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Preparation method of bacitracin zinc premix

A technology of bacitracin zinc and premix, which is applied in the directions of medical preparations containing active ingredients, cyclic peptide ingredients, and pharmaceutical formulations, can solve the problems of unacceptable livestock and poultry, difficult mixing of feeds, and great dry odor, and achieves the operation Convenience, good fluidity, and the effect of reducing odor

Inactive Publication Date: 2015-05-20
HEBEI SHENGXUE DACHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] ① During the spray drying process, it is easy to cause dust, strong dry odor and high energy consumption;
[0005] ②The product is powder or small granules, with poor fluidity and difficult to mix with feed;
[0006] ③The product has a strong odor and is not easily accepted by livestock and poultry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] a, after the fermented liquid is put into the tank, measure the fermented liquid volume 100L, the total unit of bacitracin is 0.08 billion, add zinc sulfate 0.64Kg according to the ratio of 8Kg / billion units, add 0.5% flavoring agent, 1% flocculant and auxiliary materials simultaneously, After stirring for 0.5h, let it stand for 1h to obtain a mixed solution;

[0030] B, filter the mixed solution obtained in step a with a diaphragm plate and frame filter press, control the filtration pressure to 0.8MPa, filter for 4 hours, and remove the filter cake after the filtration is completed;

[0031] c, the filter cake obtained in step b is granulated through a rotary mixing granulator with a screen aperture of 0.6mm, and the controlled rotating speed is 500r / min to obtain wet granules;

[0032] D, the wet granule that step c obtains is dried by vibrating fluidized bed, obtains bacitracin zinc premix 19Kg;

[0033] e, inspection: according to the inspection method inspection o...

Embodiment 2

[0036] a, after the fermented liquid is put into the tank, measure the fermented liquid volume 120L, the total unit of bacitracin is 0.096 billion, add zinc sulfate 0.96Kg according to the ratio of 10Kg / billion units, add 2% flavoring agent, 5% flocculant and auxiliary material simultaneously, After stirring for 2 hours, let it stand for 3 hours to obtain a mixed solution;

[0037] B, filter the mixed solution obtained in step a with a diaphragm plate and frame filter press, control the filtration pressure to 1.2MPa, filter for 8 hours, and remove the filter cake after the filtration is completed;

[0038] c, the filter cake obtained in step b is granulated through a rotating mixing granulator with a screen aperture of 1.2mm, and the controlled speed is 700r / min to obtain wet granules;

[0039] d, the wet granules obtained in step c are dried by a vibrating fluidized bed to obtain 22.8Kg of bacitracin zinc premix;

[0040] e, inspection: according to the inspection method ins...

Embodiment 3

[0043] a. After the fermented liquid is put into the tank, measure the fermented liquid volume to 150L, ​​the total unit of bacitracin is 0.12 billion, add 0.96Kg of zinc sulfate according to the ratio of 8Kg / billion units, add 1% flavoring agent, 2% flocculant and auxiliary materials simultaneously, After stirring for 0.5h, let it stand for 2h to obtain a mixed solution;

[0044] B, filter the mixed solution obtained in step a with a diaphragm plate and frame filter press, control the filtration pressure to 1MPa, filter for 6 hours, and remove the filter cake after the filtration is completed;

[0045] c, the filter cake obtained in step b is granulated through a rotating mixing granulator with a screen aperture of 0.8mm, and the controlled speed is 600r / min to obtain wet granules;

[0046] d, the wet granules obtained in step c are dried by a vibrating fluidized bed to obtain 28.5Kg of bacitracin zinc premix;

[0047] e, inspection: according to the inspection method inspec...

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Abstract

The invention relates to a preparation method of a bacitracin zinc premix. The preparation method comprises the following steps: a. arranging fermenting liquor into a tank, adding zinc sulfate, adding a flavor agent, a flocculating agent and excipients, stirring for 0.5-2h and standing for 1-3h to obtain a mixed solution; b. filtering the mixed solution obtained in the step a through a diaphragm plate-and-frame filter press, and taking down a filter cake after the filtering is completed; c. granulating the filter cake obtained in the step b, through a rotating mixed granulator to obtain wet granules; d. drying the wet granules obtained in the step c through a vibrating fluidized bed to obtain bacitracin zinc; e. checking; and f. performing finished product packaging. According to the preparation technology of the bacitracin zinc premix, the drying energy consumption is reduced, no odors exists, the product granules are uniform, the mobility is good, the flavor is easily accepted, the operation is convenient and the preparation method is suitable for large-scale production.

Description

technical field [0001] The invention specifically relates to a preparation method of a bacitracin zinc premix. Background technique [0002] Bacitracin (zinc) is off-white to light yellow powder; odorless, bitter in taste; hygroscopic; easily destroyed by oxidants, and can be precipitated by various heavy metal salts in solution without inactivation. Soluble in water, soluble in ethanol, insoluble in acetone, chloroform or ether. Bacitracin is unstable in strong acid and alkali, and zinc can improve the stability of bacitracin and enhance the antibacterial activity of bacitracin. Bacitracin zinc feed additive does not remain in animals, does not produce drug resistance, and is not easy to produce cross-resistance with other drugs. It is suitable for various poultry such as pigs, cattle, and chickens. Peptide (zinc) is "a large amount can cure diseases, a small amount can prevent diseases, and no diseases can promote growth". It is an antibiotic feed additive widely used in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/16A61K38/12A61K33/30
Inventor 常国栋曹建全安会波
Owner HEBEI SHENGXUE DACHENG PHARMA
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