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A kind of starch-based vegetable hollow capsule

A plant hollow capsule, starch-based technology, which is applied in the directions of capsule delivery, food science, medical preparations with inactive ingredients, etc., can solve the problems of poor moisture retention of starch films, difficult to achieve industrialization, difficult to obtain strength, etc. The effect of starch retrogradation, improving mechanical properties and improving appearance

Active Publication Date: 2017-04-26
湖南素囊健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since strong hydrogen bonds are easily formed between starch molecules, the starch film has poor moisture retention, is brittle and brittle, and it is difficult to produce high-strength, filling-resistant capsules.
Therefore, although there are many patents, it is difficult to realize industrialization and form products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] After mixing 50 parts of hydroxypropyl starch, 10 parts of ordinary starch, 10 parts of water and 1 part of curing system (containing 97wt% carrageenan, 3wt% sodium citrate) as the base, the conventional capsules are prepared The process of preparing hard capsules.

[0043] The hard capsules prepared above were referenced to the method specified in Part Two of the Chinese Pharmacopoeia 2010, and the friability was detected by the PTFE method code. 50 samples were broken into 0, and the friability could meet the requirements of the Pharmacopoeia.

[0044] Using the NPJ-2500 automatic capsule filling machine to test the hard capsules prepared above, the loading rate reached over 99.99%.

Embodiment 2

[0046] After mixing 50 parts of hydroxyethyl starch, 10 parts of ordinary starch, 5 parts of water and 10 parts of curing system (containing 99wt% gellan gum and gum arabic, 1wt% sodium phosphate) as the base, use Hard capsules are prepared by conventional capsule preparation technology.

[0047] The hard capsule prepared above was referenced to the method specified in Part Two of the Chinese Pharmacopoeia 2010 edition, and the friability of 50 samples was tested by using the PTFE method. The friability of 50 samples was broken into one, and its friability could meet the requirements of the Pharmacopoeia.

[0048] Using the NPJ-2500 automatic capsule filling machine to test the hard capsules prepared above, the loading rate reached over 99.99%.

Embodiment 3

[0050] Mix 60 parts of carboxymethyl hydroxypropyl starch as base, 20 parts of ordinary starch, 10 parts of water and 5 parts of curing system (containing 98wt% gum arabic and mannan, 2wt% sodium tartrate) Afterwards, hard capsules were prepared using conventional capsule preparation techniques.

[0051] The hard capsules prepared above were referenced to the method specified in Part Two of the Chinese Pharmacopoeia 2010, and the friability was detected by the PTFE method code. 50 samples were broken into 0, and the friability could meet the requirements of the Pharmacopoeia.

[0052] Using the NPJ-2500 automatic capsule filling machine to test the hard capsules prepared above, the loading rate reached over 99.99%.

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Abstract

The invention discloses starch-based plant empty capsule which is applied to the fields of food, medicine and the like. The starch-based plant empty capsule mainly comprises starch, starch derivatives, water, a curing system and other various selectable auxiliary materials such as a moisturizer, a plasticizer and the like; the starch-based plant empty capsule can be prepared with a conventional capsule preparation process. Compared with a product in the prior art, the starch-based plant empty capsule has the advantages of high safety, excellent friability, good moisture retention and stability and convenience in storage and placement.

Description

Technical field [0001] The invention relates to a starch-based plant hollow capsule used in the fields of food, medicine and the like. Background technique [0002] The use of animal-derived gelatin to make capsules has a history of nearly 200 years. In the past 100 years, various capsules made of gelatin have been sold well in the international pharmaceutical market for a long time. At the end of the last century, the outbreak of mad cow disease finally dragged gelatin capsules into an unprecedented crisis of confidence. And the "poison capsule" incident that broke out in my country in April 2012 undoubtedly aggravated the crisis of confidence in gelatin capsules. In addition, gelatin capsules themselves have many shortcomings, such as: easy to breed microorganisms, fragile, high environmental humidity is prone to adhesion with drugs, while low environmental humidity is less flexible and fragile; in addition, gelatin molecular chain contains a lot of active The group may have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A23P10/30
Inventor 帅放文王向峰章家伟
Owner 湖南素囊健康科技有限公司
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