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Traditional Chinese medicine composition for treating diabetic nephropathy and application thereof

A technology of diabetic nephropathy and composition, which is applied in the field of traditional Chinese medicine composition for the treatment of diabetic nephropathy, and can solve problems such as the pathology and pathogenesis of diabetic nephropathy that cannot be fully understood

Active Publication Date: 2015-06-24
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these two traditional Chinese medicines are mainly used to treat chronic nephritis, not for diabetic nephropathy, and at the same time, they cannot fully understand the pathology and pathogenesis of diabetic nephropathy

Method used

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  • Traditional Chinese medicine composition for treating diabetic nephropathy and application thereof
  • Traditional Chinese medicine composition for treating diabetic nephropathy and application thereof
  • Traditional Chinese medicine composition for treating diabetic nephropathy and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0053] Experimental example: Therapeutic effects of a pair of surgery + high fat + STZ induced diabetic nephropathy model rats

[0054] experiment material

[0055] 1. Test drug

[0056] Take the following raw materials in weight ratio: 100 parts by weight of Astragalus, 33.3 parts by weight of Ligustrum lucidum, 33.3 parts by weight of Atractylodes macrocephala, 50 parts by weight of Fructus Rosa, 50 parts by weight of hollyhock flower, 40 parts by weight of Mian scorpion, 40 parts by weight of Radix Paeoniae Rubra , 20 parts by weight of Coptidis rhizome, prepared by the preferred process in the second preferred embodiment of the preparation method of the traditional Chinese medicine composition of the present invention part of the summary of the invention to obtain the traditional Chinese medicine composition of the present invention, 6.67g crude drug / g ointment powder, batch number: 20140411, Provided by the Institute of Chinese Materia Medica, China Academy of Chinese Me...

experiment example 2

[0128] Experimental Example 2 Therapeutic Effects on Doxorubicin-Induced Nephropathy Rat Model

[0129] One of the most important early manifestations of diabetic nephropathy is a significant increase in urinary protein, while common nephropathy has the same manifestation. Therefore, this experimental example adopts a common nephropathy rat model to evaluate the effect of the traditional Chinese medicine composition obtained by the two preferred preparation methods of the present invention on urinary protein.

[0130] experiment material

[0131] 1. Test drug The traditional Chinese medicine composition of this application:

[0132] Take the following raw materials in weight ratio: 100 parts by weight of Astragalus, 33.3 parts by weight of Ligustrum lucidum, 33.3 parts by weight of Atractylodes macrocephala, 50 parts by weight of Fructus Rosa, 50 parts by weight of hollyhock flower, 40 parts by weight of Mian scorpion, 40 parts by weight of Radix Paeoniae Rubra , 20 parts by...

Embodiment 1

[0179] Get 100 parts by weight of raw Radix Astragali, 33.3 parts by weight of Ligustrum lucidum, 40 parts by weight of Atractylodes macrocephala, 50 parts by weight of Fructus Rosa, 50 parts by weight of hollyhock flower, 40 parts by weight of Mianzi, 50 parts by weight of Radix Paeoniae Rubra, 20 parts by weight of Coptis chinensis, add water Extract 2 times, adding 10 times the amount of water and 10 times the total weight of the medicinal materials each time, each extraction time is 1 hour, combine the extracts, concentrate to a relative density of about 1.15, and add ethanol to make the alcohol content 80vol% , mix well, stand for 12 hours, take the supernatant, recover ethanol until it has no alcohol taste, add water and correctives, and make an oral liquid.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating diabetic nephropathy. The traditional Chinese medicine composition comprises the following active ingredients in parts by weight: 100 parts of astragalus membranaceus, 20-40 parts of glossy privet fruit, 25-45 parts of white atractylodes rhizome, 40-60 parts of fructus rosae laevigatae, 40-60 parts of abelmoschus manihot, 30-50 parts of dioscorea spongiosa, 35-55 parts of root of common peony and 15-35 parts of goldthread. The invention also discloses a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention has good therapeutical effect on the diabetic nephropathy and particularly on the early-stage diabetic nephropathy.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating diabetic nephropathy and its application. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN) is one of the main complications of diabetes. Abnormal glucose metabolism causes absolute and relative insufficiency of insulin in the body, resulting in disturbance of glucose, protein and fat metabolism. Characterized by loss of renal function. Diabetic nephropathy is one of the main causes of chronic renal failure, and its occurrence will reduce the quality of life of patients, increase the mortality of diabetic patients, and also increase the disease burden of the health care system. Diabetic nephropathy occurs in about 50% of patients with diabetes for more than 10 years. About 33.6% of hospitalized diabetic patients with kidney disease in my country. Currently, 15% to 25% of type 1 diabetes patients and 30% to 40% of type 2 diabetes patients have...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P3/10A61P13/12
Inventor 刘建勋任钧国洪晓华王杨慧姚明江
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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