Composite absorbable interface screw and preparation method thereof

An interface screw and heterogeneous technology, applied in the field of medical materials, can solve problems such as poor interface compatibility, and achieve the effects of convenient production, no interference with nuclear magnetic effects, and excellent biodegradability

Inactive Publication Date: 2015-10-21
SHAANXI BOYU REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The purpose of the present invention is to overcome the technical problem of poor interfacial compatibility between bone powder and polylactic acid materials

Method used

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  • Composite absorbable interface screw and preparation method thereof
  • Composite absorbable interface screw and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Step 1, preparation of L-polylactic acid / racemic polylactic acid copolymer

[0033] Add 0.144g of L-lactide, 14.256g of racemic lactide, and 14mg of stannous octoate into the polymerization tube, fill with nitrogen and oxygen, and vacuumize for three times to control the vacuum degree of the polymerization tube to be lower than 1Pa. The polymerization tube was placed in a constant temperature reaction box at 130°C, and reacted for 72 hours to obtain the L-polylactic acid / racemic polylactic acid copolymer.

[0034] In the copolymer prepared in this step, the mass ratio of L-polylactic acid to racemic polylactic acid is 1:99. After measurement, the viscosity-average molecular weight of the copolymer is 50,000, and the intrinsic viscosity is 0.5 dL / g.

[0035] Step 2. Surface modification of xenogeneic deantigenated cortical bone meal

[0036] Dissolve 0.2 g of xenogeneic deantigenated cortical bone powder into 10 ml of stearic acid ethanol solution with a concentration ...

Embodiment 2

[0044] Step 1, preparation of L-polylactic acid / racemic polylactic acid copolymer

[0045] Add 10.08g of L-lactide, 4.32g of racemic lactide, and 14mg of stannous octoate into the polymerization tube, fill with nitrogen and oxygen, and vacuumize for three times to control the vacuum degree of the polymerization tube to be lower than 1Pa. The polymerization tube was placed in a constant temperature reaction box at 130°C, and reacted for 72 hours to obtain the L-polylactic acid / racemic polylactic acid copolymer.

[0046] In the copolymer prepared in this step, the mass ratio of L-polylactic acid to racemic polylactic acid is 70:30. After measurement, the viscosity-average molecular weight of the copolymer is 150,000, and the intrinsic viscosity is 2dL / g.

[0047] Step 2. Surface modification of xenogeneic deantigenated cortical bone meal

[0048] Dissolve 0.2 g of xenogeneic deantigenated cortical bone powder into 20 ml of stearic acid ethanol solution with a concentration of ...

Embodiment 3

[0056] Step 1, preparation of L-polylactic acid / racemic polylactic acid copolymer

[0057] Add 14.256g of L-lactide, 0.144g of racemic lactide, and 14mg of stannous octoate into the polymerization tube, fill with nitrogen to catch up with oxygen, and vacuumize for three times to control the vacuum degree of the polymerization tube to be lower than 1Pa. The polymerization tube was placed in a constant temperature reaction box at 130°C, and reacted for 72 hours to obtain the L-polylactic acid / racemic polylactic acid copolymer.

[0058] In the copolymer prepared in this step, the mass ratio of L-polylactic acid to racemic polylactic acid is 99:1. After measurement, the viscosity-average molecular weight of the copolymer is 500,000, and the intrinsic viscosity is 6.5 dL / g.

[0059] Step 2. Surface modification of xenogeneic deantigenated cortical bone meal

[0060] Dissolve 0.2 g of xenogeneic deantigenated cortical bone powder into 10 ml of stearic acid ethanol solution with a ...

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Abstract

The invention discloses a composite absorbable interface screw and a preparation method thereof. The composite absorbable interface screw comprises 70-95 mass% of a polylactic acid polymer and 5-30 mass% of a surface modified xenogeneic antigen-extracted cortical bone meal. A xenogeneic antigen-extracted cortical bone meal surface modification method comprises the steps: making a stearic acid ethanol solution with the concentration of 5-30 w / v% into a xenogeneic antigen-extracted cortical bone meal stearic acid ethanol solution with the concentration of 2-20 w / v%, then drying at the temperature of 30-80 DEG C and carrying out ball milling. The surface modified xenogeneic antigen-extracted cortical bone meal greatly improves interface compatibility with the polylactic acid polymer. The composite absorbable interface screw has relatively good biological activity and mechanical properties, and can be applicable for reconstruction and fixation of anterior and posterior cruciate ligaments.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and relates to a composite material for fixing bone and tendon, in particular to a composite absorbable interface screw for reconstruction and fixation of anterior and posterior cruciate ligaments. The invention also provides a preparation method for the composite absorbable interface screw. Background technique [0002] Anterior and posterior cruciate ligament injuries are one of the most common knee joint injuries. If not treated properly, it will lead to a decrease in the proprioception of the knee joint, thereby affecting the stability of the knee joint. At present, arthroscopic reconstruction of the cruciate ligament is often used in orthopedic surgery for the treatment of anterior and posterior cruciate ligament injuries. Tunnels are dug in the tibia and femur for installation of tendons and ligaments, and then the tops of tendons and ligaments are fixed to the bone tunnel with in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/14
Inventor 杨亚
Owner SHAANXI BOYU REGENERATIVE MEDICINE CO LTD
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