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A method for controlling the quality stability of the extraction process of traditional Chinese medicine formula granules

A technology of traditional Chinese medicine formula granules and quality stability, which is applied in the direction of non-electric variable control, control/regulation system, and simultaneous control of multiple variables. It can solve the problems of incomplete extraction of active ingredients, long extraction time, and uneven temperature. To achieve the effect of ensuring process and quality stability, high content of active ingredients, and overcoming unstable quality

Active Publication Date: 2017-05-24
ANHUI CHINA RESOURCES JINCHAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The extraction temperature affects the dissolution rate of the active ingredients. If the temperature is too low, the extraction of the active ingredients will be incomplete, resulting in unqualified final products; if the temperature is too high, it may cause the decomposition of heat-sensitive ingredients, and may even lead to the dissolution of the drug. The liquid is fried, which will eventually lead to unqualified products
However, most of the current Chinese medicine extraction tanks have the problem of uneven temperature in the tank, which leads to long extraction time, poor extraction effect, low heat exchange efficiency, high energy consumption, and even seriously affects the quality of the product.

Method used

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  • A method for controlling the quality stability of the extraction process of traditional Chinese medicine formula granules
  • A method for controlling the quality stability of the extraction process of traditional Chinese medicine formula granules
  • A method for controlling the quality stability of the extraction process of traditional Chinese medicine formula granules

Examples

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Effect test

Embodiment 1

[0025] Take 100 Kg of honeysuckle decoction pieces and add 800 Kg of water to soak for 30 minutes, heat to boil and keep boiling for 2 hours. Heating is carried out through the extraction tank double-layer jacket segmental heating and tank bottom heating technology. After heating for 15 minutes, the extract boils. Real-time monitoring of the temperature and pressure in the extraction tank, the steam flow rate and the temperature of the cooling water entering and leaving the condenser, the design temperature difference between the cooling water entering and exiting is 12~18°C, the temperature setting in the tank is 96~102°C, and the pressure is 0~0.02 MPa. Arrange 6 temperature probes in the tank, which are respectively distributed at the upper end, middle end and bottom of the extraction tank near the jacket and near the center line. Cooling water inlet and outlet temperature difference Δt and cooling water inlet and outlet speed v It has a certain functional relationship. W...

Embodiment 2

[0030] Take 100 Kg of Ligusticum chuanxiong and add 600 Kg of water to soak for 120 minutes, heat to boil and keep boiling for a few hours. The volatile oil of Rhizoma Chuanxiong is collected, and the oil-water interface detection technology is used for the oil-water separator to realize automatic oil-water separation. The oil-water interface detection technology can make the moisture content in the volatile oil lower than 3%. Get the obtained volatile oil and adopt gas chromatography to detect the moisture content in the volatile oil. The water content in the obtained volatile oil is shown in the table below.

[0031] Gas chromatography conditions: column: GDX101 column (3m × Φ4 mm); detector: thermal conductivity detector; injector temperature: 150 ~ 170 ℃; column temperature: 120 ~ 140 ℃; detector temperature: 140 ~160℃; carrier gas: helium; carrier gas flow: 40 ~ 50 mL / min.

[0032]

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Abstract

The invention discloses a method for controlling the quality stability of the extraction process of traditional Chinese medicine formula granules, which is controlled by segmental heating of the double-layer jacket of the extraction tank and the heating technology of the bottom of the tank; the collaborative control mode of temperature, pressure, cooling water flow and steam flow is adopted, and real-time Adjust steam input and cooling water flow to reduce temperature fluctuations in the extraction tank; oil-water interface detection technology is used in the oil-water separator to realize automatic oil-water separation. The invention is applied to the extraction process of traditional Chinese medicine formula granules, the heating rate is not lower than 4°C / min, the temperature fluctuation of the extraction tank during the extraction process is less than 3%, and the obtained extraction liquid has a high liquid output, high solid content, and effective component content High, the difference between batches is less than 5%, ensuring the process and quality stability of the extraction process, and overcoming the problem of unstable quality in the existing extraction process.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a method for controlling the quality stability of the extraction process of traditional Chinese medicine formula granules. Background technique [0002] The pharmaceutical process of traditional Chinese medicine formula granules generally includes: pretreatment of medicinal materials (harvesting-washing-drying)-extraction-separation-purification-(crushing)-screening analysis-mixing-granulation. The extraction process is an important link in the production of traditional Chinese medicine formula granules, and plays a vital role in the safety, effectiveness, and stability of the final product. Extraction is the process of dissolving the active ingredients in traditional Chinese medicine from plant tissues with an appropriate solvent. The extraction temperature affects the dissolution rate of the active ingredients. If the temperature is too low, the extraction ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G05D27/02B01D11/02
Inventor 高波罗川
Owner ANHUI CHINA RESOURCES JINCHAN PHARMA CO LTD