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An orally disintegrating preparation

An oral disintegration and preparation technology, applied in the field of pharmaceutical preparations, can solve the problems of mad cow virus hidden dangers such as gelatin safety, high production costs, and hidden dangers, and achieve the effects of improving drug safety, taking convenience, and absorbing quickly

Inactive Publication Date: 2017-08-01
BEIJING FUYUAN GLOBAL BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide an orally disintegrating preparation to solve the current problems of difficulty and discomfort in swallowing medicines for patients with ALS disease, children, and the elderly. At the same time, the orally disintegrating preparation of the present invention uses imported The artificial synthesis of praslin from artificial raw materials results in high production costs, as well as potential safety hazards in the use of gelatin as an auxiliary material, which has hidden dangers of mad cow virus and heavy metal chromium.

Method used

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  • An orally disintegrating preparation

Examples

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Effect test

Embodiment 1

[0019] An orally disintegrating preparation provided by the invention comprises:

[0020] Therapeutic drugs 40g (8%)

[0021] Collagen Peptides 60g (12%)

[0022] Sugar alcohol 375g (75%)

[0023] Add other conventional auxiliary materials such as flavoring agents and lubricants in an appropriate amount. The above-mentioned percentages are percentages by weight, and the amount of 1000 preparations.

[0024] The orally disintegrating preparation of this embodiment is prepared by the following steps:

[0025] (1) Collagen peptide and sugar alcohol are dried and pulverized, and mixed through a 100-mesh sieve;

[0026] (2) Mix the medicine for treatment with the adjuvant of step (1) to prepare pellets by wet method, pass through a 40-mesh sieve, and mix uniformly;

[0027] (3) The mixture obtained in step (2) is directly compressed into tablets.

[0028] In this embodiment, the therapeutic drug is a benzothiazole drug, which is used for the treatment of patients with amyotro...

Embodiment 2

[0034] An orally disintegrating preparation provided by the invention comprises:

[0035] Drugs for treatment 50g (10%)

[0036] Collagen Peptides 90g(18%)

[0037] Sugar alcohol 300g (60%)

[0038] Others are the same as in Embodiment 1, and will not be repeated here.

Embodiment 3

[0040] An orally disintegrating preparation provided by the invention comprises:

[0041] Therapeutic drugs 15g (3%)

[0042] Collagen Peptides 25g (5%)

[0043] Sugar alcohol 400g (80%)

[0044] Others are the same as in Embodiment 1, and will not be repeated here.

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Abstract

The invention provides an orally disintegrating preparation. The orally disintegrating preparation comprises treatment medicines and auxiliary materials, wherein the auxiliary materials comprise collagen peptide and sugar alcohol, the treatment medicines account for 3%-20% of the total weight, the collagen peptide accounts for 2%-18% of the total weight, and the sugar alcohol accounts for 15%-80% of the total weight. The orally disintegrating preparation aims to solve the problem that medicines are difficult to swallow by ALS patients, children, old people and the like, meanwhile, a conventional auxiliary material, namely, gelatin, of the orally disintegrating preparation is abandoned, and the BSE (bovine spongiform encephalopathy) virus danger and the heavy metal chromium problem caused by the gelatin arouse wide concern.

Description

technical field [0001] The invention belongs to pharmaceutical preparations, in particular to an orally disintegrating preparation. Background technique [0002] Amyotrophic lateral sclerosis, also known as ALS disease, ALS, also known as "motor neuron disease" in the UK, is a type of motor neuron disease that affects upper motor neurons (brain, brainstem, Spinal cord), a chronic progressive degenerative disease affecting the lower motor neurons (cranial nerve nuclei, anterior horn cells of the spinal cord) and the muscles of the trunk, extremities, and head and face innervated by them. ALS disease usually starts with hand muscle weakness and atrophy, which usually starts from one side and then spreads to the opposite side. As the disease progresses, symptoms of mixed damage to upper and lower motor neurons appear, accompanied by symptoms such as dysphagia and malnutrition. [0003] Although the pathogenesis of the ALS condition has not been fully elucidated, glutamate toxi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K47/26A61K31/428A61P25/00A61K9/20
Inventor 郁实
Owner BEIJING FUYUAN GLOBAL BIOTECH