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Method for preparation of polyvinyl alcohol embolism microball by synchronous solidification

A technology for embolizing microspheres and polyvinyl alcohol with polyvinyl alcohol, which is used in medical science, surgery, etc., can solve the problems of poor control of product sphericity, difficulty in particle size uniformity of microspheres, etc., and achieve controllable particle size. Preparation, avoid microsphere morphology deformation, avoid cumbersome effects

Active Publication Date: 2015-08-26
ENERGY RES INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These preparation methods are all controlled on a large scale, and the size of the microspheres is wide, so it is difficult to achieve the uniformity of the particle size of the microspheres
The latest progress is also reported to use microfluidic micro-droplet technology to prepare microspheres. After the droplets are collected, they need to be placed in a coagulation bath for curing, and the sphericity of the product is not easy to control.

Method used

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  • Method for preparation of polyvinyl alcohol embolism microball by synchronous solidification
  • Method for preparation of polyvinyl alcohol embolism microball by synchronous solidification
  • Method for preparation of polyvinyl alcohol embolism microball by synchronous solidification

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, the preparation of polyvinyl alcohol aqueous solution

[0047] Weigh 10 grams of polyvinyl alcohol particles (average molecular weight 22,000, hydrolysis 99.2%), add 90 grams of distilled water, stir at 75-80°C for 4 hours, and then dissolve into a transparent liquid to obtain a 10% by weight aqueous solution of polyvinyl alcohol .

[0048] As mentioned above, in the same operation, weigh 5 grams of polyvinyl alcohol particles and add 95 grams of distilled water, stir at 75-80° C. for 3.5 hours, and then uniformly dissolve into a transparent liquid to obtain a 5% by weight aqueous solution of polyvinyl alcohol.

Embodiment 2

[0049] Embodiment 2, co-flow micro-scale channel, such as figure 2 As shown, the emission microchannel 3 and the continuous phase fluid microchannel 5 are coaxially connected. The discrete phase fluid flows out through the emission microchannel and is in the same flow direction as the continuous phase fluid. Channel junctions are formed near and collected by droplet collection microchannels 4 .

Embodiment 3

[0050] Embodiment 3, preparation of polyvinyl alcohol microspheres:

[0051] Choose (d) the micro-scale channel of the co-flow channel structure, such as figure 2 As shown, the outlet diameter of the discrete phase fluid channel in the microscale channel is 50 microns, and the diameter of the continuous phase fluid channel is 1000 microns.

[0052] The concentration of the polyvinyl alcohol aqueous solution is 5% by weight, and the aqueous solution of the crosslinking agent is a glutaraldehyde aqueous solution of 50% by weight. The polyvinyl alcohol aqueous solution and the glutaraldehyde The aqueous solution is premixed, and the catalyst aqueous solution is 1 mol / L hydrochloric acid aqueous solution. The premixed solution of polyvinyl alcohol and crosslinking agent and the aqueous catalyst solution were pumped into the discrete phase fluid channel at a constant flow rate of 2mL / h and 0.2mL / h, while liquid paraffin was pumped into the continuous phase at a constant flow rate...

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Abstract

The invention relates to a method for preparation of a polyvinyl alcohol embolism microball by synchronous solidification, the method is based on hydrodynamic principle, in a micro-scale channel, a polyvinyl alcohol aqueous solution, crosslinking agent aqueous solution and catalyst aqueous solution mixed fluid is used as a discrete phase fluid, an organic solvent which is not mutually soluble with water is used as a continuous phase fluid, the discrete phase fluid is divided into a nano-liter scale discrete phase and droplets smaller than nano-liter scale at the two fluid intersection position by shear force and / or extrusion force of the continuous phase fluid and fluid interfacial tension interaction, the droplets are solidified into solid particles by synchronous crosslinking, and the solid particles are washed and dried into the polyvinyl alcohol embolism microball. The polyvinyl alcohol embolism microball prepared by the method is uniform in particle size, size-controllable, and good in degree of sphericity.

Description

technical field [0001] The invention relates to a preparation process of an embolic agent, in particular to a preparation method of polyvinyl alcohol embolic microspheres. Background technique [0002] Transcatheter vascular embolization (TAE) is to inject some embolic agents into the target supply blood vessels of the lesion in a controlled manner to occlude it and block the blood supply, so as to treat tumors and vascular lesions, eliminate the function of diseased organs and stop bleeding. TAE has the characteristics of minimally invasive, accurate positioning, low incidence of complications, good curative effect, and strong repeatability. Especially for tumor treatment, TAE can improve the curative effect and reduce the suffering of patients, and its application and promotion have important social and economic benefits. [0003] The performance and application of embolic agents are the key and core to the success of TAE surgery. Embolic microspheres are currently the m...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/14
Inventor 王立秋李艳王建梅许敏胡素琴孔湉湉
Owner ENERGY RES INST OF SHANDONG ACAD OF SCI
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