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Method for preparing medicine-carrying polylactic acid surgical sutures

A technique of surgical suture and polylactic acid, which is applied in the field of medicinal chemistry, can solve the problems of unfavorable wound recovery, short duration of antibacterial effect of drugs, large initial concentration of drugs, etc., and achieves the effect of good sustained-release function of drugs

Inactive Publication Date: 2015-10-21
TAIYUAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the general drug-loaded surgical sutures have sudden drug release, the initial concentration of the drug is too high, which is not conducive to wound recovery, and the antibacterial effect of the drug lasts for a short time. Therefore, a polylactic acid with drug-loaded sustained-release function was prepared. Surgical sutures are of great significance

Method used

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  • Method for preparing medicine-carrying polylactic acid surgical sutures
  • Method for preparing medicine-carrying polylactic acid surgical sutures
  • Method for preparing medicine-carrying polylactic acid surgical sutures

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Embodiment Construction

[0020] The chemical substance material used is: polylactic acid, gentamicin sulfate, gelatin, polyoxyethylene sorbitan monooleate, methylene chloride, glycerol, acetic acid, deionized water, and its preparation dosage is as follows: in grams , ml is the unit of measurement

[0021] Polylactic acid: HO[OCCH(CH 3 )O] 825 H 0.8g±0.01g

[0022] Gentamicin Sulfate: C 21 h 43 N 5 o 7 ·H 2 SO 4 3mL±0.1mL

[0023] Gelatin: C 102 h 151 N 31 o 39 1.5±0.01g

[0024] Polyoxyethylene sorbitan monooleate: C 24 h 44 o 6 0.3±0.01g

[0025] Dichloromethane: CH 2 Cl 2 20mL±1mL

[0026] Glycerol: C 3 h 8 o 3 2±0.1mL

[0027] Acetic acid: C 2 h 4 o 2 3±0.1mL

[0028] Deionized water: H 2 O 1000mL±10mL

[0029] The preparation method is as follows:

[0030] Selected Chemical Substance Mat...

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Abstract

The invention relates to the field of medical chemistry, in particular to a method for preparing medicine-carrying polylactic acid surgical sutures. The method for preparing the medicine-carrying polylactic acid surgical sutures includes the steps that polylactic acid medicine-carrying microspheres are firstly prepared, then the polylactic acid medicine-carrying microspheres are loaded onto polylactic acid surgical sutures through a padding method, and the antisepsis and anti-inflammation absorbable surgical sutures with the slow-release function are manufactured. The surgical sutures have the excellent medicine slow-release effect, a medicine sudden-release phenomenon is avoided, and the effective medicine concentration can last for 38 days; in addition, the knot strength and the surface friction coefficient of the polylactic acid surgical sutures obtained after medicine carrying processing are hardly influenced, and original mechanical properties of the surgical sutures are not damaged.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a method for preparing drug-loaded polylactic acid surgical sutures. Background technique [0002] Polylactic acid (PLA) is a medical polymer material with good biocompatibility, biodegradability and absorption. It has good compatibility with human tissue, no carcinogenicity and mutation reaction, and can be gradually degraded in the human body. It is non-toxic and non-irritating to the human body, and can be used as sutures for medical operations after FDA certification. Polylactic acid surgical sutures can be completely degraded into water and carbon dioxide in the human body, so that they can be absorbed by the human body, avoiding inflammation and other adverse effects caused by foreign body reactions, and do not require secondary surgery. At the same time, polylactic acid suture has the advantages of high strength, good flexibility, and easy knotting. Compared with other ...

Claims

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Application Information

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IPC IPC(8): A61L17/12
Inventor 刘淑强肖云超吴改红郭红霞张晓芳戴晋明
Owner TAIYUAN UNIV OF TECH
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