Preparation method of multi-antibiotics premix

A technology of multi-antibiotics and premixes, which is applied in the fields of botanical equipment and methods, fungicides, biocides, etc., can solve the problems of poor stability of multi-antibiotic finished products, and achieve convenient storage and application, improved stability, and improved production efficiency. The effect of grain rate and yield improvement

Active Publication Date: 2015-05-20
NANJING UNIV OF TECH
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem of weak stability of multi-antibiotic finished products, the present invention provides a preparation method of multi-antibiotic premix which is simple, low in cost and obviously improves the stability of the obtained product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Pretreatment: Take 1000L of fermented multi-antibiotic fermentation broth (fermentation titer is 2140μg / mL) and heat it to 60°C, keep it for 5min, cool down, adjust the pH to 2.5 with hydrochloric acid, add 1.5% of the mass of the fermentation broth Copper sulfate is used as a stabilizer, and 0.2% Toween80 of the fermentation broth is used as an auxiliary agent.

[0024] (2) Pressure filtration: carry out plate and frame pressure filtration with the multi-antibiotic fermented liquid after the pretreatment of step (1), control the pressure filtration pressure to be 1.0MPa, and the pressure filtration time is 2h, obtain the multi-antibiotic wet filter cake of water quality 30% 174kg. (3) Flash drying and pulverization: flash drying the wet filter cake obtained in step (2), controlling the inlet air temperature to 110°C, the outlet air temperature to 65°C, and the material temperature to 85°C to obtain multi-antibiotic mycelium after drying Dry product 52.2kg. The we...

Embodiment 2

[0028] (1) Pretreatment: Take 1000L of fermented multi-antibiotic fermentation broth (fermentation titer is 2340μg / mL) and heat it to 65°C, keep it for 7min, cool, adjust the pH to 3.0 with phosphoric acid, add 2.0% of the mass of the fermentation broth Aluminum sulfate is used as a stabilizer, and 0.25% Span 60 of the fermentation broth is used as an auxiliary agent.

[0029] (2) Pressure filtration: carry out plate and frame pressure filtration with the multi-antibiotic fermented liquid after the pretreatment of step (1), control the pressure filtration pressure to be 2.0MPa, and the pressure filtration time is 1.5h, obtain the water quality 34% multi-antibiotic wet filter cake 156kg.

[0030] (3) Flash drying and crushing: The wet filter cake obtained in step (2) is flash dried, the air inlet temperature is controlled to be 120°C, the air outlet temperature is 70°C, and the material temperature is 95°C. After drying, multi-antibiotic mycelium is obtained Dry product 52kg. ...

Embodiment 3

[0035] (1) Pretreatment: Take 1000L of fermented multi-antibiotic fermentation broth (fermentation titer is 2250μg / mL) and heat it to 70°C, keep it for 10min, cool down, adjust the pH to 4.0 with citric acid, add 3.0% of the fermentation broth mass Aluminum chloride is used as a stabilizer, and 0.3% polysorbate 60 of the fermentation broth is used as an auxiliary agent.

[0036] (2) Pressure filtration: carry out plate and frame pressure filtration with the multi-antibiotic fermented liquid after the pretreatment of step (1), the control pressure filtration pressure is 4.5MPa, and the pressure filtration time is 2h, obtains water quality 40% multi-antibiotic wet filter cake 125kg .

[0037](3) Flash drying and crushing: The wet filter cake obtained in step (2) is flash dried, the air inlet temperature is controlled to be 130°C, the air outlet temperature is 60°C, and the material temperature is 100°C, and multi-antibiotic mycelium is obtained after drying Dry product 50kg. T...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Fermentation titeraaaaaaaaaa
Granularityaaaaaaaaaa
Login to view more

Abstract

The invention discloses a preparation method of multi-antibiotics premix. The method comprises the steps of heating fermented multi-antibiotics fermentation liquor up to 60-70 DEG C, and maintaining for 5-10 minutes; cooling, adjusting the pH to 2.5-5.0 by acid, feeding a stabilizing agent and an auxiliary agent, fully stirring, and carrying out plate-frame filtering on the fermented liquor to obtain a multi-antibiotics wet filter cake; then, carrying out flash drying on the filter cake, grinding, feeding auxiliary materials and diluting to obtain the multi-antibiotics premix. The preparation method of the multi-antibiotics premix is simple and easy to operate and low in cost; the stability of the obtained multi-antibiotics premix finished product is obviously improved in the storage process, so that the multi-antibiotics premix is more convenient and stable in the processes of storage, transportation and application.

Description

Technical field: [0001] The invention relates to a preparation method of a multi-antibiotic premix, in particular to a preparation method of a multi-antibiotic premix. Background technique: [0002] Polyoxins, also known as polyoxin, polyoxin, and pleiotropin, are broad-spectrum agricultural antibiotics of peptide pyrimidine nucleosides produced by modern bioengineering technology. Multi-antibiotics have systemic and therapeutic effects and high target biological selectivity, and they can specifically act on common fungal diseases of various crops. The most prominent multi-antibiotic is that it has a strong inhibitory effect on 25 kinds of fungal diseases such as flagella, ascomycetes, and half fungi. Studies have shown that pleiotropin consists of 14 components from A to N. Since 1967, pleiotropin has been widely used as an agricultural fungicide to treat rice sheath blight, tomato gray mold and pear black spot. and other plant fungal diseases. [0003] Pleiotropin has a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A01N47/12A01N25/12A01P3/00
CPCA01N25/12A01N47/12
Inventor 胡永红曹翠翠杨文革杨洋殷晶晶
Owner NANJING UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap