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Nutritional composition for improving heart failure

A nutritional composition, a technology for heart failure, applied in the directions of active ingredients of hydroxy compounds, active ingredients of heterocyclic compounds, food science, etc., can solve problems such as obstacles, affecting the prognosis of patients with heart failure, and easy fatigue of patients with heart failure, physical activity function, etc. To achieve the effect of reducing hospitalization rate and increasing skeletal muscle mass

Inactive Publication Date: 2015-09-02
CHANG GUNG MEDICAL FOUND CHANG GUNG MEMORIAL HOSPITAL AT KEELUNG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, these metabolic abnormalities have been shown to affect other organs, including skeletal muscle, leading to fatigue and impairment of physical activity in patients with heart failure
Furthermore, complications of metabolic diseases such as anemia, diabetes, renal dysfunction and cardiac cachexia can greatly affect the prognosis of patients with heart failure

Method used

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  • Nutritional composition for improving heart failure
  • Nutritional composition for improving heart failure
  • Nutritional composition for improving heart failure

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Example 1 Nutritional Assessment Based on Metabolomics-based

[0032] In the present invention, taking advantage of high-throughput and the potential advantages of developing multiple biomarkers, metabolomics is a detection method different from traditional factors, and can distinguish metabolic signatures from pre-heart failure to severe heart failure patients. ) of a platform. After an in-depth understanding of heart failure metabolic disorders (metabolic perturbation), together with in-depth research on nutritional genomics, individualized treatment strategies will be developed.

[0033]According to the ACC / AHA classification system, it is classified as grade C of heart failure. Grade C refers to patients hospitalized due to acute or decompensated chronic heart failure, aged 20 to 85 years, including systolic and diastolic heart exhausted patients. Meanwhile, the normal control group was aged from 20 to 85 years, and had no significant systemic diseases, such as hy...

Embodiment 2

[0043] Example 2 Design of Metabolomics-Based Nutritional Compositions

[0044] In the present invention, based on the discovery of metabolomics, a nutritional composition based on metabolomics is provided to improve heart failure-related abnormalities, nutritional status, functional status and health-related quality of life and reduce heart failure-related Incidence of readmission. The present invention is relevant from basic research to clinical trials, and will benefit patient care and economic benefits.

[0045] Listed below are several different courses of nutritional support for patients with heart failure:

[0046] Nutritional composition: high doses of leucine and histidine, wherein the ratio of histidine to leucine is 1:5 to 1:11, and the dose of leucine is between Between 4.0g and 12.0g. In addition, the following are nutritional supplements of the present invention, and the nutritional composition and nutritional supplements of the present invention are selected ...

Embodiment 3

[0055] Example 3 High doses of leucine and histidine improve clinical parameters, activity function and reduce rehospitalization rate related to heart failure

[0056] In the present invention, to demonstrate that providing high doses of leucine and histidine increases skeletal muscle mass, hemoglobin and 6-minute walking distance, and reduces heart failure-related The incidence of events.

[0057] The present invention is clinically tested with 212 heart failure (HF) patients, and the symptoms of these patients include: (i) having typical signs and symptoms of heart failure, and NYHA functional classification as II to IV grades (by Battler et al. classification≧1 grade), which are hospitalized patients with acute cardiogenic pulmonary congestion based on a chest x-ray diagnosis after exclusion of non-cardiogenic factors; (ii) documented by echocardiograms with <40% left ventricular ejection fraction (left ventricular ejection fraction, LVEF); and (iii) aged between 20 and 85...

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Abstract

The present invention provides a nutritional composition for improving a patient with heart failure; the nutritional composition is consisting of therapeutically effective high amounts of leucine and histidine. The present invention also provides the nutritional supplement comprising the nutritional composition, which may be a beverage product, a dietary supplement or food. The present invention further provides a method of using the nutritional supplement for treating patients with heart failure.

Description

technical field [0001] The invention provides a nutritional composition for patients with cardiovascular diseases, especially a nutritional composition for patients with acute or chronic heart failure. Background technique [0002] Heart failure is a complex clinical syndrome representing the end stage of various cardiac diseases, which may cause a worse prognosis than many cancers. The estimated cost of heart failure is currently 1 to 2% of total healthcare expenditure in developed economies and is expected to continue to increase; however, short- and long-term rates of rehospitalization or mortality associated with heart failure patients remain high , and the current treatment focuses on drug therapy or devices (such as implantable defibrillators and cardiac resynchronization therapy). However, these approaches do not "cure" the patient's condition, not truly alleviate the disease state of heart failure disease. [0003] Heart failure is considered to be a disease with a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/305A23L1/09A23L1/304A23L33/00
CPCA61K31/51A61K31/07A61K31/525A61K31/205A61K33/04A61K31/375A61K31/519A61K33/06A61K31/716A61K31/714A61K31/593A61K31/592A61K31/675A61K31/05A61K31/198A61K31/455A61K31/355A61K33/34A61K31/122A61K31/4172A61K33/30A61K31/132A61K31/19A61K31/4415A61K31/59A61K2300/00
Inventor 王兆弘萧明熙郑美玲
Owner CHANG GUNG MEDICAL FOUND CHANG GUNG MEMORIAL HOSPITAL AT KEELUNG
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