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Composition capable of contracepting offspring and preventing infection of venereal disease and acquired immune deficiency syndrome

A composition, AIDS technology, applied in the direction of sexual diseases, drug combinations, antiviral agents, etc., can solve the problems of no sterilization, antiviral, HIV inhibition activity, no contraceptive, sterilization, antiviral AIDS preparations etc.

Inactive Publication Date: 2015-09-23
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, this ingredient does not have bactericidal, antiviral, and HIV-inhibiting activities, and it cannot be made into a compound preparation with commonly used disinfectants in clinical practice. formulations available
However, there is no report of gossypol as an effective active ingredient for anti-fertility and prevention of virus transmission to prepare vaginal ointment

Method used

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  • Composition capable of contracepting offspring and preventing infection of venereal disease and acquired immune deficiency syndrome
  • Composition capable of contracepting offspring and preventing infection of venereal disease and acquired immune deficiency syndrome
  • Composition capable of contracepting offspring and preventing infection of venereal disease and acquired immune deficiency syndrome

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve 5g of sodium alginate, 5g of Span 80 and 15g of Tween 80 in 775g of water, then add 200g of glycerin to prepare 1kg of matrix.

[0021] Add 3000 mg of gossypol acetate and 50 g of ascorbyl palmitate to the matrix, and stir while adding, so that they are evenly dispersed in the matrix. Then continue to stir, add 3000 mg of didecyldimethylammonium bromide while stirring, and maintain the pH value at pH=6.0±0.2 with lactic acid at the same time, continue stirring for 30 minutes after the addition is completed, and a gel-like ointment is obtained.

[0022] The gel-like ointment is diluted with base according to the ratio of ointment: base = 10:0, 1:1, 1:9, and prepared into preparations with different drug content concentrations for testing.

Embodiment 2

[0024] Sperm were obtained from healthy volunteers 1 hour before the test, the same amount of semen and the test preparation were mixed thoroughly and the sperm movement was observed under a low power microscope. Several fields of view were observed for each sample, and the forward motion of the sperm was measured using a photo-tracking technique.

[0025] In each concentration of the test preparation, sperm motility completely disappeared, and the same result was also observed with rat epididymal sperm. It shows that gossypol acetate, even at a concentration of 300mg / kg, is enough to completely disappear sperm motility.

Embodiment 3

[0027] Mice (C57BL / 6, female, 22-24 g, 10 in total) were taken and fed with common feed. Apply a 1:9 diluted preparation (the concentration of gossypol acetate is 300mg / kg) to the vagina of each female mouse every night, then put 5 male mice into it, and mix the male mice with the female mice in the morning of the next day. separate. Feed continuously for 30 days, and observe the pregnancy and cub situation. After 30 days, the female mice were killed by neck dissection, and the morphological changes of the vagina and uterus were dissected to observe whether there was pregnancy. The female mice in the blank control group were treated with matrix and treated according to the same feeding method, and the female mice in the positive control group were treated with the same amount of commercially available vaginal contraceptive cream and treated according to the same feeding method. The experimental results are listed in Table 1.

[0028] Table 1 Contraceptive effect of various ...

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Abstract

The invention belongs to the technical field of dispensing of pharmaceutical preparations, and particularly relates to composition capable of contracepting an offspring and preventing infection of a venereal disease and an acquired immune deficiency syndrome. The invention provides a vaginal contraceptive ointment which can prevent the infection of the venereal disease and the acquired immune deficiency syndrome and has a good contraceptive effect. Compared with an existing vaginal contraceptive ointment, the vaginal contraceptive ointment takes gossypol which makes sperms lose the motor ability as an effective contraceptive component, a traditional spermicide, namely, phenylmercuric acetate which has a greater toxic and side effect is not used any more, and the vaginal contraceptive ointment is safer and more effective; meanwhile, the antiviral property and the anti-HIV activity property of the gossypol are utilized, the bactericidal effect of double alkyl quaternary ammonium salt fungicides is assisted, the risk of spreading the venereal disease and the acquired immune deficiency syndrome through body fluids during sexual intercourse is eliminated, the infection of the venereal disease and the acquired immune deficiency syndrome during the sexual intercourse can be effectively prevented, and the composition capable of contracepting the offspring and preventing the infection of the venereal disease and the acquired immune deficiency syndrome has broad application prospect in the field of health.

Description

technical field [0001] The invention belongs to the technical field of formulation of pharmaceutical preparations, in particular to a composition capable of contraception and preventing sexually transmitted diseases and AIDS infection. Background technique [0002] STDs and AIDS are a serious threat to human existence. Although condoms can prevent the spread of sexually transmitted diseases and AIDS, most men do not want to wear condoms because they affect the pleasure of sexual life. Therefore, there is an urgent need to replace condoms, which do not affect the pleasure of sexual life and can effectively prevent Agents for the transmission of STDs and AIDS. [0003] Contraception is an old topic. With the rapid growth of the global population, how to prevent unwanted pregnancy has become a very urgent issue, especially in countries that prohibit abortion. There are many methods of contraception, vaginal contraceptive cream is one of them. [0004] Phenylmercuric acetate...

Claims

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Application Information

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IPC IPC(8): A61K31/375A61K31/14A61K31/11A61P15/18A61P15/00A61P31/18A61P31/12A61P31/22A61P31/04A61P31/10
Inventor 汤鲁宏万青华杨菲菲徐惠芬
Owner JIANGNAN UNIV
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