Microneedle template and preparation method thereof

A microneedle and template technology, applied in the directions of microneedles, needles, manufacturing tools, etc., can solve the problems of low preparation efficiency, complicated operation process, affecting the sharpness of the tip of the pinhole, etc., to achieve a simple and easy method, and the template is tough and durable. , good uniformity

Inactive Publication Date: 2015-08-19
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, silicon chip microneedle molds are processed and prepared by microelectronic system processing method and chemical etching method. The former has a complicated operation process, and the latter is difficult to prepare microneedles with sharp tips; materials such as gypsum and purple sand need to be used to prepare microneedle molds. It is difficult to ensure the uniformity of the pinhole and the sharpness of the tip when the hole-forming tool is used for piercing; in addition, the microneedle template made of hard materials is not suitable for the preparation of soluble drug-loaded microneedles
The current preparation method of polydimethylsiloxane microneedle mold is to first use chemical etching method, photolithography method, laser cutting method, etc. to prepare solid microneedle with silicon material or metal material, and then use the formed microneedle mold Preparation of polydimethylsiloxane inversion mold, the disadvantage of this technology is that it must be prepared with a solid microneedle mold first, which affects the sharpness of the pinhole tip and the preparation efficiency is low

Method used

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  • Microneedle template and preparation method thereof
  • Microneedle template and preparation method thereof
  • Microneedle template and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Preparation of microneedle templates with a height of 600 μm, a bottom diameter of 300 μm, a pitch of 0.5 mm, and a 10×10 array. The steps are as follows: 1) Preparation of polydimethylsiloxane film: weigh 150g of polydimethylsiloxane and 15g of aminoethylpiperazine curing agent to mix, stir evenly, remove air bubbles under vacuum conditions, and transfer to the bottom surface Put it in a smooth and flat container with a size of 40cm×20cm, place it horizontally, and cure it at 60°C for 6 hours to obtain a polydimethylsiloxane film with a thickness of 1.5mm and an area of ​​40cm×20cm as a template blank film, and package it for use; 2 ) Laser engraving: Cut the above-mentioned template blank film into a strip film with a width of 2cm and a length of 25cm, and put it into the laser engraving machine; turn on the laser engraving machine, and import a row of 12 red dot matrix with a distance of 150mm. The number of dots is 10×10, the distance between dots is 0.5mm, and the ...

Embodiment 2

[0027] Preparation of a microneedle template with a height of 400 μm, a bottom diameter of 200 μm, a microneedle spacing of 0.5 mm, and a 20×20 array. The steps are as follows: 1) Preparation of polydimethylsiloxane film: weigh 150g polydimethylsiloxane and 15g aminoethylpiperazine curing agent (this curing agent has added 1% dihydroconiferous cypress After adding base alcohol γ-O-α-L-rhamnoside, compared with no addition, its elasticity is improved and the service life is extended by 35%), mix well, remove air bubbles under vacuum conditions after stirring, and transfer to the bottom surface smooth and flat , in a container with a size of 40cm×20cm, placed horizontally, and cured at 60°C for 6 hours to obtain a polydimethylsiloxane film with a thickness of 1.5mm and an area of ​​40cm×20cm as a template blank film, which is packaged for use; 2) the Cut the above-mentioned polydimethylsiloxane film into a strip film with a width of 2 cm and a length of 25 cm, and put it into a ...

Embodiment 3

[0029] Preparation of a microneedle template with a height of 1000 μm, a bottom diameter of 280 μm, a microneedle spacing of 0.8 mm, and a 5×5 array.

[0030] The steps are as follows: 1) Preparation of polydimethylsiloxane film: Weigh 150g of polydimethylsiloxane and 15g of diaminodiphenyl sulfone curing agent to mix, stir evenly, remove air bubbles under vacuum conditions, transfer to the end Put it in a container with a smooth surface and a size of 40cm×20cm, place it horizontally, and cure it at 60°C for 6 hours to obtain a polydimethylsiloxane film with a thickness of 1.5mm and an area of ​​40cm×20cm as a template blank film, and package it for use; 2) Cut the above-mentioned polydimethylsiloxane film into a strip film with a width of 2 cm and a length of 25 cm, and put it into a laser engraving machine; turn on the laser engraving machine, and import a row of 12 red dots with a distance of 150 mm. The number of lattice points is 20 × 20, the point spacing is 0.8mm, the r...

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Abstract

The invention belongs to the technical field of dosing equipment and specifically relates to a microneedle template and a preparation method thereof. The microneedle template is prepared from a polydimethylsiloxane film; a micropore array is formed in the surface of the polydimethylsiloxane film; and the polydimethylsiloxane film is prepared by mixing a polydimethylsiloxane film prepolymer and a curing agent. Compared with the prior art, the microneedle template is excellent in micropore uniformity; the template is firm and durable, and applicable to preparing microneedle products of a plurality of types by use of a melt or solution pouring method; and as being proven, the prepared microneedles can be applied to transdermal drug delivery or skin preprocessing. In addition, the preparation method only comprises directly perforating the surface of the polydimethylsiloxane only by use of a laser beam; the preparation material is simple, the method is simple and easy to implement, the preparation efficiency is high and the production automation can be realized; and besides, the shape and size of the micropores can be controlled by adjusting the laser energy parameter according to production requirements, and the microneedle templates of different structure parameters can be designed.

Description

technical field [0001] The invention belongs to the technical field of drug delivery equipment, and in particular relates to a microneedle template and a preparation method thereof. Background technique [0002] Transdermal drug delivery is a new drug delivery method that eliminates the pain caused by injection. However, transdermal drug delivery is hindered by the stratum corneum and epidermis of the skin, making it difficult to achieve efficient and precise drug delivery. Microneedle transdermal drug delivery solves this problem. The advantage of microneedles for transdermal drug delivery is that on the one hand, it can penetrate the stratum corneum and epidermis of the skin without causing pain, and improve the efficiency of drug delivery; Advantage. There are many methods for making microneedles, including chemical etching, photolithography, laser cutting, mold (or template) casting, etc. Among them, the microneedle mold (or template) plays an important role in the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18A61M37/00B23K26/382
CPCA61M37/0015A61M2037/0046A61M2037/0053
Inventor 郭新东王淇磊
Owner BEIJING UNIV OF CHEM TECH
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