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Nano-composite material applied to photodynamics therapy and preparation method thereof

A nano-composite material, photodynamic therapy technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, wave energy or particle radiation treatment materials, etc. restrictions, etc.

Inactive Publication Date: 2015-05-20
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main problems of photodynamic therapy (PDT) are that most photosensitizers are hydrophobic and have poor solubility in physiological environments, so they are prone to severe agglomeration, which will reduce their photosensitization efficiency and limit Their application in photodynamic therapy (PDT); the second is that UV-visible light is needed to irradiate tissue parts to excite photosensitizer molecules during treatment, while UV-visible light has limited penetration depth to tissues and can only be used in very shallow epidermis and treatment of parts that photons can reach
CNKI Central South University doctoral dissertation titled "The Effect and Mechanism of Hollow Silicon Nanoparticle Photosensitizer in Photodynamic Therapy of Cholangiocarcinoma", introduced a one-step wet chemical method to prepare loaded hollow silicon oxide nanoparticles, and realized the photosensitizer However, they are prone to severe agglomeration, which will reduce their photosensitization efficiency and limit their application in photodynamic therapy.

Method used

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  • Nano-composite material applied to photodynamics therapy and preparation method thereof
  • Nano-composite material applied to photodynamics therapy and preparation method thereof
  • Nano-composite material applied to photodynamics therapy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of NaGdF by high temperature pyrolysis 4 : 20%Yb / 1%Er (UCNPs): Weigh 0.4378g gadolinium oleate, 0.1124g ytterbium oleate, 0.0051g erbium oleate and 0.1050g sodium fluoride in a container, add 7.5ml octadecene and 7.5 ml of oleic acid, heated to 110°C under stirring and vacuuming. When no more bubbles were generated, turn off the vacuum device and keep it for 0.5h with nitrogen gas; Down to room temperature; the prepared nanoparticles are preserved in cyclohexane liquid after washing;

[0032](2) Synthesis of nanoparticles with core-shell structure: UCNPs were prepared by continuous coating method, and the cyclohexane liquid, 5ml oleic acid, and 5ml octadecene in step (1) were put in a container, and stirred and vacuumized The temperature was raised to 120°C, and when there were no more bubbles, the vacuum device was turned off, nitrogen gas was kept for 1 hour, and the mixture was heated to 310°C. At the same time weigh 0.10875g gadolinium trifluoroace...

Embodiment 2

[0038] (1) Preparation of NaGdF by high temperature pyrolysis 4 : 20%Yb / 1%Er (UCNPs): Weigh 0.4378g gadolinium oleate, 0.1124g ytterbium oleate, 0.0051g erbium oleate and 0.1050g sodium fluoride in a container, add 7.5ml octadecene and 7.5 ml of oleic acid, heated to 100°C under stirring and vacuuming. When no more bubbles were generated, turn off the vacuum device and keep for 1 h with nitrogen gas; room temperature; the prepared nanoparticles are preserved in cyclohexane liquid after washing;

[0039] (2) Synthesis of nanoparticles with core-shell structure: adopt continuous coating method to prepare UCNPs, take cyclohexane liquid, 5ml oleic acid, and 5ml octadecene in a container, stir and vacuumize Raise the temperature to 110°C, and when there are no more bubbles, close the vacuum device, keep it flowing with nitrogen for 0.5h, and heat to 320°C. At the same time weigh 0.10875g gadolinium trifluoroacetate (Gd(CF 3 COO) 3 ), 0.0128g ytterbium trifluoroacetate (Yb(CF 3...

Embodiment 3

[0044] (1) Preparation of NaGdF by high temperature pyrolysis 4 : 20%Yb / 1%Er (UCNPs): Weigh 0.4378g gadolinium oleate, 0.1124g ytterbium oleate, 0.0051g erbium oleate and 0.1050g sodium fluoride in a container, add 7.5ml octadecene and 7.5 ml of oleic acid, heated to 105°C under stirring and vacuuming. When no more bubbles were generated, turn off the vacuum device and keep it for 1h with nitrogen gas; to room temperature; the prepared nanoparticles are preserved in cyclohexane liquid after washing;

[0045] (2) Synthesis of nanoparticles with core-shell structure: adopt continuous coating method to prepare UCNPs, take cyclohexane liquid, 5ml oleic acid, and 5ml octadecene in a container, stir and vacuumize Raise the temperature to 115°C, and when there are no more bubbles, close the vacuum device, keep it under nitrogen for 1 hour, and heat to 315°C. Weigh 0.10875g gadolinium trifluoroacetate at the same time

[0046] (Gd(CF 3 COO) 3 ), 0.0128g ytterbium trifluoroacetate...

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Abstract

The invention provides a nano-composite material applied to photodynamics therapy and a preparation method thereof. The method comprises the following steps: (1) ensuring that rare-earth up-conversion materials are high-quality nano-particles which can be used for effectively transmitting near-infrared light to photosensitive medicine molecules; (2) controlling the thickness of mesoporous SiO2 according to the conditions such as the concentration of UCNPs, the quantity of hexadecyl trimethyl ammonium bromide and tetraethoxysilane and the reaction temperature and time; (3) modifying UCNPs @SiO2 by using Au25 to prepare the nano-particles to ensure that the photodynamic performance of the nano-particles can be obviously improved. A nano-carrier which is uniform, high in monodisperse property and controlled in sizes (50-100 nm) and of which the mesoporous SiO2 covers the up-conversion nano-particle core-shell structure is provided; moreover, through a proper adsorption method, a photosensitizer medicine molecule Au25 (Capt)18-(Au25) is bonded to a mesoporous SiO2 framework to build a multifunctional composite material, and the current problem of photodynamics therapy (PDT) can be solved by using the material.

Description

technical field [0001] The invention relates to a nanocomposite material, and also relates to a preparation method of the nanocomposite material. Specifically, it relates to a nanocomposite material used in photodynamic therapy and a preparation method thereof. Background technique [0002] Photodynamic therapy (PDT) is a new technology for diagnosis and treatment of diseases based on the interaction of light, photosensitizers and oxygen. excited state and transfers its energy to surrounding oxygen molecules, resulting in singlet oxygen ( 1 o 2 ) or free radicals and other reactive oxygen species (ROS), and thus cause tissue and organ damage to destroy the target tissue and achieve the purpose of treatment. Compared with traditional cancer treatment methods including surgery, chemotherapy, and radiation therapy, photodynamic therapy (PDT) has significant advantages such as less trauma, low toxicity, good selectivity, high precision, repeatable treatment, and collaborative...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/04A61P35/00
Inventor 杨飘萍贺飞于毓秀徐洁张强杨桂欣盖世丽
Owner HARBIN ENG UNIV