Cefquinome-sulfate breast injection agent for dry period of dairy cows and preparation method thereof

A technology of cefquinome sulfate and breast infusion agent, applied in the field of cefquinome sulfate breast infusion agent and preparation thereof, can solve the problems of long stay time of antibiotics, reduced incidence of mastitis, and reduced scope of influence, and achieves drug delivery. Convenient and fast, easy to scale up production, low local tissue irritation effect

Active Publication Date: 2015-09-02
FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 2) Antibiotics stay in the breast for a long time;
[0008] 4) Reduce the impact range of new infe

Method used

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  • Cefquinome-sulfate breast injection agent for dry period of dairy cows and preparation method thereof
  • Cefquinome-sulfate breast injection agent for dry period of dairy cows and preparation method thereof
  • Cefquinome-sulfate breast injection agent for dry period of dairy cows and preparation method thereof

Examples

Experimental program
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preparation example Construction

[0036] Cefquinome sulfate breast injection (dry milk stage) provided by the invention is a kind of uniformly distributed preparation, and concrete preparation method comprises the following steps:

[0037] A. Let the vegetable oil (such as neutral soybean oil) cool after filtration and heat sterilization;

[0038] B. Take an appropriate amount of pretreated vegetable oil and add 0.03-0.3g of glyceryl monostearate;

[0039] C. Heat at 60-80°C for 15-30 minutes, wait for the glyceryl stearate to melt, stir evenly, cool to about 40°C, add 0.03-0.3g suspending agent (such as Span 80), 0.05-0.3 g (in terms of cefquinome) of cefquinome sulfate (5-10 μm in particle size), add vegetable oil to a total amount of 3.0ml;

[0040] D. grind evenly, make cefquinome sulfate breast injection;

[0041] F. Put the medicine into the injection tube, seal it, sterilize it, inspect it with light, and pack it.

[0042] In the following examples, the detection method of the sedimentation particle ...

Embodiment 1

[0045] Embodiment 1, the prescription screening of cefquinome sulfate breast injection (dry period)

[0046] 1. Screening of glyceryl monostearate content in the formula (note: glyceryl monostearate in the table is referred to as glyceride)

[0047] Table 1

[0048]

[0049] The preparation method is as follows:

[0050] 1) Cefquinoxime sulfate aseptic powder is obtained through ultrafine pulverization to obtain cefquinoxime sulfate aseptic micropowder (particle diameter 5-10 μm);

[0051] 2) After the soybean oil is filtered and heat sterilized (sterilized at 150° C. for 3 hours), it is placed at room temperature for use;

[0052] 3) Take an appropriate amount of pretreated soybean oil, add glyceryl stearate and suspending agent Span 80; heat and stir (heating at 80°C for 15 minutes), after the glyceryl stearate melts, add cefquinone sulfate Oxime;

[0053] 5) Grind evenly in a sterile colloid mill to prepare cefquinome sulfate breast injection.

[0054] As can be see...

Embodiment 2

[0060] Embodiment 2, preparation cefquinome sulfate breast injection (dry period)

[0061]

[0062] The preparation method is as follows:

[0063] 1) the aseptic powder of cefquinoxime sulfate is ultrafinely pulverized to obtain the aseptic micropowder of cefquinoxime sulfate with a particle size of 5-10 μm;

[0064] 2) After the soybean oil is filtered and heat sterilized (sterilized at 150° C. for 3 hours), it is placed at room temperature for use;

[0065] 3) Take an appropriate amount of pretreated soybean oil (40%-60% of the total amount of soybean oil), add glyceryl monostearate; heat and stir (heating at 80°C for 15 minutes), wait for glyceryl monostearate Melt the ester, stir evenly, cool to 40°C, add Span 80, cefquinome sulfate, and add soybean oil to the full amount;

[0066] 4) Grind evenly in a sterile colloid mill to prepare cefquinome sulfate breast injection.

[0067] The properties of the obtained cefquinome sulfate breast injection (dry milk stage) are off...

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Abstract

The invention discloses a cefquinome-sulfate breast injection agent for the dry period of dairy cows and a preparation method thereof. The cefquinome-sulfate breast injection agent is prepared from the following raw auxiliary materials by weight: 0.05 to 0.3g of cefquinome sulfate (calculated by cefquinome), 0.03 to 0.3g of glyceryl monostearate, 0.03 to 0.3g of suspending agent and vegetable oil added to 3.0ml. The preparation process comprises the following steps : taking proper amount of vegetable oil pretreated, adding glyceryl monostearate, heating for melting, then adding the suspending agent and the cefquinome sulfate, then adding the vegetable oil to the total amount, grinding to be uniform and obtaining the cefquinome-sulfate breast injection agent. The cefquinome-sulfate breast injection agent disclosed by the invention has the following advantages that the drug release is slow, the bioavailability is high and the stimulation to local tissues is small; single medication is adopted for each breast area for each cow, so that cross infection is avoided; by breast injection, the use is convenient, the animal stress response caused by injection administration is avoided, and convenience is provided for clinical medication; and the curative effect is obvious and the promotion value is extremely high.

Description

technical field [0001] The invention relates to a cefquinome sulfate breast injection (dry milk period) and a preparation method thereof. Background technique [0002] Cow mastitis is an inflammatory change in mammary glands that is stimulated by physical, chemical, and microbiological factors. It is one of the most common and harmful diseases in dairy farming. In clinical practice, it is seen that the sick cows are depressed, their body temperature rises, and their appetite is lost; their lactation is reduced, their milk is thin, they feel hot and swollen when touched, and their milk contains flocs or milk clots, etc., resulting in a decrease in milk production and milk quality. , has seriously affected the healthy development of the dairy industry. This disease not only causes great economic losses to the breeding industry, but also seriously endangers human health. Therefore, the prevention and treatment of dairy cow mastitis is particularly important. [0003] The dry ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61K47/46A61P15/14
Inventor 李秀波刘义明徐飞闫星刘茂林张道康黄慧丽
Owner FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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