Anti-tumor application of raspberry polysaccharides

A raspberry polysaccharide and anti-tumor drug technology, applied in the field of medicine, can solve the problem of no research on raspberry polysaccharide, and achieve significant social value and market value

Active Publication Date: 2015-09-02
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Anti-tumor application of raspberry polysaccharides
  • Anti-tumor application of raspberry polysaccharides
  • Anti-tumor application of raspberry polysaccharides

Examples

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Effect test

Embodiment 1

[0035] Inhibitory effect of raspberry polysaccharide on tumor growth in melanoma B16F10 mice xenografts

[0036] Take melanoma cells B16F10 in logarithmic growth phase and prepare them into 5×10 cells under sterile conditions 7 0.1 ml of cell suspension / ml was subcutaneously inoculated into the right armpit of C57BL / 6 mice. After 5 days, the diameter of the mouse transplanted tumor was measured with a vernier caliper, and the tumor grew to 60-90mm. 3 After the animals were randomized. Using the method of measuring tumor diameter, the anti-tumor effect of the tested drugs was dynamically observed. The tumor diameter was measured once every 2 days, and the mice were also weighed for each measurement. Grouping and administration methods are as follows: the negative control group was injected with the same amount of normal saline, once a day. The positive control group (docetaxel) was administered subcutaneously, 10 mg / kg, once every three days. The low, middle and high dose ...

Embodiment 2

[0042] Raspberry polysaccharide inhibits the growth of human nasopharyngeal carcinoma CNE xenograft tumor in nude mice

[0043] Take the tumor cells in logarithmic growth phase and prepare them into 5 × 10 under sterile conditions. 7 0.1 ml of cell suspension / ml was subcutaneously inoculated into the right armpit of nude mice. Use a vernier caliper to measure the diameter of the transplanted tumor in nude mice, and when the tumor grows to 100-200mm 3 After the animals were randomized. The anti-tumor effect of raspberry polysaccharide was dynamically observed using the method of measuring tumor diameter. The tumor diameter was measured once every 2 days, and the mice were also weighed for each measurement.

[0044] The administration methods were as follows: the negative control group was injected with the same amount of normal saline, once a day; the cisplatin group was 10 mg / kg, subcutaneously injected, once a week; the raspberry polysaccharide low, middle and high dose gr...

Embodiment 3

[0050] Inhibitory test of raspberry polysaccharide on human glioma U87 xenograft tumor growth in nude mice

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Abstract

The invention provides use of raspberry polysaccharides in preparing anti-tumor medicines, health-care products or foods. A tumor-bearing mouse model is used for evaluating the in-vivo anti-tumor effect of the raspberry polysaccharides; at least, the excellent inhibition effect of the raspberry polysaccharides on tumors derived from skin, head and neck, brain, thyroid, pancreas, gullet, colon or rectum, ovary and prostate of human is discovered; besides, the effect of the raspberry polysaccharides is close to the effects of chemotherapy medicines, but the toxic and side effects of the raspberry polysaccharides are lower; as a result, a new option is provided for treating or preventing tumors.

Description

technical field [0001] The invention belongs to the field of medical science and technology, and particularly relates to the application of raspberry polysaccharide in anti-tumor. Background technique [0002] Malignant tumor is still a major disease that seriously threatens human life. Recent statistics show that there are about 20 million newly discovered cancer patients in my country every year, of which 1.5 million die from cancer. Cancer deaths account for 1 / 5 of all deaths. [0003] Raspberries (Rubus idaeus L.), also known as raspberries, raspberries, raspberries, etc., belong to the genus Rubus of the family Rosaceae. Raspberry is mainly distributed in the temperate and frigid zones of the northern hemisphere, and its fruit is a succulent and small aggregated fruit with a sweet and slightly sour taste. Raspberry contains a variety of active ingredients such as polysaccharides, organic acids, flavonoids, anthocyanins, polyphenols, vitamins, mineral elements, volati...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P35/00A61P35/04A23L1/09
Inventor 索有瑞杨永晶叶英杨芳
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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