Microneedle patch convenient for administrating animal vaccine and preparation method of microneedle patch

A microneedle patch and vaccine technology, applied to microneedles, medical devices, needles, etc., can solve problems such as injection inconvenience, skin and muscle damage, and low efficiency, and achieve simple and economical production methods, avoid cross-infection, and facilitate operation Effect

Active Publication Date: 2015-06-17
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When injecting vaccines by traditional injection methods, there will be many problems: the pain caused by the injection will cause the animal's fear reaction, which will cause inconvenient injection; the skin and muscle damage or skin infection will be caused during the injection; the needle will break during the injection; there will be crossover. The possibility of infection; in order to avoid cross-infection needles need to be replaced, and the biological waste brought by disposable sy...

Method used

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  • Microneedle patch convenient for administrating animal vaccine and preparation method of microneedle patch
  • Microneedle patch convenient for administrating animal vaccine and preparation method of microneedle patch
  • Microneedle patch convenient for administrating animal vaccine and preparation method of microneedle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A microneedle patch that facilitates the administration of animal vaccines, the microneedle patch includes a soluble microneedle base and a soluble microneedle body; the soluble microneedle body is loaded with a target drug, and its preparation material includes a water-soluble A biodegradable polymer material; the polymer material is polyvinyl alcohol with a weight average molecular weight of 2000-300000; the preparation material also includes a stabilizer, which is sucrose; the drug loading method of the target drug is The tip is loaded with medicine; the microneedle patch is a square with a side length of 10 mm, and there are 100 microneedles in total, and the distance between adjacent microneedles is 0.5 mm; the shape of the microneedle body is conical or cone-like shape, the length of the microneedle body is 700 μm, and the bottom diameter is 500 μm.

[0019] A kind of preparation method of the microneedle patch that is convenient to animal vaccine administration a...

Embodiment 2

[0022] A microneedle patch that facilitates the administration of animal vaccines, the microneedle patch includes a soluble microneedle base and a soluble microneedle body; the soluble microneedle body is loaded with a target drug, and its preparation material includes a water-soluble A biodegradable polymer material; the polymer material is polyvinyl alcohol with a weight-average molecular weight of 2000-300000; the preparation material also includes a stabilizer, which is rubrumone terpene; the loading of the target drug The way of medicine is drug loading on the tip; the microneedle patch is a square with a side length of 10mm, and there are 100 microneedles in total, and the distance between adjacent microneedles is 0.7mm; the shape of the microneedle body is conical Or conical shape, the length of the microneedle body is 700 μm, and the bottom diameter is 500 μm.

[0023] A method for preparing a microneedle patch that is convenient for animal vaccine administration accor...

Embodiment 3

[0026] A microneedle patch that facilitates the administration of animal vaccines, the microneedle patch includes a soluble microneedle base and a soluble microneedle body; the soluble microneedle body is loaded with a target drug, and its preparation material includes a water-soluble A biodegradable polymer material; the polymer material is polyvinyl alcohol with a weight average molecular weight of 2000-300000; the preparation material also includes a stabilizer, which is trehalose; the drug loading method of the target drug The tip is loaded with medicine; the microneedle patch is a square with a side length of 10 mm, and there are 100 microneedles in total, and the distance between adjacent microneedles is 0.6 mm; the shape of the microneedle body is conical or similar Conical shape, the length of the microneedle body is 600 μm, and the bottom diameter is 500 μm.

[0027] A preparation method of a microneedle patch that is convenient for animal vaccine administration accor...

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Abstract

The invention belongs to the technical field of administration equipment and particularly relates to a microneedle patch convenient for administrating animal vaccine and a preparation method of the microneedle patch. The microneedle patch comprises a soluble patch substrate and soluble microneedle bodies in array distribution on the patch substrate, wherein the microneedle bodies carry a targeted medicine at the top ends. The preparation material of the microneedle bodies comprises a water soluble degradable macromolecular material. Compared with the prior art, the microneedle patch convenient for administrating animal vaccine provided by the invention does not cause fear responses of animals when a vaccine is inoculated, is easy to administrate and convenient to operate, and inoculating personnel needs not to be trained; the vaccine inoculating work can be completed by a single person, so that the efficiency is high; the animal is not marked in an extra manner when the vaccine is inoculated; the microneedle patch is used at one time, so that the probability of cross infection is avoided; the material used is biodegradable and free of medical wastes; the microneedle patch is simple and economic in preparation method, free of cold preservation or vacuum storage and the like and convenient to transport.

Description

technical field [0001] The invention belongs to the technical field of drug delivery equipment, and in particular relates to a microneedle patch which is convenient for animal vaccine drug delivery and a preparation method thereof. Background technique [0002] Vaccines are an important weapon to control an infectious disease. Animal vaccines belong to the category of veterinary biological products. Veterinary biological products are a class of substances prepared from microorganisms, parasites and their metabolites or immune response products based on the principles of immunology. Such substances are intended exclusively for the diagnosis, treatment or prevention of corresponding diseases in animals. The invention and promotion of animal vaccines can prevent and control the occurrence and prevalence of animal infectious diseases, and have made great contributions to the healthy development of animal husbandry in my country. [0003] The traditional method of administratio...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61M37/00A61K39/12A61P31/14
CPCA61M37/0015A61M2037/0046A61M2037/0053
Inventor 郭新东王淇磊陈洋
Owner BEIJING UNIV OF CHEM TECH
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