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Polyacrylonitrile hemodialysis membrane and preparation method thereof

A technology of polyacrylonitrile blood and polyacrylonitrile, which is applied in semi-permeable membrane separation, chemical instruments and methods, dialysis, etc., can solve the problems of poor biocompatibility, prone to coagulation and allergies, and achieve high porosity. , excellent biocompatibility, improving hydrophilicity

Inactive Publication Date: 2015-09-09
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Moreover, the biocompatibility of the polyacrylonitrile hollow fiber membrane itself is poor, and in hemodialysis, coagulation and allergies are prone to occur. , to achieve a better application effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A polyacrylonitrile hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 1.6 μm, the pore diameter is 2.1 μm, and the wall thickness is 70 μm;

[0022] The dialysis membrane is prepared from the following components in mass parts: 30 parts of polyacrylonitrile, 10 parts of polyacrylate, 10 parts of polyphosphazene, 5 parts of polyglycolic acid, 5 parts of polylactic acid, 20 parts of dimethylacetamide parts and 12 parts of acetone.

[0023] A preparation method of polyacrylonitrile hemodialysis membrane, the preparation steps are as follows:

[0024] (1) Preparation of spinning solution: Add polyacrylate, polyphosphazene, polyglycolic acid, polylactic acid and acetone to dimethylacetamide, heat and dissolve in a water bath at 37°C, and when the solution is transparent, ultrasonically dissolve polyacrylonitrile Dispersed in the solution to obtain a spinning solution;

[0025] (2) Electrospinning: electrospinning t...

Embodiment 2

[0029] A polyacrylonitrile hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 1.6 μm, the pore diameter is 2.1 μm, and the wall thickness is 70 μm;

[0030] The dialysis membrane is prepared from the following components in mass parts: 50 parts of polyacrylonitrile, 18 parts of polyacrylate, 16 parts of polyphosphazene, 10 parts of polyglycolic acid, 10 parts of polylactic acid, 35 parts of dimethylacetamide parts and 25 parts of acetone.

[0031] A preparation method of polyacrylonitrile hemodialysis membrane, the preparation steps are as follows:

[0032] (1) Preparation of spinning solution: Add polyacrylate, polyphosphazene, polyglycolic acid, polylactic acid and acetone to dimethylacetamide, heat and dissolve in a water bath at 37°C, and when the solution is transparent, ultrasonically dissolve polyacrylonitrile Dispersed in the solution to obtain a spinning solution;

[0033] (2) Electrospinning: electrospinning...

Embodiment 3

[0037] A polyacrylonitrile hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 1.6 μm, the pore diameter is 2.1 μm, and the wall thickness is 70 μm;

[0038] The dialysis membrane is prepared from the following components in mass parts: 35 parts of polyacrylonitrile, 12 parts of polyacrylate, 12 parts of polyphosphazene, 6 parts of polyglycolic acid, 6 parts of polylactic acid, 26 parts of dimethylacetamide parts and 16 parts of acetone.

[0039] A preparation method of polyacrylonitrile hemodialysis membrane, the preparation steps are as follows:

[0040] (1) Preparation of spinning solution: Add polyacrylate, polyphosphazene, polyglycolic acid, polylactic acid and acetone to dimethylacetamide, heat and dissolve in a water bath at 37°C, and when the solution is transparent, ultrasonically dissolve polyacrylonitrile Dispersed in the solution to obtain a spinning solution;

[0041] (2) Electrospinning: electrospinning t...

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PUM

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Abstract

The invention discloses a polyacrylonitrile hemodialysis membrane and a preparation method thereof, which relate to the field of a biological material. The hemodialysis membrane is a hollow fiber membrane, and the diameter of a hollow fiber of the hollow fiber membrane is in a range of 0.8-3.5 Mum, the pore diameter of the hollow fiber is in a range of 1.2-4.2 Mum, and the thickness of the hollow fiber is in a range of 60-90 Mum. The hemodialysis membrane is prepared by the following components, by mass: 30-50 parts of polyacrylonitrile, 10-18 parts of polyacrylate, 10-16 parts of polyphosphazene, 5-10 parts of polyglycolic acid, 5-10 parts of polylactic acid, 20-35 parts of dimethylacetamide, and 12-25 parts of acetone. The preparation method of the polyacrylonitrile hemodialysis membrane comprises the following steps: (1) preparation of a spinning solution; and (2) electrostatic spinning. The polyacrylonitrile hemodialysis membrane has excellent biocompatibility, can effectively reduce a blood coagulation phenomenon, has a certain toxin cleaning property, and is a relatively ideal hemodialysis membrane.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a polyacrylonitrile hemodialysis membrane and a preparation method of the hemodialysis membrane. Background technique [0002] Hemodialysis membrane uses the principle of semi-permeable membrane, with the help of the solute gradient, osmotic gradient and water pressure gradient on both sides of the membrane, to remove toxins and retain excess water in the body, and at the same time replenish the substances needed in the body, and maintain electrolytes and purpose of acid-base balance. [0003] Due to its good heat resistance, chemical and mechanical stability, polyacrylonitrile can effectively remove harmful substances with large molecular weights in the blood during hemodialysis. However, as a hydrophobic material, it needs to be copolymerized with a hydrophilic monomer, and it can be used for hemodialysis only after it has good hydrophilicity. [0004] Moreover, the biocom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/42B01D69/08B01D67/00B01D61/24
Inventor 李苏杨李文遐徐勤霞
Owner SUZHOU BEC BIOLOGICAL TECH
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