A kind of fermented astragalus compound preparation and its preparation method and application

A compound preparation, the technology of astragalus, applied in the direction of application, drug combination, medical formula, etc., to achieve the effect of improving immunity and anti-stress ability, inhibiting the growth of harmful bacteria, and shortening the recovery period

Active Publication Date: 2018-11-30
山东宝来利来生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the actual breeding process, there is often immunosuppression, which cannot be relieved by a single vaccine or chemical drug control, and the European Union's 1999 legislative inscription prohibits the use of flavomycin, avelamycin, monensin and All antibacterial and anticoccidial feed additives except bacillus clear, therefore, finding a new type of safe, pollution-free, green feed additive to improve animal immunity is a hot and difficult point at present

Method used

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  • A kind of fermented astragalus compound preparation and its preparation method and application
  • A kind of fermented astragalus compound preparation and its preparation method and application
  • A kind of fermented astragalus compound preparation and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0040] Embodiment 1: Condition optimization of fermented Astragalus membranaceus

[0041] 1 test material

[0042] 1.1 Traditional Chinese Medicine: Astragalus, Banlangen, and Echinacea, purchased from Longtan Pharmacy in Tai’an City, Shandong Province.

[0043]1.2 Tested strain: Bacillus subtilis B7348 (Bacillus subtilis B7348), which was deposited in the China Center for Type Culture Collection on October 12, 2010, and its preservation number is CCTCC M 2010260; it is recorded in another patent of the applicant " A strain of Bacillus subtilis with strong antibacterial effect and its application" (CN 102120975 B). Bacillus subtilis N9-1-35 (Bacillus subtilis N9-1-35), has been preserved in China Center for Type Culture Collection on August 31, 2011, and its preservation number is CCTCC M 2011301; it is recorded in another A patent "A Bacillus subtilis bred by aerospace breeding technology and its application" (CN 102329749B).

[0044] 1.3 Medium Bacillus liquid medium: glu...

Embodiment 2

[0074] Embodiment 2: the preparation of fermented astragalus compound preparation

[0075] 1. Formulation:

[0076] 250 grams of fermented astragalus powder, 25 grams of Radix Radix, 20 grams of Echinacea, 5 grams of vitamin C, 100 grams of yeast selenium, 50 grams of zymosan, and 550 grams of Fumei powder.

[0077] Astragalus, Radix Isatidis, and Echinacea were purchased from Longtan Pharmacy in Tai'an City, Shandong Province; vitamin C, yeast selenium, zymosan, and Fumei powder were commercially available products.

[0078] 2. Preparation method:

[0079] (1) Preparation of Fermented Astragalus Powder:

[0080] Inoculate Bacillus subtilis B7348 and Bacillus subtilis N9-1-35 on the bacillus slant respectively, then pick a little into a 100mL Erlenmeyer flask with an inoculation loop, place it on a shaking table at 37°C and 220rpm, and culture it with shaking for 24h; after that Inoculate the bacterial liquids of Bacillus subtilis B7348 and Bacillus subtilis N9-1-35 in the ...

Embodiment 3

[0085] Embodiment 3: the preparation of fermented Astragalus compound preparation

[0086] 1. Recipe: 200 grams of fermented astragalus powder, 30 grams of Banlangen, 15 grams of Echinacea purpurea, 8 grams of vitamin C, 80 grams of yeast selenium, 60 grams of zymosan, and 500 grams of Fumei powder.

[0087] 2. Preparation method: with embodiment 2.

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Abstract

The invention discloses a fermented astragalus compound preparation, which is prepared from the following raw materials in parts by weight: 200-300 parts of fermented astragalus powder, 20-30 parts of Radix Radix, 15-25 parts of Echinacea purpurea, 3-8 parts of vitamin C, and 80 parts of yeast selenium 120 parts, 40-60 parts of zymosan, 500-600 parts of fumei powder; the fermented astragalus powder is mixed fermentation culture of Bacillus subtilis B7348 and Bacillus subtilis N9-1-35 in aqueous solution of astragalus, and the fermentation product is frozen Prepared dry. The invention also discloses a preparation method of the fermented astragalus compound preparation. The fermented astragalus compound preparation of the present invention can fully activate the autoimmune mechanism of animals, improve immunity and anti-stress ability, shorten the recovery period of sick animals, reduce the death rate of animals, improve animal production performance, and is green, safe, efficient, and non-toxic. toxic side effect.

Description

technical field [0001] The invention relates to a fermented astragalus compound preparation, a preparation method and application thereof. Background technique [0002] Astragalus is an important medicinal material in traditional Chinese medicine, which was first recorded in "Shen Nong Baicao Jing". "Chinese Pharmacopoeia" (2010 Edition) stipulates that medicinal Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Astragalus membrane pod Astragalus membranaceus (Fisch.) Bge. [0003] Astragalus polysaccharide is one of the effective components of Astragalus, which has immune regulation effect, can improve the immune response ability to antigen and the conversion rate of lymphocytes, and enhance the phagocytic ability of macrophages. However, the extraction rate of astragalus polysaccharides is relatively low in the existing processing methods of Astragalus membranaceus, which has become a technical bottleneck restricting the further application of Astragalu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61P37/04A23K20/10A61K31/375A61K31/715
Inventor 单宝龙陈雷谷巍孙合美张建梅王红廉新慧秦波谢全喜张文王春凤
Owner 山东宝来利来生物工程股份有限公司
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