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Coating composition, coated drug preparation prepared from same and preparation method of coated drug preparation

A technology of pharmaceutical preparations and solid pharmaceutical preparations, which is applied in the direction of drug delivery, pharmaceutical formulations, non-active ingredients of polymer compounds, etc., can solve the problems of affecting the effect of controlled release and unsatisfactory disintegration, and achieves the reduction of dependence and the preparation The method is simple and the effect of reducing the influence of the external environment

Inactive Publication Date: 2015-09-30
THE HONG KONG POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its disintegration effect is not ideal, and the effect of controlled release is affected due to factors such as unstable external environment.

Method used

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  • Coating composition, coated drug preparation prepared from same and preparation method of coated drug preparation
  • Coating composition, coated drug preparation prepared from same and preparation method of coated drug preparation

Examples

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preparation example Construction

[0057] The present invention also provides the preparation method of the aforementioned coated pharmaceutical preparation, comprising the following steps:

[0058] (1) Dissolving zein, pectin and plasticizer in a solvent to form a coating solution;

[0059] (2) Putting the solid pharmaceutical preparation in the coating solution for coating, and evaporating the solvent to obtain the coated pharmaceutical preparation.

[0060] Wherein, the type or composition of the solvent is not limited, as long as it can dissolve zein and pectin and is easy to volatilize.

[0061] In one embodiment of the preparation method according to the present invention, the solvent in step (1) may be an aqueous organic solvent solution, and the mass ratio of the aqueous organic solvent solution to zein may be 1:3-6.

[0062] In one embodiment of the preparation method according to the present invention, the organic solvent may be one or more of ethanol, propanol, isopropanol, butylene glycol, pentanol, ...

Embodiment 1

[0079] At normal temperature and pressure, weigh 10g of zein and dissolve it in 50ml of 80% (v / v) ethanol solution, stir with a glass rod until most of the zein is dissolved, add 7ml of oleic acid, and stir with a constant temperature magnetic stirrer Stir at a speed of 600rpm / min until the solution is uniform and transparent. Weigh 1.0 g of pectin, add zein solution, and stir with a magnetic stirrer at a speed of 600 rpm / min for 60 min at about 65°C. Under normal temperature and pressure, the solution is cooled to room temperature to prepare a coating solution. The magnetic stirrer stirred the mixed solution at a speed of 600rpm / min, so that the pectin was evenly dispersed in the solution. Dip the vitamin C tablet into the coating solution for about 5 seconds and drain the excess solution. Then, at room temperature, the solution evaporates to obtain a thin film that wraps the tablet. Repeat the film coating once in the same way to obtain a thickness of about 150 microns. ...

Embodiment 2

[0081] At normal temperature and pressure, weigh 10g of zein and dissolve it in 50ml of 80% (v / v) ethanol solution, stir with a glass rod until most of the zein is dissolved, add 7ml of oleic acid, and stir with a constant temperature magnetic stirrer Stir at a speed of 600rpm / min until the solution is uniform and transparent. Weigh 10 g of pectin, add zein solution, and stir for 60 min at a speed of 600 rpm / min with a magnetic stirrer at about 65°C. Under normal temperature and pressure, the solution is cooled to room temperature to prepare a coating solution. The magnetic stirrer stirred the mixed solution at a speed of 600rpm / min, so that the pectin was evenly dispersed in the solution. Dip the vitamin C tablet into the coating solution for about 5 seconds and drain the excess solution. Then, at room temperature, the solution evaporates to obtain a thin film that wraps the tablet. Repeat the film coating once in the same way to obtain a thickness of about 150 microns.

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Abstract

The invention provides a coating composition comprising zein, pectin and a plasticizer. The invention also provides a coated drug preparation and a preparation method thereof. The coating composition provided by the invention contains natural polymer zein and pectin, is good in stability and water resistance, and can effectively realize controlled release of a drug. The coated drug preparation provided by the invention adopts the coating composition for coating film coating, so that the controlled release of the drug at different time and different parts can be realized. The preparation method of the coated drug preparation provided by the invention is simple, is good in film forming property, and has a great potential for industrial application.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a coating composition containing natural macromolecular substances, and a coating pharmaceutical preparation prepared by using the coating composition and a preparation method. Background technique [0002] Controlled drug release is to use natural or polymer compounds as drug carriers to control the release rate of drugs in the human body, so that drugs can be released slowly within a certain time range and speed to achieve the purpose of treating a certain disease. Compared with conventional release, the advantages of controlled release include: (1) It can effectively control the concentration of drugs, avoiding sudden highs and lows and the occurrence of toxic and side effects; (2) The drug utilization rate is higher than conventional release; (3) ) The release location is close to the source of the disease, thus improving the efficacy of the drug and avoiding system...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/42A61K47/36A61K9/36A61K31/375
Inventor 王奕黄家兴邓惠华
Owner THE HONG KONG POLYTECHNIC UNIV
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