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Blood glucose-reducing application of rosa roxburghii tratt fruit polysaccharides

A technology for lowering blood sugar and fruit, which is applied in the field of the preparation of hypoglycemic drugs with polysaccharides from yellow thorn fruits, and can solve the problems of hypoglycemic reduction of polysaccharides from yellow thorn fruits, etc.

Active Publication Date: 2015-09-16
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there is no report on reducing blood sugar by polysaccharides from the fruit of japonica

Method used

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  • Blood glucose-reducing application of rosa roxburghii tratt fruit polysaccharides
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  • Blood glucose-reducing application of rosa roxburghii tratt fruit polysaccharides

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the preparation of the polysaccharide of the fruit of japonica

[0033] 1) Degreasing of the fruit of C. japonica: Take 400g of ripe fruit of C. chinensis (i.e., Berberis straight panicle) and dry it, crush it and sieve it; mix the fruit of C. japonica with petroleum ether, extract it by ultrasonic after mixing, and centrifuge to remove the extract and residue Filter, evaporate the petroleum ether to obtain the degreased thorn fruit residue;

[0034] 2) Removal of monosaccharides from the fruit of Citrus japonica: mix the residue of the fruit of Citrus japonica with ethanol, the ethanol concentration is 70-85% v / v, reflux extraction, centrifuge to remove the extract, filter the residue and evaporate the ethanol to obtain Residue of removing monosugar thorn fruit;

[0035] 3) Extraction of the crude polysaccharide of C. japonica: mixing the residue of the fruit of C. japonica from which monosaccharides have been removed obtained in step 2) with pure water,...

Embodiment 2

[0038] Embodiment 2: the preparation of the polysaccharide of the fruit of japonica

[0039] 1) Degreasing of the fruit of C. japonica: take 400 g of ripe fruit of C. chinensis (i.e. Berberis straight panicle) and dry it, crush it and sieve it; mix the fruit of C. japonica with petroleum ether, extract by refluxing, centrifuge to remove the extract, filter the residue, Evaporate the sherwood oil to obtain the degreasing fruit residue;

[0040] 2) Removal of simple sugars from the fruit of Citrus japonica: mix the residue of the fruit of Citrus japonica with ethanol, the ethanol concentration is 70-85% v / v, ultrasonically extract, centrifuge to remove the extract, filter the residue and evaporate the ethanol to obtain Residue of removing monosugar thorn fruit;

[0041] 3) Extraction of the crude polysaccharide of C. japonica: mixing the residue of the fruit of C. japonica from which monosaccharides have been removed obtained in step 2) with pure water, extracting by warm soaki...

Embodiment 3

[0044] Embodiment 3: the preparation of the polysaccharide of the fruit of japonica

[0045]1) Degreasing of the fruit of C. japonica: take 400 g of mature fruit of C. chinensis (i.e. Berberis straight panicle) and dry it, crush it and sieve it; mix the fruit of C. japonica with petroleum ether, reflow and extract after ultrasonication, and remove the extract by centrifugation. The residue is filtered, and the petroleum ether is evaporated to obtain the residue of the degreased thorn fruit;

[0046] 2) Removal of simple sugars from the fruit of Citrus japonica: mix the residue of the fruit of Citrus japonica with ethanol, the ethanol concentration is 70-85% v / v, ultrasonically extract, centrifuge to remove the extract, filter the residue and evaporate the ethanol to obtain Residue of removing monosugar thorn fruit;

[0047] 3) Extraction of the crude polysaccharide of C. japonica: mixing the residue of the fruit of C. japonica from which monosaccharides have been removed obta...

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Abstract

The invention provides an application of rosa roxburghii tratt fruit polysaccharides in preparation for blood glucose-reducing medicines, heath products or foods. Researches on the application provided by the invention find that the rosa roxburghii tratt fruit polysaccharides have a good blood glucose-reducing function, can increase an insulin amount, and have a regulation effect on the activities of the corresponding ROS metabolism-related enzymes, that is, the activities of superoxide dismutase, catalase, and glutathion peroxidase to a certain extent. Meanwhile, the application provided by the invention further finds that the effect of a rosa roxburghii tratt fruit high-dose group is equal to the effect of glibenclamide, although glibenclamide is a first-line medicine for treating diabetes, glibenclamide finally causes the hypoglycaemia and kidney diseases of patients, and even causes death in case of being greatly taken for a long time; conversely, rosa roxburghii tratt fruits are edible berries, good in safety, and more suitable for being used as foods, health products or medicines for treating and preventing diabetes.

Description

technical field [0001] The invention belongs to the field of health care products, and in particular relates to the use of polysaccharides from the fruit of japonica japonica in the preparation of hypoglycemic drugs. technical background [0002] According to statistics, the number of people with diabetes in my country has reached 92.4 million, ranking first in the world (Yang W, et al. N Engl J Med, 2010, 362(12): 1090-1101). The cost of diabetes treatment in China is as high as 173.4 billion yuan per year, and the direct medical expenditure caused by diabetes has accounted for 13% of China's total medical expenditure (Alcorn T, et al. Lancet, 2012, 379(9833): 2227-2228). It can be seen that diabetes not only seriously endangers the health of the people, but also brings a heavy economic burden to the country. Therefore, it is urgent to prevent and treat diabetes. [0003] Yellow thorn, Berberis dasystachya Maxim., a plant of Berberidaceae, is a traditional wild berry that...

Claims

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Application Information

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IPC IPC(8): A61K36/29A61K31/715A61P3/10A23L1/29A61K131/00
Inventor 索有瑞韩丽娟杨永晶杨芳
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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