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Albendazole suspension and preparation method thereof

A technology of albendazole and suspension, which is applied in the field of pharmaceutical preparations, can solve the problems of fetal absorption and bone deformity, low solubility of albendazole, low bioavailability, etc., and achieves improved bioavailability and simple preparation process Feasible, good redispersibility effect

Inactive Publication Date: 2015-06-10
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has no effect on the reproductive function of male mice, and has no teratogenic effect on female mice, but for female rats and rabbits, fetal resorption and skeletal deformities may occur when a large dose (30mg / kg / day) is applied and other phenomena
[0005] At present, due to the low solubility of albendazole in water, the commonly used dosage forms are mainly tablets and capsules. In actual production, there are often defects in feeding difficulties and low bioavailability, which greatly limits the clinical application of this drug.

Method used

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  • Albendazole suspension and preparation method thereof
  • Albendazole suspension and preparation method thereof
  • Albendazole suspension and preparation method thereof

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preparation example Construction

[0025] The step of the preparation method of described a kind of albendazole suspension is:

[0026] 1) Prescription screening: Carboxymethylcellulose sodium was determined as suspending agent, polysorbate-80 as wetting agent, citric acid as flocculant, and sodium benzoate as antioxidant through single factor test; then L16 (4 5 ) Orthogonal method is designed to screen the concentration of sodium carboxymethylcellulose, polysorbate-80, citric acid and sodium benzoate, and the physical properties of the suspension, sedimentation volume ratio, redispersibility, and drug content Using the chemical characteristics as an index, compare the stability of each prescription to determine the best prescription;

[0027] 2) Preparation: adopt the dispersion method, prepare the suspension with a high-speed homogeneous disperser, the steps are as follows:

[0028] a. Dissolve the suspending agent, flocculant and antioxidant in distilled water, and wait for swelling or dissolving for later...

Embodiment 1

[0043] A kind of albendazole suspension, prescription consists of:

[0044] 0.25g albendazole, 0.025g sodium carboxymethylcellulose, 0.0125mL polysorbate-80, 0.125g citric acid, 0.005g sodium benzoate, purified water to 25mL.

[0045] Its preparation method is:

[0046] (1) Dissolve the suspending agent, wetting agent, flocculant, and antioxidant in an appropriate amount of distilled water, and wait for swelling or dissolving for later use;

[0047] (2) Dissolve the wetting agent in a small amount of distilled water, then add albendazole for wetting, mix with a high-speed homogeneous disperser, transfer to a 25mL graduated cylinder, use a distilled water homogenizer several times, and transfer to the graduated cylinder;

[0048](3) Add distilled water to make up to 25mL, seal the mouth of the cylinder, mix well, and get ready.

Embodiment 2

[0050] A kind of albendazole suspension, prescription consists of:

[0051] 0.25g albendazole, 0.125g sodium carboxymethylcellulose, 0.25mL polysorbate-80, 0.2g citric acid, 0.075g sodium benzoate, purified water to 25mL.

[0052] Its preparation method is with embodiment 1.

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Abstract

The invention discloses an albendazole suspension. The albendazole suspension is composed of the following raw materials in parts by weight: 1.75g of albendazole, 0.3g of sodium carboxymethylcellulose, 0.0125mL of polysorbate-80, 0.3g of citric acid, 0.075g of sodium benzoate and purified water is added until the whole weight is 25mL. By adopting the albendazole suspension disclosed by the invention, albendazole medicine is more convenient to use, meanwhile the anthelmintic effect is greatly improved and the administration times is reduced.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to an albendazole suspension and a preparation method thereof. Background technique [0002] Parasitic diseases seriously threaten the health of animals and seriously restrict the development of animal husbandry. It is of great practical significance to develop high-efficiency and low-toxic anthelmintic drugs. Albendazole, also known as albendazole, is a benzimidazole derivative. It is widely used in the prevention and treatment of humans and animals due to its broad spectrum of insect resistance, low price, low toxicity and high efficiency. Various parasitic diseases, such as ascariasis and tapeworm, are also used to treat strongyloidiasis. Albendazole is considered to be one of the most effective anthelmintics among benzimidazoles. [0003] After albendazole is catabolized into sulfoxides or sulfones in animals, these metabolites inhibit the absorption of gl...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/4184A61P33/00A61K47/38
Inventor 李引乾党丽梅袁富威叶文初班赟冶冬阳
Owner NORTHWEST A & F UNIV
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