A kind of hemostatic anti-adhesion material and preparation method thereof
An anti-adhesion and hemostatic layer technology, which is applied in the field of medical materials, can solve the problems of poor anti-adhesion effect and hemostatic effect, and achieve the effect of increasing the anti-adhesion effect, improving the mechanical strength, and the preparation method is simple and easy
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0039] The present invention also provides a preparation method of a hemostatic and anti-adhesion material, comprising:
[0040] performing an activated cross-linking reaction with the film-forming solution prepared from the first type of absorbable polymer material and an activator to obtain an anti-adhesion gel;
[0041] The anti-adhesion gel is wrapped layer by layer and dried sequentially to obtain an anti-adhesion layer;
[0042] Performing a complexing and crosslinking reaction on the film-forming solution prepared from the second type of absorbable polymer material and a complexing agent to obtain a hemostatic gel;
[0043] The hemostatic gel is formed into a film on the surface of the anti-adhesion layer, and then freeze-dried to obtain the hemostatic and anti-adhesion material.
[0044] In the preparation method provided by the present invention, in the step of preparing the anti-adhesion gel, the first type of absorbable polymer material is prepared into a 2-10% (w / ...
Embodiment 1
[0070] Take the preparation of chitosan-sodium carboxymethyl cellulose / small intestinal mucosa hemostatic and anti-adhesion film as an example.
[0071] 2g sodium carboxymethylcellulose was dissolved in 98g distilled water, stirred and dissolved to obtain 2% (w / w) sodium carboxymethylcellulose solution, then added 0.1% (w / w) 1-ethyl-3-( 3-Dimethylaminopropyl) carbodiimide hydrochloride (EDC), after activating at room temperature for 10 hours, forms a gel, which is placed in ultrapure water and washed repeatedly for 10 times before being homogeneous;
[0072]The small intestinal mucosa was frozen at -30°C for 16 hours and then thawed at room temperature. Repeated freezing and thawing 3 times, after disinfection, placed in 1M NaCl and 0.5M HCl solution for 10 hours to obtain decellularized small intestine Mucosal sublayer material;
[0073] Place the prepared small intestinal mucosal matrix sublayer material in the sodium carboxymethylcellulose solution for 2 hours, take it out...
Embodiment 2
[0078] Take the preparation of hydroxyethyl cellulose-polylactic acid / peritoneal hemostatic anti-adhesion film as an example.
[0079] After drying 5g of polylactic acid powder at 70°C, dissolve it in 95g of dichloromethane, stir vigorously to obtain a 5% (w / w) polylactic acid solution, and then add 0.8% (w / w) dimethylaminopropyl Ethylcarbodiimide (ETC), after being activated at room temperature for 5 hours to form a gel, was placed in ultrapure water and washed repeatedly for 5 times before being homogeneous;
[0080] The pig peritoneum was frozen at -80°C for 24 hours and then thawed at room temperature. Repeated freezing and thawing twice, after disinfection, placed in 0.5M NaCl and 0.1M NaOH solution and repeatedly shaken for 6 hours to obtain pig peritoneum Substratum material;
[0081] The prepared porcine peritoneal sublayer material was placed in the polylactic acid solution for 1 hour, then taken out, and left at room temperature for 1 hour, and this process was repe...
PUM
| Property | Measurement | Unit |
|---|---|---|
| pore size | aaaaa | aaaaa |
| pore size | aaaaa | aaaaa |
| thickness | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More