ 50 μm. The superfine pearl powder product (component III) and nano pearl powder product (component IV) of Changshengniao Pharmaceutical Co., Ltd. were vacuum-dried at 60°C for 3 hours, wherein the main particle size of the superfine pearl powder was about 1- 5 μ m, the main particle diameter of nano pearl powder is about 50-150nm; 10%wt.%), 2g (20%wt.%), 3g (30%wt.%), 3g (30%wt.%), and then they were mixed together in an agate mortar for 1 hour to The five compositions were obtained, and the compositions were vacuum-dried at 60° C. for 2 hours, and finally the compositions were packaged and sterilized for use.

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Abstract

The invention belongs to the biomedical materials technology, especially relates to a controlled release method to replace bone growth factor with pearl active substances in bone repair. By means of the pure pearl active substance extraction contained within bone material and different dissolution rate with different grain size and content of pearl powder in the body, the material degradation in different stages in bone repair: at the early stage, rapidly activate the bone system as a start-up factor and accelerator in bone repair; subsequently, the pearl powder start to dissolve, but small particles pearl powder dissolve faster, consumed earlier, and the large particles of pearl powder dissolve slowly, consumed after that, in this way, pearl powder with different granularities degrade at different stages in bone repair, thus the pearl active substances can be continuous released in bone repair process, and can be control to release through active substance of pearl extraction and regulation of content and particle size of pearl powder. The screened and packed pearl powder and its combination are of simple production technology, easy to enlarge scale by the invention.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a controlled release method for replacing bone growth factors with pearl active substances in bone repair. Background technique [0002] Bone aging and accidental damage are often inevitable, and the diseased bone will eventually be replaced. Bone implant repair is a human tissue transplant second only to blood transfusion. At present, various artificial bone repair substitute materials emerge in endlessly, but they mainly function as bone scaffolds and do not have the unique osteoinductive activity of bone growth factors. Liu Zhiqiang, Zhou Dongfeng, Zhou Lei, etc. reported in the "Research and Progress of Bone Defect Repair" on "Guangdong Dental Disease Prevention and Treatment, 2004, 12(1): 73-75". In fact, the bone repair process that people expect is : A variety of growth factors and activators are released in a controlled manner at the site to be repaired, ind...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/22A61L27/50
Inventor 朱静申玉田凌涛阮华君
Owner TSINGHUA UNIV
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