Novel rebamipide prodrug, method for producing same, and usage thereof

Abstract

Disclosed are a novel rebamipide prodrug, a method for preparing the same, and use thereof. Also, a pharmaceutical composition comprising the novel rebamipide prodrug as an active ingredient is provided. The rebamipide prodrug is increased 25-fold in absorption rate compared to rebamipide itself, and can be applied to the prophylaxis or therapy of gastric ulcer, acute gastritis, chronic gastritis, xerophthalmia, cancer, osteoarthritis, rheumatoid arthritis, or obesity.

Description

technical field

[0001] The present invention relates to novel rebamipide prodrug, its preparation method and use. More specifically, the present invention relates to a novel prodrug of rebamipide which maintains the same efficacy as rebamipide but has improved bioavailability, and a method for preparing the prodrug, which is a simple method. Background technique

[0002] Rebamipide (system name 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolon-4-yl]propionic acid) is a drug used for peptic ulcer (including gastric ulcer, Excellent therapeutic agent for acute gastritis and gastric mucosal lesions caused by acute exacerbation of chronic gastritis). The drug exerts a gastroprotective function by stimulating the biosynthesis of PGE2 in the gastric mucosa and by promoting the proliferation of endothelial cells. In particular, the drug is prescribed to patients suffering from gastritis caused by Helicobacter pyroli because it prevents bacteria from adhering to and infiltrating gastric ...

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