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Preparation method of biodegradable polyether urethane sponge

A polyether-type polyurethane biodegradable technology, applied in drug delivery, pharmaceutical formulation, application, etc., can solve the problems of difficult control of the content of hydrophilic segments and difficult adjustment of soft and hard segments, so that the added amount is easier to control and easy Effects of operation and improvement of mechanical properties

Inactive Publication Date: 2015-10-28
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to solve the problems in the synthesis of degradable and expandable hemostatic materials that the hard and soft segments are difficult to adjust and the content of the hydrophilic segments is difficult to control, the present invention provides a fully synthetic, non-potential animal-derived, easy-to-operate, hard and soft chain Preparation method of degradable hemostatic sponge with easily adjustable segment ratio and hydrophilic segment content

Method used

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  • Preparation method of biodegradable polyether urethane sponge
  • Preparation method of biodegradable polyether urethane sponge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] 1) Synthesis of double-terminated hydroxyl prepolymer

[0064] Put 0.45g (0.005mol) of 1,4-butanediol in a vacuum reaction flask, stir with a magnet, remove water under vacuum (20Pa) at 100°C for 4 hours, cool to room temperature, and balance with nitrogen gas. Add 24 g of D,L-lactide, 24 g of ε-caprolactone, and 90 μL of stannous octoate (0.2% of the mass of the raw material). Vacuumize and equilibrate with dry nitrogen, repeat three times. Vacuumize to 20Pa, seal the vacuum reaction bottle, heat the oil bath to 140°C, and react for 36 hours to obtain a double-terminated hydroxyl prepolymer.

[0065] 2) Preparation of double-terminated isocyanate-based prepolymer

[0066] Balance the double-terminated hydroxyl prepolymer synthesized in step 1) with nitrogen gas, cool down to 80°C, mix well with 24g PEG (molecular weight: 600) (0.04mol) after vacuum dehydration, and then add 60.5g (0.36mol, - NCO is 8 times the total molar amount of -OH) 1,6-hexamethylene diisocyanat...

Embodiment 2

[0072] 1) Synthesis of double-terminated hydroxyl prepolymer

[0073] Put 0.45g (0.005mol) of 1,4-butanediol in a vacuum reaction flask, stir with a magnet, remove water under vacuum (20Pa) at 100°C for 4 hours, cool to room temperature, and balance with nitrogen gas. Add 24 g of D,L-lactide, 24 g of ε-caprolactone, and 90 μL of stannous octoate (0.2% of the mass of the raw material). Vacuumize and equilibrate with dry nitrogen, repeat three times. Vacuum to 20Pa, seal the vacuum reaction bottle, heat the oil bath to 130°C, and react for 24 hours to obtain a double-terminated hydroxyl prepolymer.

[0074] 2) Preparation of double-terminated isocyanate-based prepolymer

[0075] The double-terminated hydroxyl prepolymer synthesized in step 1) was equilibrated with nitrogen gas, cooled to 80°C, mixed evenly with 36g of PEG (molecular weight: 600) (0.06mol) after vacuum dehydration, and then added 87.4g (0.52mol, - NCO is 8 times the total molar amount of -OH) 1,6-hexamethylene...

Embodiment 3

[0081] 1) Synthesis of double-terminated hydroxyl prepolymer

[0082] Put 0.225g (0.0025mol) of 1,4-butanediol in a vacuum reaction flask, stir with a magnet, remove water under vacuum (20Pa) at 100°C for 4 hours, cool to room temperature, and balance with nitrogen gas. Add 24 g of D,L-lactide, 24 g of ε-caprolactone, and 80 μL of stannous octoate (0.15% of the mass of the raw material). Vacuumize and equilibrate with dry nitrogen, repeat three times. Vacuum to 20Pa, seal the vacuum reaction bottle, heat the oil bath to 120°C, and react for 16 hours to obtain a double-terminated hydroxyl prepolymer.

[0083] 2) Preparation of double-terminated isocyanate-based prepolymer

[0084] The double-terminated hydroxyl prepolymer synthesized in step 1) was equilibrated with nitrogen gas, cooled to 80°C, mixed with 24g PEG (molecular weight: 600) (0.04mol) after vacuum dehydration, and then added 46.3g (0.276mol, - NCO is 6.5 times the total molar amount of -OH) 1,6-hexamethylene dii...

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Abstract

The invention discloses a preparation method of biodegradable polyether urethane sponge. The preparation method comprises 1, double hydroxyl-terminated prepolymer synthesis, 2, double isocyanate group-terminated prepolymer synthesis, 3, polyurethane material preparation and 4, porous sponge preparation. The mechanical properties of the biodegradable polyether urethane sponge can be simply adjusted by adjustment of a ratio of a soft section (comprising polyester and polyether chain segments) to a hard section (comprising a carbamate chain segment), and the degradability of the biodegradable polyether urethane sponge can be simply adjusted by control of content of a hydrophilic component (comprising hydrophilic polyether diol). The biodegradable polyether urethane sponge can be used for organs such as ear, nose and other cavities needing compressing hemostasis.

Description

technical field [0001] The invention relates to the technical field of biodegradable materials, in particular to a preparation method of biodegradable polyether polyurethane sponge. Background technique [0002] Ear and nose surgery is a common surgical operation. Due to the small scope of ear and nose surgery, the local blood vessels are abundant, easy to bleed, and the location is deep, so it cannot be sutured to stop bleeding after surgery, and it must rely on packing to stop bleeding. The purpose of packing is to reduce the pain of patients as much as possible while ensuring hemostasis and anti-adhesion. Therefore, the selection of postoperative packing materials has long been the focus of attention. [0003] In the case of surgical hemostasis in cavities such as ears and nose, traditional non-biodegradable packing materials are usually removed within 24-48 hours or even longer postoperatively. Commonly used punching packing materials are non-expanding and non-degradabl...

Claims

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Application Information

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IPC IPC(8): C08G18/66C08G18/48C08G18/42C08G18/38C08G18/12C08J9/28A61L15/42A61L15/44A61L15/46A61L15/26
CPCC08G18/66A61L24/0015A61L24/0036A61L24/046A61L2300/40A61L2300/404A61L2300/41A61L2400/04C08G18/12C08G18/3831C08G18/4018C08G18/4277C08G18/428C08J9/28C08J2375/08C08L75/08
Inventor 侯昭升尹胜男姜丽娟刘常琳李波祝金凤
Owner SHANDONG NORMAL UNIV
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