Soft bag infusion packaging system with high barrier property to gas and manufacturing method thereof

Abstract

The invention discloses a soft bag infusion packaging system with the high barrier property to gas and a manufacturing method thereof. The packaging system comprises a non-PVC co-extruded film inner bag and a barrier protection bag; a drug cavity used for containing injection drug liquor and protecting gas is formed in the non-PVC co-extruded film inner bag, a seal cavity used for containing the non-PVC co-extruded film inner bag is formed in the barrier protection bag, the non-PVC co-extruded film inner bag is contained in the seal cavity, and the seal cavity is a vacuum seal cavity. According to the soft bag infusion packaging system with the high barrier property to gas, the vacuum seal cavity is formed in the barrier protection bag, the non-PVC co-extruded film inner film is contained in the vacuum seal cavity, therefore, the problem of gas permeation can be solved, and meanwhile the defects of bag body deformation or bag broken caused by gas expansion when high-temperature sterilization is performed can be overcome due to the fact that gas is filled in the seal cavity; the quality security of infusion packaging is improved, heat penetration force in the sterilization process is further enhanced, and the sterilization effect is improved.

Description

technical field [0001] The invention relates to the field of medical packaging, in particular to a soft bag transfusion packaging system with high gas barrier performance and a preparation method thereof. Background technique [0002] The packaging of infusion solutions has gone through glass bottles and plastic bottles, and the process from bottle making to filling and sealing is basically completed in the same clean workshop, and clinical use has achieved progress from fully open to semi-open. In order to avoid secondary pollution and realize fully airtight infusion, the infusion with plastic bag packaging that can shrink automatically has been researched and designed. Currently the most widely used are non-PVC co-extruded film bags and polypropylene stand-up bags. [0003] With the development of clinical application of infusion, the varieties of infusion are no longer just simple saline and glucose. A batch of therapeutic and nutritional infusions such as sodium bicarb...

AI Technical Summary

Problems solved by technology

But the glass bottle packaging has the following shortcomings: (1) the quality is fragile and fragile, and the existence of this deficiency brings great inconvenience to the clinical use of the glass bottle packaging; (2) air must be introduced during infusion. There is likely to cause secondary pollution and changes in the properties of the glass bottle during the infusion process; (3) the surface of the soda-lime glass is easily corroded and falls off, etc., along with the volatilization of carbon dioxide in the glass bottle package, the The alkalinity gradually increases, which makes the surface of the soda-lime glass susceptible to corrosion and peeling off, which may seriously endanger the safety of infusion and patients

However, this structure has the following problems in the subsequent sterilization process: (1) If the inner bag is sterilized at high temperature first, and then the outer bag with barrier properties is added

In this case, on the one hand, it is easy to cause the air in the inner bag to leak out during high temperature sterilization; on the other hand, the outer bag is sealed after sterilization, and the inner bag is no longer sterile

Moreover, because carbon dioxide gas or nitrogen is filled between the inner and outer bags, it is difficult to seal the outer bag of this infusion bag, which is easy to cause the bag to break, and it is difficult to ensure product safety.

(2) If the overall high-temperature sterilization of the infusion package is carried out after adding an outer bag with barrier properties, the presence of carbon dioxide gas or nitrogen may prevent heat penetration, resulting in uneven sterilization; and the gas may expand during heating , easy to cause the bag to break or deform

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