Fluffy type skin collagen hemostatic material and preparation method thereof

Abstract

The invention discloses a preparation method of a fluffy type skin collagen hemostatic material. The preparation method is characterized by comprising the following steps: by taking medical purified pig dermis as a raw material, performing repeated alkaline swelling and acid swelling to ensure that the pigskin collagen fibers are moderately separated and loosened on the premise of keeping three-dimensional structures of pigskin collagen fibers unchangeable, and then performing processes such as carbodiimide modification, freeze drying, rewetting, mechanical fluffing and sterilization to finally prepare a cottony fluffy type skin collagen hemostatic material. According to the material disclosed by the invention, a three-dimensional reticular structure of natural pigskin collagen can be completely preserved; and compared with ordinary collagen materials, fluffy type skin collagen prepared by using the method disclosed by the invention has more excellent structure stability, mechanical performance and biodegradability, has good biological performance such as biocompatibility and low immunogenicity, also has the functions of promoting the healing and repair of wound surfaces, and can be applied to rapid and effective hemostasis in a wound repair process.

Description

technical field [0001] The invention relates to the preparation of a fluffy skin collagen hemostatic material with excellent biological properties such as good biocompatibility, biodegradability and low immunogenicity, and belongs to the field of biomedical materials. Background technique [0002] In most surgical and traumatic operations, there will be massive bleeding from the wound surface, which puts patients in great danger of life. Therefore, the preparation of rapid and effective hemostatic materials has always been a research hotspot in the medical field. At present, traditional hemostatic materials such as four-head bands, tourniquets and bandages are still used in the application process of surgery and trauma repair. Such traditional materials have poor hemostatic effect, consume a lot of money, and are not easy to store. In recent years, with the increase of research on new rapidly absorbable hemostatic materials, skin collagen has attracted extensive attention of...

AI Technical Summary

Problems solved by technology

[0007] 1. The existing preparation technology of collagen absorbable hemostatic material needs to extract and prepare collagen from animal skin first, then carry out modification and cross-linking, and finally obtain collagen hemostatic material. The preparation steps are cumbersome, the preparation cycle is long, and the hemostatic effect is average;

[0008] 2. The existing skin collagen extraction and preparation technology is complicated in the extraction process, which will cause damage to the skin collagen structure to a certain extent, make its biomechanical properties worse, and cannot achieve the effect of rapid hemostasis;

[0009] 3. The prepared skin collagen raw materials have low yield, low purity and high cost, sometimes have problems such as cytotoxicity not up to standard, and have been unable to meet the requirements of the current market